Abstract: Methods of culturing cells capable of producing desired proteins to obtain the proteins by use of a medium from which biological components are excluded as much as possible are provided. Specifically, a culture method characterized by culturing while maintaining a specific amino acid in a culture solution at a high concentration, and a cell culture fed-batch medium for use in the method are provided.

Abstract: A vehicle operation detection device includes sensors laid out in a vehicle along an axis in an opening-closing direction of a door of the vehicle. When the user moves a part of a body toward the sensors and a motion of moving the part of the body along the axis is detected, the sensors detect an opening-closing operation for the door. The vehicle operation detection device further includes light-emitting members laid out in the vehicle along the axis in the opening-closing direction and an operation direction indicator configured to drive the light-emitting members in sequence in a first direction in a fully-closed state of the door and drives the light-emitting members in sequence in a second direction in a fully-open state of the door.

Abstract: Methods of culturing cells capable of producing desired proteins to obtain the proteins by use of a medium from which biological components are excluded as much as possible are provided. Specifically, a culture method characterized by culturing while maintaining a specific amino acid in a culture solution at a high concentration, and a cell culture fed-batch medium for use in the method are provided.

Abstract: A control device sets a second electricity control switch in an intermediate state in a process of switching a discharge battery for supplying a drive unit with an electrical current from a first battery to a second battery. Subsequently, when a comparative relationship between an electric potential of a smoothing capacitor and an electric potential of the second battery fulfills an intermediate state termination condition, the control device sets the second electricity control switch in a bidirectional conduction state. The intermediate state is when an electrical current flowing from the second battery to the drive unit is allowed, and an electrical current flowing from the drive unit to the second battery is inhibited. The bidirectional conduction state is when both of the electrical current flowing from the second battery to the drive unit and the electrical current flowing from the drive unit to the second battery are allowed.

Abstract: The present invention aims to provide a more stable and efficient method for producing oligonucleotide, particularly, oligonucleotide having various functional groups linked to the 3?-terminal and the like.

Abstract: A graphite film has a higher degree of thermal diffusion property in one in-plane direction and a method produces the graphite film. The graphite film includes a first axial direction, which is a direction having the highest thermal diffusivity in a film surface, and a second axial direction orthogonal to the first axial direction in the film surface. A value obtained by dividing the thermal diffusivity in the first axial direction by a thermal diffusivity in the second axial direction is not less than 1.020 and not more than 1.300.

Abstract: Provided are a heating furnace and a graphite production method both of which allow a carbonization step and a graphitization step to be consecutively performed. The heating furnace is a heating furnace for producing graphite from a polymeric material, and includes a heating furnace body for subjecting the polymeric material to heat treatment. The heating furnace body includes a closed vessel for containing the polymeric material. A gas outlet pipe is connected to the closed vessel, the gas outlet pipe being for letting, out of the heating furnace body, a pyrolytic gas generated from the polymeric material.

Abstract: A rolled graphite sheet includes a rod-shaped body and a graphite sheet having a length of 1 m or more and a width shorter than the length. The graphite sheet is wound around the rod-shaped body and is rolled in a length direction. When a length direction-end of the graphite sheet is pulled with a force of 1.5 N/cm in a direction parallel to a tangent of a cross-sectional circle of the rolled graphite sheet while fixing the rod-shaped body, the end moves 5 mm or less in the direction parallel to the tangent of the circle.

Abstract: Oligonucleotides may be produced by a process, including (1) condensing a nucleoside, nucleotide or oligonucleotide (b), and a nucleoside, nucleotide or oligonucleotide (a), or a substituted nucleotide or oligonucleotide (?) in a non-polar solvent to give a reaction solution containing a phosphite triester product (c); (3) oxidizing or sulfurizing the phosphite triester product (c) to give a reaction solution containing an oligonucleotide (d) wherein the 5?-hydroxy group is protected; (4) deprotecting the oligonucleotide (d) to give a reaction solution containing an oligonucleotide (e) wherein the 5?-hydroxy group is not protected; and (6) adding a polar solvent to the reaction solution containing the oligonucleotide (e) and purifying the oligonucleotide (e) by solid-liquid separation, wherein said nucleoside, nucleotide or oligonucleotide (a) or said substituted nucleotide or oligonucleotide (?) is a compound represented by formula (a-i): wherein Base, Rp1, R10, m, L, Y, and Z are defined herein.

Abstract: A vehicle operation detection device includes sensors laid out in a vehicle along an axis in an opening-closing direction of a door of the vehicle. When the user moves a part of a body toward the sensors and a motion of moving the part of the body along the axis is detected, the sensors detect an opening-closing operation for the door. The vehicle operation detection device further includes light-emitting members laid out in the vehicle along the axis in the opening-closing direction and an operation direction indicator configured to drive the light-emitting members in sequence in a first direction in a fully-closed state of the door and drives the light-emitting members in sequence in a second direction in a fully-open state of the door.

Abstract: An electrically power assisted bicycle includes an electric motor that generates an assist force assisting human power of a rider, a detachable battery that supplies electric power to the electric motor, a headlight, and an operation panel including a display that displays information, a power button that turns on or off the electrically power assisted bicycle, an illuminance sensor that outputs a signal in accordance with received light, and a controller configured or programmed to control the headlight to be on or off. The power button and the illuminance sensor are located close to each other on or in the operation panel. After a predetermined time period passes after the controller is activated by the power button being pressed by the rider, the controller starts controlling the headlight to be on or off in accordance with the signal output by the illuminance sensor.

Abstract: A graphite film has a higher degree of thermal diffusion property in one in-plane direction and a method produces the graphite film. The graphite film includes a first axial direction, which is a direction having the highest thermal diffusivity in a film surface, and a second axial direction orthogonal to the first axial direction in the film surface. A value obtained by dividing the thermal diffusivity in the first axial direction by a thermal diffusivity in the second axial direction is not less than 1.020 and not more than 1.300.

Abstract: It is possible to obtain a graphite film with its shape controlled, by performing a sag controlling step of controlling temperatures of a polymer film at both widthwise ends and a temperature of the polymer film in a widthwise middle portion within a temperature range from a starting temperature of thermal decomposition of the polymer film to a sag controlling temperature of the polymer film.

Abstract: Precipitation promoters, which are an organic compound having one or more linear aliphatic hydrocarbon groups having not less than 10 carbon atoms, wherein the aliphatic hydrocarbon group has not less than 20 carbon atoms in total are useful for precipitating an organic compound protected by an organic group having one or more aliphatic hydrocarbon groups having not less than 10 carbon atoms from a solvent.

Abstract: Using a morpholino nucleotide wherein 5?-hydroxy group or a hydroxy group present on the substituent of the 5?-hydroxy group is protected by a protecting group having an alkyl group having not less than 10 and not more than 300 carbon atoms and/or an alkenyl group having not less than 10 and not more than 300 carbon atoms as a starting material, a method capable of efficiently producing the morpholino oligonucleotide in a high yield by a liquid phase synthesis can be provided.

Abstract: Methods of culturing cells capable of producing desired proteins to obtain the proteins by use of a medium from which biological components are excluded as much as possible are provided. Specifically, a culture method characterized by culturing while maintaining a specific amino acid in a culture solution at a high concentration, and a cell culture fed-batch medium for use in the method are provided.

Abstract: A rolled graphite sheet includes a rod-shaped body and a graphite sheet having a length of 1 m or more and a width shorter than the length. The graphite sheet is wound around the rod-shaped body and is rolled in a length direction. When a length direction-end of the graphite sheet is pulled with a force of 1.5 N/cm in a direction parallel to a tangent of a cross-sectional circle of the rolled graphite sheet while fixing the rod-shaped body, the end moves 5 mm or less in the direction parallel to the tangent of the circle.

Abstract: The present invention aims to provide a more stable and efficient method for producing oligonucleotide, particularly, oligonucleotide having various functional groups linked to the 3?-terminal and the like.

Abstract: Oligonucleotides may be produced by a process, including (1) condensing a nucleoside, nucleotide or oligonucleotide (a) or the like wherein a 5?-hydroxy group is not protected and a nucleoside, nucleotide or oligonucleotide (b) wherein a 5?-hydroxy group is protected in a non-polar solvent to give a reaction solution containing a phosphite triester product (c); (3) oxidizing or sulfurizing the phosphite triester product (c) to give a reaction solution containing an oligonucleotide (d) wherein the 5?-hydroxy group is protected; (4) deprotecting the oligonucleotide (d) to give a reaction solution containing an oligonucleotide (e) wherein the 5?-hydroxy group is not protected; and (6) adding a polar solvent to the reaction solution containing the oligonucleotide (e) and purifying the oligonucleotide (e) by solid-liquid separation or extraction.

Abstract: An electrically power assisted bicycle includes an electric motor that generates an assist force assisting human power of a rider, a detachable battery that supplies electric power to the electric motor, a headlight, and an operation panel including a display that displays information, a power button that turns on or off the electrically power assisted bicycle, an illuminance sensor that outputs a signal in accordance with received light, and a controller configured or programmed to control the headlight to be on or off. The power button and the illuminance sensor are located close to each other on or in the operation panel. After a predetermined time period passes after the controller is activated by the power button being pressed by the rider, the controller starts controlling the headlight to be on or off in accordance with the signal output by the illuminance sensor.