Abstract: The object of the present invention is to provide a therapeutic agent for treating hormone therapy-resistant, treatment-resistant cancers, and a method of the treatment of hormone therapy-resistant, treatment-resistant cancers. The problem can be solved by a pharmaceutical composition including a compound represented by the formula (1) or a salt thereof or a compound represented by the formula (2) or (3) or a salt thereof, as an active ingredient for treating prostate cancer. Furthermore, the pharmaceutical composition of the present invention can effectively treat not only hormone therapy-resistant prostate cancer or breast cancer but also non-hormone therapy-resistant prostate cancer or breast cancer and Castration-resistant prostate cancer or treatment-resistant breast cancer caused by other mechanisms.

Abstract: A vehicle steering assist device in which the steering assist ECU calculates a target steering angle for driving a vehicle along a traveling path, and is vehicle steering assist device that a calculates a target steering guide torque for facilitating the steering angle to become a target steering angle by reducing a return torque for urging the steering wheel to a neutral position in an area where the steering angle is smaller than the target steering angle, wherein when the steering angular velocity is higher than the target steering angular velocity, the steering support ECU calculates a target steering angular velocity control torque acting in a direction opposite to a direction in which the steering angle changes, and controls the control steering torque generating device so as to generate a control steering torque including a sum of the target steering guide torque and the target steering angular velocity control torque.

Abstract: Pressure-responsive particles include pressure-responsive base particles and inorganic oxide particles, in which the pressure-responsive base particles contain a styrene-based resin which contains styrene and other vinyl monomers as polymerization components and a (meth)acrylic acid ester-based resin which contains at least two kinds of (meth)acrylic acid esters as polymerization components and in which amass ratio of the (meth)acrylic acid esters to all polymerization components is 90% by mass or higher, a liberation rate of the inorganic oxide particles is 10% by mass or higher and 40% by mass or lower, the pressure-responsive particles have at least two glass transition temperatures, and a difference between a lowest glass transition temperature and a highest glass transition temperature is 30° C. or higher.

Abstract: A method for producing a composite resin particle dispersion includes: performing polymerization A by polymerizing a styrene compound and a vinyl monomer other than the styrene compound to form a styrene-based resin; performing polymerization B by polymerizing a (meth)acrylic acid ester compound in the presence of the styrene-based resin to form intermediate resin particles containing the styrene-based resin and a (meth)acrylic acid ester-based resin; and performing polymerization C by polymerizing a styrene compound and a vinyl monomer other than the styrene compound in the presence of the intermediate resin particles to form composite resin particles. The mass ratio of the styrene-based resin to the (meth)acrylic acid ester-based resin in the composite resin particles is from 80:20 to 20:80. A difference between the lowest glass transition temperature and the highest glass transition temperature in the composite resin particles is 30° C. or more.

Abstract: The present invention aims to provide an active energy ray-curable ink composition which can constitute a composition having good flowability during printing. The present invention relates to an active energy ray-curable ink composition, containing an allylic polymer, a dispersant, and a pigment, the allylic polymer being produced by polymerizing an allylic compound represented by the following formula (I): wherein R1 and R2 each represent H or CH3; X represents an a-valent group having an unsubstituted saturated or partially unsaturated four- to eight-membered cyclic backbone; and a represents 2 or 3.

Abstract: A vision testing device and related technique, the vision testing device including a touch screen, sequentially displaying visual targets on the touch screen while displaying a fixation target whose position is fixed on the touch screen, during a period from the beginning to the end of the test, and providing a test result based on whether a testee taps the visual target or not.

Abstract: A vehicle control apparatus to be applied to a hybrid vehicle includes a continuously variable transmission, a clutch mechanism, and a travel processor. The continuously variable transmission is coupled to an engine and a first motor via an input passage, and coupled to drive wheels via an output passage. The clutch mechanism is provided on the output passage. When the travel mode is switched from a first mode in which the clutch mechanism is engaged to the second mode in which the clutch mechanism is released, the travel processor releases the clutch mechanism and stops the continuously variable transmission while maintaining a speed ratio of the continuously variable transmission. When the travel mode is switched from the second mode to the first mode, the travel processor synchronizes rotation speeds of input-side and output-side portions of the clutch mechanism by controlling the continuously variable transmission, and engages the clutch mechanism.

Abstract: When it is determined that there is no possibility of a driver performing a predetermined steering operation for moving a host vehicle in a lateral direction without involving a change in a final travel direction, a vehicle control device sets a steering reaction force to be greater than a standard reaction force. When it is determined that there is a possibility thereof, the vehicle control device sets the steering reaction force to be smaller than the standard reaction force, and sets an increase rate of the steering reaction force relative to an increase in the amount of steering operation from a predetermined point in time after it is determined that there is a possibility of the driver performing the predetermined steering operation and before the amount of steering operation in the predetermined steering operation becomes largest to be higher than an increase rate before the predetermined point in time.

Abstract: A heat exchanger includes: heat transfer tubes aligned with one another; a header connected to end portions of the heat transfer tubes; and fins joined to the heat transfer tubes. When viewed in a longitudinal direction of the header and when the heat exchanger is used as an evaporator, the header is divided into: a circulation space including a first space in which refrigerant flows in a first direction along the longitudinal direction of the header and a second space in which the refrigerant flows in a second direction opposite to the first direction along the longitudinal direction; and an insertion space into which the heat transfer tubes are inserted. The header includes: a circulation division plate that divides the first space from the second space; and an insertion space forming plate that divides the circulation space from the insertion space.

Abstract: A vehicle control apparatus includes a planetary gear mechanism, first and second wheels, an engine, a motor generator, a wheel drive clutch, and a control system. The planetary gear mechanism includes first, second, and third rotation elements. The first wheel is coupled to the first rotation element via a first path. The second wheel is coupled to the second rotation element via a second path. The engine is coupled to the third rotation element via a third path. The motor generator is provided on the first path. The wheel drive clutch is provided on the first path and between the motor generator and the first wheel. The control system controls the motor generator and the wheel drive clutch. The control system executes a motor stop mode in which the wheel drive clutch is brought into a released state and the motor generator is brought into a rotation stop state.

Abstract: In a vehicle steering assist device that includes an electric power steering device that generates a control torque that modifies a return torque for urging a steering wheel to a neutral position, a steering assist ECU that controls the control torque, and a surrounding information detecting device (camera sensor, radar sensor) that detects at least information in front of a vehicle, the control torque is controlled such that a ratio of a change amount of the modified return torque to a change amount of a steering operation amount at the start of avoidance steering decreases when an obstacle is detected in front of the vehicle by the surrounding information detecting device and the avoidance steering for the vehicle to avoid collision with the obstacle is determined to be required.

Abstract: A driving assistance system performs a driver-initiative normal driving assistance mode as a driving assistance for a vehicle. The system includes a reaction force characteristics change unit configured to change reaction force characteristics of the operation device, if it is determined that the operation amount of the driver is not included in the appropriate operation amount range in the normal driving assistance mode, an explicit risk determination unit configured to determine whether or not an explicit risk is present based on the external environment of the vehicle, and a driving assistance switching unit configured to switch a driving assistance for the vehicle from the normal driving assistance mode to a system-initiative risk avoidance assistance mode, if it is determined by the explicit risk determination unit that the explicit risk is present in the normal driving assistance mode.

Abstract: Appropriately perform solid-liquid separation. A separation device (1) includes a casing (10), a screw shaft (12), a first screw blade (14), and a second screw blade (16). At least one of the first screw blade (14) and the second screw blade (16) has an opening that penetrates from one surface to another surface, designed based on the outflow of separated liquid (C) and solids from the screw blade.

Abstract: A vehicle control system to be mounted in a hybrid electric vehicle includes an engine, a center differential that includes a front-wheel-side output portion and a rear-wheel-side output portion and distributes torque outputted from the engine to a front wheel and a rear wheel, a limited slip differential mechanism that limits a differential between the front-wheel-side output portion and the rear-wheel-side output portion, and a motor disposed in a drive-power transferring system that transfers drive power from the rear-wheel-side output portion to the rear wheel. The vehicle control system includes a processor. When the hybrid electric vehicle is switched from a first traveling mode to a second traveling mode, the processor stops the engine while causing the limited slip differential mechanism to limit the differential between the front-wheel-side output portion and the rear-wheel-side output portion.

Abstract: A display device includes: a base substrate; a thin-film transistor layer provided on the base substrate and having a stack of, in sequence, a lower wire, a flattening film composed of an organic insulating film, an interlayer insulating film composed of an inorganic insulating film, and an upper wire; and a light-emitting element layer, wherein the flattening film has a first contact hole formed to pass through the flattening film and formed for electrically connecting the lower wire and the upper wire together, the interlayer insulating film has a second contact hole formed to pass through the interlayer insulating film and formed for electrically connecting the lower wire and the upper wire together, and at least a part at an edge of the flattening film provided with the first contact hole is exposed from an edge of the interlayer insulating film provided with the second contact hole.

Abstract: A heat exchanger includes: a header that extends in a horizontal direction; and heat transfer tubes that extends in a direction crossing the horizontal direction, that are disposed side by side in a longitudinal direction of the header, and that are connected to the header. The header includes a first space that causes a refrigerant to flow in a first direction along the longitudinal direction of the header, a second space that causes the refrigerant to flow in a second direction along the longitudinal direction of the header and opposite to the first direction, a circulation member extends in the longitudinal direction of the header and separates the first space from the second space, a first communication port, a second communication port, and an inflow port.

Abstract: A driving assistance apparatus predicts an appropriate operation amount which is an operation amount performed by a driver in correspondence with the external environment, and sets the appropriate operation amount range including the appropriate operation amount, an appropriate operation amount range including the appropriate operation amount, and changes the reaction force characteristics of the operation device when it is determined that the operation amount of the driver corresponding to the prediction time point of the appropriate operation amount is not included in the appropriate operation amount range.

Abstract: A control unit that controls a reaction force actuator that applies steering guide torque to a steering wheel: calculates, based on a curvature of a curve of a travel road in front of a vehicle detected by a camera sensor, a target steering angle for causing the vehicle to travel along the curve; calculates a target steering guide torque, based on a deviation between the target steering angle that was calculated a prediction time period earlier and an actual steering angle; adjusts a target steering guide torque such that the target steering guide torque becomes smaller as a probability that a driver performs steering operation to deviate from a lane becomes higher; and controls the reaction force actuator such that the steering guide torque becomes the target steering guide torque.

Abstract: A vehicle steering control device includes a control device. The control device is configured to control a steering reaction force to be applied to a steering operation performed by a driver of a driver's vehicle, acquire information on a curved road ahead of the driver's vehicle in a traveling direction, set a guide steering operation amount based on the information on the curved road, predict a time at which the driver starts an actual steering operation for driving the driver's vehicle along the curved road as a steering operation start time, and set, based on a difference between the guide steering operation amount and an actual amount of the steering operation, the steering reaction force at a time earlier by a predetermined period than the steering operation start time.

Abstract: Provided are a purification method for a polyarylene sulfide (PAS) that can efficiently reduce the amount of a carboxyalkylamino group-containing compound in the PAS by treating the carboxyalkylamino group-containing compound in the PAS under a low pressure without using a strong acid, and a production method for a PAS having a reduced amount of the carboxyalkylamino group-containing compound in the PAS. The purification method for a PAS includes: a step of obtaining a crude PAS-containing mixture by removing a solvent from a crude reaction product containing the PAS obtained by reacting a polyhalo aromatic compound with a sulfidizing agent in an organic polar solvent; a step of bringing the crude PAS mixture into contact with water and an oxygen atom-containing solvent to convert the crude PAS into porous particles; and a step of bringing the obtained porous particles into contact with carbonated water.