Abstract: The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.

Abstract: The present invention relates to biocompatible polymers suitable for drugs and gene delivery, and producing methods thereof. The present invention also enables the creation of compounds with diverse structures by a concise method. The present invention relates to polycyclic iminoether compounds having different functional groups in both sides, such as a pentafluorophenyl group at one end and an azide group at the other end, derivatives thereof and producing methods thereof.

Abstract: A method, computer system, and a computer program product are provided for determining precise location of a target vehicle dynamically. Data relating a target vehicle is obtained to determine the target vehicle's position and route. The data relates to said target vehicle's speed and general moving and directional position. An estimate is calculated based on information about target vehicle movement using speed and traffic congestion and based on position of the target vehicle. Information is obtained about movement of a plurality of other vehicles in proximity of the target vehicle. An elapsed time difference is determined between progress of movement of said target vehicle and a real-time progress of said plurality of vehicles progress. An effectiveness estimate is calculated and the target vehicle's precise position is determined based on the effectiveness estimate.

Abstract: An optical identifier including a recording surface, a plurality of deflection cells each of which has recorded thereon a range in which light to be diffracted is deflected, at least one spatial phase modulator which fills a space between the deflection cells on the recording surface, and a deposition layer which covers part or all of the recording surface. The deflection cells has a spatial frequency expressed in a form of a relief structure and are discretely formed on the recording surface at regular intervals away from each other. A variable color image is recorded by pixels defined by the deflection cells. The spatial phase modulator has thereon a distribution of phase differences recorded in a form of heights of the relief structure. The spatial phase modulator modulates a phase of light outputted from a point light source and displays a reproduced image.

Abstract: A caulking pin (15) is inserted into a mounting hole (21) provided in a metal case body (3), and the end portion of the caulking pin (15) is thermally caulked with a welding tip (24) to form a mold forming portion (17). A surplus absorption recess (31) is formed by enlarging the opening end of the mounting hole (21), and surplus resin is absorbed. The surplus absorption recess (31) is positioned inside a region of the mold forming portion (17). Therefore, the amount of molten surplus resin that protrudes outward from the welding tip (24) in the thermal caulking process is reduced.

Abstract: Provided are a hot dip galvanized steel sheet comprising a base steel sheet wherein the base steel sheet has a predetermined chemical composition, and contains ferrite: 50% or less, retained austenite: 30% or less, tempered martensite: 5% or more, fresh martensite: 10% or less, and pearlite and cementite in total: 5% or less, remaining structures consist of bainite, and a number ratio of tempered martensite with a Mn concentration profile satisfying [Mn]b/[Mn]a>1.2 and [Mn]a/[Mn]<2.0 ([Mn] is the Mn content in the base steel sheet, [Mn]a is the average Mn concentration in the tempered martensite, and [Mn]b is the Mn concentration at the interfaces of different phases of the tempered martensite and ferrite phase and bainite phase) is 0.2 or more with respect to the total number of tempered martensite, and a method for producing the same.

Abstract: The present invention provides a composition for transdermal administration comprising a nucleic acid. Specifically, the present invention provides a composition for transdermal administration comprising a nucleic acid, the nucleic acid comprising RNA, wherein the composition is administered by an administration method comprising spraying the composition to the surface of a target tissue, and the spraying of the composition is performed by pressurization of the composition, whereby the composition is sprayed toward the target tissue and penetrates the surface of the target tissue.

Abstract: The present disclosure provides an outer net blade member capable of forming an outer net blade capable of shaving hair more efficiently, the outer net blade formed using the outer net blade member, and an electric razor including the outer net blade. The outer net blade member according to the present disclosure is capable of forming the outer net blade provided on the electric razor. The outer net blade member includes a cuttable region in which multiple blade holes each in a substantially hexagonal shape are formed in rows in a first direction and a second direction orthogonal to the first direction. The blade holes are formed in a state of forming a row in the second direction in which the blade holes adjacent to each other in the second direction are shifted from each other in position in the first direction.

Abstract: The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.

Abstract: Provided are a hot dip galvanized steel sheet comprising a base steel sheet wherein the base steel sheet has a predetermined composition and contains ferrite: 0% to 50%, retained austenite: 0% to 30%, tempered martensite: 5% or more, fresh martensite: 0% to 10%, and pearlite and cementite in total: 0% to 5%, remaining structures consist of bainite, when defining a region having a hardness of 90% or less of the hardness at a position of ¼ thickness to the base steel sheet side from an interface of the base steel sheet and a hot dip galvanized layer as a “soft layer”, there is a soft layer having a thickness of 10 ?m or more at the base steel sheet side from the interface, the soft layer contains tempered martensite, and an increase rate in a thickness direction of an area % of tempered martensite from the interface to the inside of the base steel sheet inside the soft layer is 5.0%/?m or less, and a method for producing the same.

Abstract: A hot dip galvanized steel sheet includes a base steel sheet and a hot dip galvanized layer on at least one surface of the base metal steel sheet, wherein the base steel sheet has a predetermined chemical composition, and contains, by volume fraction, ferrite: 0% to 50%, retained austenite: 0% to 30%, tempered martensite: 5% or more, fresh martensite: 0% to 10%, and pearlite and cementite in total: 0% to 5%, when there are remaining structures, the remaining structures consist of bainite, a concentration of B atoms at prior austenite grain boundaries is 2.0 atm % or more, and an average effective crystal grain size is 7.0 ?m or less, and a method for producing the same.

Abstract: The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.

Abstract: A hot dip galvanized steel sheet includes a base steel sheet and a hot dip galvanized layer on at least one surface of the base metal steel sheet, wherein the base steel sheet has a predetermined chemical composition, and contains, by volume fraction, ferrite: 0% to 50%, retained austenite: 0% to 30%, tempered martensite: 5% or more, fresh martensite: 0% to 10%, and pearlite and cementite in total: 0% to 5%, when there are remaining structures, the remaining structures consist of bainite, a concentration of B atoms at prior austenite grain boundaries is 2.0 atm % or more, and an average effective crystal grain size is 7.0 ?m or less, and a method for producing the same.

Abstract: A simulation apparatus includes a machine learning device for learning a change in a machining route in machining of a workpiece. The machine learning device observes data indicating the changed machining route and data indicating a machining condition of the workpiece as a state variable, and also acquires determination data for determining whether or not a cycle time obtained by simulation using the changed machining route is appropriate, and learns by associating the machining condition of the workpiece with the change in the machining route, using the state variable and the determination data.

Abstract: A zinc-plated steel sheet includes a steel sheet having a predetermined chemical composition and a zinc-plated layer. In the steel sheet, steel microstructures in a range of ? thickness to ? thickness, having the center at ¼ thickness from a steel sheet surface, include, by vol %, ferrite: 0% to 10%, bainite: 0% to 30%, tempered martensite: 50% or more, fresh martensite: 0% to 10%, retained austenite: more than 10% and 30% or less, and pearlite: 0% to 5%. In the zinc-plated steel sheet, the amount of hydrogen emitted when the steel sheet is heated to 200° C. from room temperature after removal of the zinc-plated layer is 0.40 ppm or less per mass of the steel sheet, the tensile strength is 1470 MPa or more, and no cracking occurs in a U-shape bending test where a stress equivalent to 1000 MPa is applied for 24 hours.

Abstract: An electrolyte solution for an alkali metal-sulfur-based secondary battery, an alkali metal-sulfur-based secondary battery, and a module containing the alkali metal-sulfur-based secondary battery. The electrolyte solution includes a positive electrode containing a carbon composite material that contains a carbon material and a sulfur-containing positive electrode active material. The carbon material has a pore volume ratio (micropores/mesopores) of 1.5 or higher. The electrolyte solution contains a fluorinated ether represented by the following formula (1): R11—(OR12)n11—O—R13. In the formula, R11 and R13 are the same as or different from each other, and are each an alkyl group optionally containing a fluorine atom, with at least one of R11 or R13 containing a fluorine atom; R12 is an alkylene group optionally containing a fluorine atom; and n11 is 0, 1, or 2.

Abstract: Provided are a hot dip galvanized steel sheet comprising a base steel sheet and a hot dip galvanized layer on at least one surface of the base metal steel sheet, wherein the base steel sheet has a predetermined chemical composition and contains, by volume fraction, ferrite: 0% to 50%, retained austenite: 6% to 30%, bainite: 5% or more, tempered martensite: 5% or more, fresh martensite: 0% to 10%, and pearlite and cementite in total: 0% to 5%, a number density of tempered martensite with a circle equivalent diameter of 5.0 ?m or more is 20/1000 ?m2 or less, and an area ratio of fresh martensite with a circle equivalent diameter of 2.0 ?m or more after imparting 5% plastic strain is 10% or less, and a method for producing the same.

Abstract: An optical assembly includes a spacer layer which is translucent or transparent; an image forming reflector which has a reflective layer being formed at least in a first region of the spacer layer; and a protective layer which is laminated over the spacer layer and the image forming reflector and the protective layer being translucent or transparent. The spacer layer is made of a polyolefin or/and a polymer containing an aryl group. The image forming reflector includes a visible image which is authenticatable. The image forming reflector has an individual information record in which a code is stored in the form of a plurality of removed linear segments. The image forming reflector has white level regions and a black level region in planar view. Each of the white level regions has the removed linear segments formed therein. The black level region is interposed between the white level regions.

Abstract: A zinc-plated steel sheet of an aspect of the present invention includes a steel sheet having a predetermined chemical composition and a zinc-plated layer. In the steel sheet, steel microstructures in a range of ? thickness to ? thickness, having the center at ¼ thickness from a steel sheet surface, include, by vol %, ferrite: 0% to 10%, bainite: 0% to 20%, tempered martensite: 70% or more, fresh martensite: 0% to 10%, retained austenite: 0% to 10%, and pearlite: 0% to 5%. In the zinc-plated steel sheet, the amount of hydrogen emitted when the steel sheet is heated to 200° C. from a room temperature after removal of the zinc-plated layer is 0.40 ppm or less per mass of the steel sheet, the tensile strength is 1470 MPa or more, and no cracking occurs in a U-shape bending test where a stress equivalent to 1000 MPa is applied for 24 hours.

Abstract: An optical identifier including a recording surface, a plurality of deflection cells each of which has recorded thereon a range in which light to be diffracted is deflected, at least one spatial phase modulator which fills a space between the deflection cells on the recording surface, and a deposition layer which covers part or all of the recording surface. The deflection cells has a spatial frequency expressed in a form of a relief structure and are discretely formed on the recording surface at regular intervals away from each other. A variable color image is recorded by pixels defined by the deflection cells. The spatial phase modulator has thereon a distribution of phase differences recorded in a form of heights of the relief structure. The spatial phase modulator modulates a phase of light outputted from a point light source and displays a reproduced image.