Abstract: The present invention provides a composition that controls pharmacokinetics. Specifically, the present invention provides: a composition for controlling pharmacokinetics, the composition containing a polyvalent cation as an active ingredient; and a method for controlling pharmacokinetics using the polyvalent cation.

Abstract: A polymer compound selected from a homopolymer of (a) and a block copolymer of (b). (a) A homopolymer comprising a polyether segment having a side chain including a primary amine. (b) A block copolymer of a polyether segment having a side chain including a primary amine, and a poly(ethylene glycol) chain.

Abstract: A numerical controller according to the present invention stores comparative relationship between parameters related to setting of the numerical controller, extracts data having comparative relationship among parameters related to the setting of the numerical controller based on the stored comparative relationship, and causes a display to display the data having the comparative relationship in association with each other.

Abstract: An inspection device (1) inspects an amount of dielectric particles contained in a sample liquid. The inspection device includes a dielectric collection unit (3), a pump unit (10) and an AC voltage supply unit (11). The dielectric collection unit includes at least one pair of electrodes (41, 42) and a flow channel (13) extending in a predetermined direction on the pair of electrodes. The pump unit is configured to feed the sample liquid to follow the flow channel in the predetermined direction. The AC voltage supply unit is configured to supply, to the pair of electrodes, an AC voltage with a predetermined frequency to cause dielectrophoresis for dielectric particles in the fed sample liquid. The dielectric collection unit includes a plurality of slit regions (Rs) aligned in the predetermined direction between the pair of electrodes. Each of the plurality of slit regions is separated from each other within the flow channel.

Abstract: A complex of mRNA encoding a target gene with RNA oligomers, wherein the RNA oligomers are at least two kinds of RNA oligomers comprising RNA sequences of (a) or (b), the at least two kinds of RNA oligomers are hybridizable respectively with sequences, said sequences being different from each other, in the mRNA sequence, and the complex is formed when a first sequence of the RNA oligomers hybridizes with different mRNA from the second sequence of the RNA oligomers: (a) an RNA sequence which comprises a first sequence consisting of 12-40 bases and being complementary to the mRNA sequence, a linker sequence consisting of 0-100 bases and a sequence which is the same as the first sequence, in this order; and (b) an RNA sequence which comprises a first sequence, which has a 90% or more identity with a sequence consisting of 12-40 bases and being complementary to the mRNA sequence and is hybridizable with mRNA, a linker sequence consisting of 0-100 bases and a second sequence which is the same as the first sequence

Abstract: A hot-dip galvanized steel sheet includes a base steel sheet and a hot-dip galvanized layer formed on at least one surface of the base steel sheet, in which the hot-dip galvanized layer includes Fe in a content of more than 0% to 5% or less, Al in a content of more than 0% to 1.0% or less, and columnar grains formed by a ? phase on the surface of the steel sheet, further, 20% or more of the entire interface between the hot-dip galvanized layer and the base steel sheet is coated with the ? phase, and a ratio of an interface formed between ? grains in which coarse oxides are present among ? grains and the base steel sheet with respect to the entire interface between the ? phase and the base steel sheet in the hot-dip galvanized layer is 50% or less, the base steel sheet has predetermined chemical components and a refined layer in direct contact with the interface between the base steel sheet and the hot-dip galvanized layer, an average thickness of the refined layer is 0.1 to 5.

Abstract: A hot-dip galvanized steel sheet includes a base steel sheet and a hot-dip galvanized layer formed on at least one surface of the base steel sheet, in which the hot-dip galvanized layer includes Fe in a content of more than 0% to 5% or less, Al in a content of more than 0% to 1.0% or less, and columnar grains formed by a ? phase on the surface of the steel sheet, further, 20% or more of the entire interface between the hot-dip galvanized layer and the base steel sheet is coated with the ? phase, and a ratio of an interface formed between ? grains in which coarse oxides are present among grains and the base steel sheet with respect to the entire interface between the ? phase and the base steel sheet in the hot-dip galvanized layer is 50% or less, the base steel sheet has predetermined chemical components and a refined layer in direct contact with the interface between the base steel sheet and the hot-dip galvanized layer, an average thickness of the refined layer is 0.1 to 5.

Abstract: A packet forwarding apparatus includes: a multicast determination unit that determines whether a packet that flows through a virtual network is a multicast communication packet; a multicast mapping information storage unit; a multicast mapping unit that allocates a second multicast address to a first multicast address of a newly generated multicast communication and manages these multicast addresses as a piece of mapping information; and a packet encapsulation unit that encapsulates the packet that flows through the virtual network. The packet encapsulation unit encapsulates the multicast communication packet that flows through the virtual network by using the second multicast address.

Abstract: In a specific thickness range of which center is a ¼ thickness from the surface of a base steel sheet, a volume fraction of a ferrite phase is 0% or more and less than 50%, a volume fraction of the total of a hard structure composed of one or more of a bainite structure, a bainitic ferrite phase, a fresh martensite phase, and a tempered martensite phase is 50% or more, a volume fraction of a retained austenite phase is 0% to 8%, and a volume fraction of the total of a pearlite phase and a coarse cementite phase is 0% to 8%, at an interface between a plating layer and the base steel sheet, a Fe—Al alloy layer is provided, the Fe—Al alloy layer having an average thickness of 0.1 ?m to 2.0 ?m and a difference between a maximum thickness and a minimum thickness in the width direction of the steel sheet being within 0.

Abstract: A hot-dip galvanized steel sheet including: a hot-dip galvanizing layer on at least one side of a base steel sheet, wherein the hot-dip galvanizing layer has a Fe content of more than 0% and 3.0% or less and an Al content of more than 0% and 1.0% or less, the hot-dip galvanized steel sheet including: a Fe—Al alloy layer provided on an interface between the hot-dip galvanizing layer and the base steel sheet, the Fe—Al alloy layer having a thickness of 0.1 ?m to 2.0 ?m, and a difference between a maximum value and a minimum value of the thickness of the Fe—Al alloy layer in a width direction of the base steel sheet being within 0.5 ?m; and a fine-grain layer provided in the base steel sheet and directly in contact with the Fe—Al alloy layer, the fine-grain layer having an average thickness of 0.1 ?m to 5.0 ?m, the fine-grain layer including a ferrite phase with an average grain diameter of 0.1 ?m to 3.

Abstract: A high-strength hot-dip galvanized steel sheet excellent in impact resistance and worked portion corrosion resistance including a hot-dip galvanized plating layer on a steel sheet base material whose tensile strength is 590 MPa or more, wherein the plating layer includes projecting alloy layers being in contact with the steel sheet base material, a number density of the projecting alloy layers is 4 pieces/mm or more, wherein the steel sheet base material includes: a miniaturized layer being directly in contact with the interface between the steel sheet base material and the plating layer; a decarburized layer being in contact with the miniaturized layer; and an inner layer other than the miniaturized layer and the decarburized layer, and one or more kinds of oxides of Si and Mn are contained in layers of the miniaturized layer, the decarburized layer, and the projecting alloy layers.

Abstract: A bracket includes: a recessed portion capable of accommodating a bushing; and a mount portion to be mounted on a vehicle-body-side component, on which a stabilizer bar is to be mounted via the bushing. The recessed portion has a pair of opposed portions opposed to each other. The pair of opposed portions have an intermediate portion and a portion nearer to an opening than the intermediate portion, and a distance between the pair of opposed portions is less at the portion nearer to the opening than at the intermediate portion.

Abstract: There is provided a hot-dip galvanized steel sheet with a microstructure in a ? thickness to ? thickness range whose middle is a ¼ thickness from a surface of a base steel sheet, the microstructure contains ferrite phase is 50% or more and 97% or less by volume fraction, and a predetermined phase wherein at an interface between a hot-dip galvanizing layer and the base steel sheet, a Fe—Al alloy layer has an average thickness of 0.1 ?m to 2.0 ?m, and a difference between a maximum thickness and a minimum thickness in a steel sheet width direction is within 0.5 ?m, and in a fine-grain layer directly brought into contact with the Fe—Al alloy layer, the fine-grain has a difference between a maximum thickness and a minimum thickness of the fine-grain layer in the steel sheet width direction is within 2.0 ?m.

Abstract: A high-strength hot-dip galvanized steel sheet contains predetermined amounts of C, Si, Mn, P, S, N, O, sol. Al, Ti, and B, 0.1 to 1.5 mass % of Cr+2×Mo, and a balance in a form of Fe and inevitable impurities. A steel structure includes, in area %, ferrite: 1 to 50%, martensite: 20 to 70%, residual austenite: 0 to 5%, pearlite: 0 to 5%, MA and cementite having 0.2 ?m or more grain size: 0 to 5% in total, and a balance in a form of bainite. A number density of MA or cementite having 0.2 ?m or more grain size and isolated in ferrite or bainite grains is 100 pcs/1000 ?m2 or less, and an average hardness of martensite is in a range from 330 to 500 Hv.

Abstract: An inspection device (1) inspects an amount of dielectric particles contained in a sample liquid. The inspection device includes a dielectric collection unit (3), a pump unit (10) and an AC voltage supply unit (11). The dielectric collection unit includes at least one pair of electrodes (41, 42) and a flow channel (13) extending in a predetermined direction on the pair of electrodes. The pump unit is configured to feed the sample liquid to follow the flow channel in the predetermined direction. The AC voltage supply unit is configured to supply, to the pair of electrodes, an AC voltage with a predetermined frequency to cause dielectrophoresis for dielectric particles in the fed sample liquid. The dielectric collection unit includes a plurality of slit regions (Rs) aligned in the predetermined direction between the pair of electrodes. Each of the plurality of slit regions is separated from each other within the flow channel.

Abstract: An electrolyte solution for an alkali metal-sulfur-based secondary battery, an alkali metal-sulfur-based secondary battery, and a module containing the alkali metal-sulfur-based secondary battery. The electrolyte solution includes a positive electrode containing a carbon composite material that contains a carbon material and a sulfur-containing positive electrode active material. The carbon material has a pore volume ratio (micropores/mesopores) of 1.5 or higher. The electrolyte solution contains a fluorinated ether represented by the following formula (1): R11—(OR12)n11—O—R13. In the formula, R11 and R13 are the same as or different from each other, and are each an alkyl group optionally containing a fluorine atom, with at least one of R11 or R13 containing a fluorine atom; R12 is an alkylene group optionally containing a fluorine atom; and n11 is 0, 1, or 2.

Abstract: A hot-dip galvanized steel sheet wherein the hot-dip galvanized steel sheet comprises a base steel sheet and a hot-dip galvanized layer, a ferrite phase is, by volume fraction, 40% or more and 97% or less in a range of ? thickness to ? thickness centered at a position of ¼ thickness from the surface of the base steel sheet, a hard structure is 3% or more in total, wherein the hot-dip galvanized steel sheet has the hot-dip galvanized layer in which Fe is 5.0% or less and Al is 1.0% or less, and columnar grains formed of a ? phase is 20% or more in an entire interface between the plated layer and the base steel sheet on the surface of the base steel sheet in which a ratio of a volume fraction of the hard structure in a surface layer range of 20 ?m depth in a steel sheet direction from an interface between the hot-dip galvanized layer and the base steel sheet is 0.10 times or more to 0.

Abstract: An inspection device (1) inspects an amount of dielectric particles contained in a sample liquid. The inspection device includes a dielectric collection unit (3), a pump unit (10) and an AC voltage supply unit (11). The dielectric collection unit includes at least one pair of electrodes (41, 42) and a flow channel (13) extending in a predetermined direction on the pair of electrodes. The pump unit is configured to feed the sample liquid to follow the flow channel in the predetermined direction. The AC voltage supply unit is configured to supply, to the pair of electrodes, an AC voltage with a predetermined frequency to cause dielectrophoresis for dielectric particles in the fed sample liquid. The dielectric collection unit includes a plurality of slit regions (Rs) aligned in the predetermined direction between the pair of electrodes. Each of the plurality of slit regions is separated from each other within the flow channel.

Abstract: A simulation apparatus includes a machine learning device for learning a change in a machining route in machining of a workpiece. The machine learning device observes data indicating the changed machining route and data indicating a machining condition of the workpiece as a state variable, and also acquires determination data for determining whether or not a cycle time obtained by simulation using the changed machining route is appropriate, and learns by associating the machining condition of the workpiece with the change in the machining route, using the state variable and the determination data.

Abstract: The present invention provides a functionalized mRNA including mRNA and double-stranded RNA including at least one RNA oligomer hybridized with mRNA. Functionalized mRNA is provided according to this configuration.