Abstract: Provided is a novel light adjustment program that can make a human feel at ease. Provided is the light adjustment program that includes the steps of obtaining basic data having 1/f fluctuation characteristics; generating first smoothed data and second smoothed data by performing moving average processing with different periods on the basic data having 1/f fluctuation characteristics; generating light adjustment data by subjecting the first smoothed data and the second smoothed data to arithmetic processing; and changing luminance of a light-emitting device in time series in accordance with the light adjustment data.

Abstract: A vehicle steering control device includes a control device. The control device is configured to control a steering reaction force to be applied to a steering operation performed by a driver of a driver's vehicle, acquire information on a curved road ahead of the driver's vehicle in a traveling direction, set a guide steering operation amount based on the information on the curved road, predict a time at which the driver starts an actual steering operation for driving the driver's vehicle along the curved road as a steering operation start time, and set, based on a difference between the guide steering operation amount and an actual amount of the steering operation, the steering reaction force at a time earlier by a predetermined period than the steering operation start time.

Abstract: Pressure-responsive particles include pressure-responsive base particles and fatty acid metal salt particles, in which the pressure-responsive base particles contain a styrene-based resin which contains styrene and other vinyl monomers as polymerization components and a (meth)acrylic acid ester-based resin which contains at least two kinds of (meth)acrylic acid esters as polymerization components and in which amass ratio of the (meth)acrylic acid esters to all polymerization components is 90% by mass or higher, the pressure-responsive particles have at least two glass transition temperatures, and a difference between the lowest glass transition temperature and the highest glass transition temperature is 30° C. or higher.

Abstract: An antibody-drug conjugate represented by formula (I): (where Ab is an antibody, X is a group represented by formula (X-1), formula (X-2) or formula (X-3): (where at the left represents the binding site with NH and at the right represents the binding side with D), D is a group represented by formula (D-1) or formula (D-2): (where represents the binding site with X), and n is in the range of about 1 to about 8).

Abstract: The present invention relates a combination drug for treating a renal cancer and a potentiator for therapeutic effects of a tyrosine kinase inhibitor. The combination drug includes a combination of a tyrosine kinase inhibitor, and a dipeptidyl peptidase-4 inhibitor. The potentiator includes a dipeptidyl peptidase-4 inhibitor. The potentiator enhances therapeutic effects of a tyrosine kinase inhibitor on a renal cancer.

Abstract: A shell and plate heat exchanger includes a shell and a plate pack. The shell defines a cavity configured to receive a first fluid and a second fluid. The plate pack is arranged inside the cavity. The plate pack has a plurality of heat exchanger plates. Each of the heat exchanger plates has two sides facing in opposite directions in a thickness direction of the heat exchanger plate. At least one of the sides of at least one of the heat exchanger plates has a surface roughness of between 5 ?m and 100 ?m.

Abstract: Pressure-responsive particles include pressure-responsive base particles and fatty acid metal salt particles, in which the pressure-responsive base particles contain a styrene-based resin which contains styrene and other vinyl monomers as polymerization components and a (meth)acrylic acid ester-based resin which contains at least two kinds of (meth)acrylic acid esters as polymerization components and in which amass ratio of the (meth)acrylic acid esters to all polymerization components is 90% by mass or higher, the pressure-responsive particles have at least two glass transition temperatures, and a difference between the lowest glass transition temperature and the highest glass transition temperature is 30° C. or higher.

Abstract: A charging prediction system includes vehicles, a charging station, and a control device including one or more processors and one or more memories. The one or more processors are configured to execute a process. The process includes accumulating, in a storage device, record data that is actual data on a charged vehicle ratio for a first remaining traveling distance of each of the vehicles traveling along a specific traveling road. The process includes deriving, based on the record data, a predicted value of the charged vehicle ratio for each vehicle in a predetermined group including ones of the vehicles currently traveling along the specific traveling road. The process includes deriving a predicted waiting period that is a predicted value of a waiting period to a start of charging at the charging station based on the predicted values of the charged vehicle ratios.

Abstract: A pressure sensitive adhesive particle includes a pressure sensitive adhesive base particle that contains a styrene resin containing styrene and a vinyl monomer other than styrene as polymerization components, and a (meth)acrylate resin containing at least two (meth)acrylates as polymerization components, in which a mass ratio of the (meth)acrylates relative to a total of polymerization components of the (meth)acrylate resin is 90 mass % or more; and an external additive. The pressure sensitive adhesive particle has a surface having an arithmetic average roughness Ra within a range of 0.005 ?m to 0.100 ?m. The pressure sensitive adhesive particle has at least two glass transition temperatures, and the difference between the lowest glass transition temperature and the highest glass transition temperature among the glass transition temperatures of the pressure sensitive adhesive particle is 30° C. or more.

Abstract: Oxidizing an oligonucleotide precursor having a phosphite ester bond or a phosphonate ester bond with an oxidant, wherein the oxidant is a compound represented by the formula (I) excluding 2,2-dipyridyl disulfide: wherein the symbols are as defined in the specification is useful for producing an oligonucleotide having a phosphate ester bond.

Abstract: A visual field test device includes: first probability density function acquisition unit performs step (1) of obtaining a probability density function f(x1) for a result value x1 obtained in a first visual field test; a stimulation threshold determination unit performs step (2) of setting a stimulation threshold t1 to a value in the range of x1 in the f(x1); a test result acquisition unit performs step (3) of obtaining test results indicating if a result greater than or equal to t1 was obtained in the first visual field test; a second probability density function acquisition unit performs step (4) of obtaining a probability density function f(x2) by removing probability density values that's greater than or equal to t1, or removing values that are less than t1 from f(x1); and a determination unit performs step (5) of determining if a standard deviation ? of the f(x2) is below a predetermined value.

Abstract: A method for producing a composite resin particle dispersion includes: performing polymerization A by polymerizing a styrene compound and a vinyl monomer other than the styrene compound to form a styrene-based resin; performing polymerization B by polymerizing a (meth)acrylic acid ester compound in the presence of the styrene-based resin to form intermediate resin particles containing the styrene-based resin and a (meth)acrylic acid ester-based resin; and performing polymerization C by polymerizing a styrene compound and a vinyl monomer other than the styrene compound in the presence of the intermediate resin particles to form composite resin particles. The mass ratio of the styrene-based resin to the (meth)acrylic acid ester-based resin in the composite resin particles is from 80:20 to 20:80. A difference between the lowest glass transition temperature and the highest glass transition temperature in the composite resin particles is 30° C. or more.

Abstract: The object of the present invention is to provide a therapeutic agent for treating hormone therapy-resistant, treatment-resistant cancers, and a method of the treatment of hormone therapy-resistant, treatment-resistant cancers. The problem can be solved by a pharmaceutical composition including a compound represented by the formula (1) or a salt thereof or a compound represented by the formula (2) or (3) or a salt thereof, as an active ingredient for treating prostate cancer. Furthermore, the pharmaceutical composition of the present invention can effectively treat not only hormone therapy-resistant prostate cancer or breast cancer but also non-hormone therapy-resistant prostate cancer or breast cancer and Castration-resistant prostate cancer or treatment-resistant breast cancer caused by other mechanisms.

Abstract: A vehicle steering assist device in which the steering assist ECU calculates a target steering angle for driving a vehicle along a traveling path, and is vehicle steering assist device that a calculates a target steering guide torque for facilitating the steering angle to become a target steering angle by reducing a return torque for urging the steering wheel to a neutral position in an area where the steering angle is smaller than the target steering angle, wherein when the steering angular velocity is higher than the target steering angular velocity, the steering support ECU calculates a target steering angular velocity control torque acting in a direction opposite to a direction in which the steering angle changes, and controls the control steering torque generating device so as to generate a control steering torque including a sum of the target steering guide torque and the target steering angular velocity control torque.

Abstract: Pressure-responsive particles include pressure-responsive base particles and inorganic oxide particles, in which the pressure-responsive base particles contain a styrene-based resin which contains styrene and other vinyl monomers as polymerization components and a (meth)acrylic acid ester-based resin which contains at least two kinds of (meth)acrylic acid esters as polymerization components and in which amass ratio of the (meth)acrylic acid esters to all polymerization components is 90% by mass or higher, a liberation rate of the inorganic oxide particles is 10% by mass or higher and 40% by mass or lower, the pressure-responsive particles have at least two glass transition temperatures, and a difference between a lowest glass transition temperature and a highest glass transition temperature is 30° C. or higher.

Abstract: A method for producing a composite resin particle dispersion includes: performing polymerization A by polymerizing a styrene compound and a vinyl monomer other than the styrene compound to form a styrene-based resin; performing polymerization B by polymerizing a (meth)acrylic acid ester compound in the presence of the styrene-based resin to form intermediate resin particles containing the styrene-based resin and a (meth)acrylic acid ester-based resin; and performing polymerization C by polymerizing a styrene compound and a vinyl monomer other than the styrene compound in the presence of the intermediate resin particles to form composite resin particles. The mass ratio of the styrene-based resin to the (meth)acrylic acid ester-based resin in the composite resin particles is from 80:20 to 20:80. A difference between the lowest glass transition temperature and the highest glass transition temperature in the composite resin particles is 30° C. or more.

Abstract: The present invention aims to provide an active energy ray-curable ink composition which can constitute a composition having good flowability during printing. The present invention relates to an active energy ray-curable ink composition, containing an allylic polymer, a dispersant, and a pigment, the allylic polymer being produced by polymerizing an allylic compound represented by the following formula (I): wherein R1 and R2 each represent H or CH3; X represents an a-valent group having an unsubstituted saturated or partially unsaturated four- to eight-membered cyclic backbone; and a represents 2 or 3.

Abstract: A vision testing device and related technique, the vision testing device including a touch screen, sequentially displaying visual targets on the touch screen while displaying a fixation target whose position is fixed on the touch screen, during a period from the beginning to the end of the test, and providing a test result based on whether a testee taps the visual target or not.

Abstract: A vehicle control apparatus to be applied to a hybrid vehicle includes a continuously variable transmission, a clutch mechanism, and a travel processor. The continuously variable transmission is coupled to an engine and a first motor via an input passage, and coupled to drive wheels via an output passage. The clutch mechanism is provided on the output passage. When the travel mode is switched from a first mode in which the clutch mechanism is engaged to the second mode in which the clutch mechanism is released, the travel processor releases the clutch mechanism and stops the continuously variable transmission while maintaining a speed ratio of the continuously variable transmission. When the travel mode is switched from the second mode to the first mode, the travel processor synchronizes rotation speeds of input-side and output-side portions of the clutch mechanism by controlling the continuously variable transmission, and engages the clutch mechanism.

Abstract: When it is determined that there is no possibility of a driver performing a predetermined steering operation for moving a host vehicle in a lateral direction without involving a change in a final travel direction, a vehicle control device sets a steering reaction force to be greater than a standard reaction force. When it is determined that there is a possibility thereof, the vehicle control device sets the steering reaction force to be smaller than the standard reaction force, and sets an increase rate of the steering reaction force relative to an increase in the amount of steering operation from a predetermined point in time after it is determined that there is a possibility of the driver performing the predetermined steering operation and before the amount of steering operation in the predetermined steering operation becomes largest to be higher than an increase rate before the predetermined point in time.