Abstract: Example implementations relate to automated ticket classification and response generation. In an example, historical tickets, each including at least one text field, are received, and an embedding model is applied to generate at least one embedding for each historical ticket. The historical tickets are clustered in a plurality of clusters. For each cluster, keywords are extracted from the text fields of each historical ticket in the cluster and a cluster-specific feature matrix is generated. A ticket is received, and at least one feature embedding is generated for the ticket. A similar cluster is determined for the ticket based on similarity between the at least one feature embedding for the ticket and the at least one cluster-specific feature embedding for each cluster in the plurality of clusters. A generative model is applied to generate one or more response steps based on historical response steps and to generate a response output.

Abstract: Disclosed herein are compounds with protein phosphatase 2A agonizing activity. In some embodiments, the compounds may be used in the treatment of cellular disorders, including cancer. In some embodiments, the compounds are used to treat colorectal cancer, including FOLFOX resistant colorectal cancer.

Abstract: Systems and methods for automatically generating and updating a customized marketing campaign are disclosed. An example may involve: receiving a query in natural language form associated with a marketing campaign; generating, based on the query, a list of filters each associated with a corresponding customer attribute; determining a list of target customers based on the list of filters and at least one user input regarding the list of filters; and transmitting the list of target customers to a computing device for creating or updating the marketing campaign.

Abstract: Systems and methods for automatically recommending market locations and store assortments based on customer persona are disclosed. An example may involve: receiving a recommendation request; determining a persona basket including a list of relevant products based on the recommendation request; determining a list of customers having a customer persona associated with the persona basket; computing, for each location area, a persona concentration score indicating a concentration of customers of the customer persona in the location area; generating, based on the persona concentration scores, recommendation data regarding the customer persona; and transmitting the recommendation data to a computing device.

Abstract: The instant invention describes biisoquinoline compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.

Abstract: The instant invention describes biisoquinoline compounds having therapeutic activity, and methods of treating dis-orders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.

Abstract: The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., pancreatic cancer, colon cancer, brain cancer) by increasing DNA damage, reducing nucleotide synthesis, and reducing base excision repair (BER).

Abstract: The invention features compositions and methods that are useful for the treatment of neoplasia by reducing base excision repair (BER). Such compositions are useful, for example, for enhancing the efficacy of known chemotherapeutics, such as DNA alkylating agents. In particular, the invention features agents that mimic the interaction of APC with pol-?. Such agents reduce the activity of long patch- and single nucleotide-base extension repair pathways.

Abstract: The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., breast cancer) by increasing DNA damage and reducing base excision repair (BER).

Abstract: The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., pancreatic cancer, colon cancer, brain cancer) by increasing DNA damage, reducing nucleotide synthesis, and reducing base excision repair (BER).

Abstract: The invention features compositions and methods that are useful for the treatment of neoplasia (e.g., breast cancer) by increasing DNA damage and reducing base excision repair (BER).

Abstract: The invention features compositions and methods that are useful for the treatment of neoplasia by reducing base excision repair (BER). Such compositions are useful, for example, for enhancing the efficacy of known chemotherapeutics, such as DNA alkylating agents. In particular, the invention features agents that mimic the interaction of APC with pol-?. Such agents reduce the activity of long patch- and single nucleotide-base extension repair pathways.