Patents by Inventor Scheffer Tseng

Scheffer Tseng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9198939
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 1, 2015
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Publication number: 20150335771
    Abstract: Disclosed herein, are methods of preparing sterilized amniotic tissues. Further disclosed herein, are methods of using the sterilized amniotic tissues.
    Type: Application
    Filed: August 5, 2015
    Publication date: November 26, 2015
    Inventors: Scheffer TSENG, Ek Kia TAN
  • Patent number: 9175066
    Abstract: Disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of I?I, wherein the transfer of the heavy chain of I?I is catalyzed by TSG-6. Further disclosed herein, in certain embodiments, is an HC•HA complex comprising hyaluronan and a heavy chain of I?I, wherein the transfer of the heavy chain of I?I is catalyzed by the TSG-6 like protein. Additionally, disclosed herein are methods of manufacturing said complex and methods of use thereof.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: November 3, 2015
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He
  • Patent number: 9161954
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: October 20, 2015
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Patent number: 9161956
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 20, 2015
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Patent number: 9161955
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 20, 2015
    Assignee: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Publication number: 20150203814
    Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent stem cells. Also described are methods of expanding stem cells on a substrate comprising an HC-HA complex. Also described are isolated and expanded stem cells produced by the methods and uses thereof, including stem cell therapy, as niche cells for supporting other types of stem cells, or as bioreactors for the production of HC-HA complexes. Also described are uses of HC-HA complexes as a carrier for stem cells.
    Type: Application
    Filed: December 22, 2014
    Publication date: July 23, 2015
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer TSENG, Szu-Yu CHEN, Suzhen ZHANG
  • Publication number: 20150166624
    Abstract: Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (I?I). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.
    Type: Application
    Filed: July 10, 2013
    Publication date: June 18, 2015
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Hua He, Sean Tighe, Suzhen Zhang, Ying-Tieng Zhu
  • Patent number: 9006192
    Abstract: Described herein are methods and compositions for stimulating proliferation of cells that express adherent junctions and cease proliferation, for example, human corneal endothelial cells, by downregulation of certain cell-cell junctions. In one embodiment, downregulation is achieved using RNA interference, and contacting the cells with mitogenic growth factors and an agent that elevates intracytoplasmic cAMP. Furthermore, described herein are methods of isolating human corneal endothelial cells from keratocytes, and methods of preserving and maintaining viability of human corneal endothelial cell aggregates. Also described are surgical grafts comprising human corneal endothelial cells that have been isolated, optionally stored, and transiently contacted with an agent that downregulates expression of p 120, and a biocompatible support.
    Type: Grant
    Filed: September 27, 2007
    Date of Patent: April 14, 2015
    Assignee: TissueTech, Inc.
    Inventors: Scheffer Tseng, Wei Li, Yingting Zhu
  • Patent number: 8940294
    Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent stem cells. Also described are methods of expanding stem cells on a substrate comprising an HC-HA complex. Also described are isolated and expanded stem cells produced by the methods and uses thereof, including stem cell therapy, as niche cells for supporting other types of stem cells, or as bioreactors for the production of HC-HA complexes. Also described are uses of HC-HA complexes as a carrier for stem cells.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: January 27, 2015
    Assignee: Tissuetech, Inc.
    Inventors: Scheffer Tseng, Szu-Yu Chen, Suzhen Zhang
  • Publication number: 20140342014
    Abstract: Disclosed herein, are methods of preparing sterilized amniotic tissues. Further disclosed herein, are methods of using the sterilized amniotic tissues.
    Type: Application
    Filed: August 24, 2012
    Publication date: November 20, 2014
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan
  • Patent number: 8865233
    Abstract: Compositions containing about 0.6% to about 20% of tea tree oil are described. Some compositions are in the form of solutions, suspensions, spray, lotions, gels, pastes, medicated sticks, balms, cleansers (including shampoos and soaps), creams, or ointments. Also described are compositions and methods for use in treating ocular Demodex infestations and related conditions using such compositions.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: October 21, 2014
    Assignee: Tissuetech, Inc.
    Inventors: Ying-Ying Gao, Scheffer Tseng
  • Patent number: 8865232
    Abstract: The present invention relates to a method for treating a disorder chosen from ocular Demodex, Demodex-induced blepharitis, rosacea, acne, and meibomian gland dysfunction in a patient in need thereof, comprising administering to the patient a compositions comprising a therapeutically effective amount of a substance chosen from at least one of an isoprenoidal essential oil such as Tea Tree Oil; Terpinen-4-ol; (+)-Carvone; alpha-Terpineol; Cardinene; d-Carvone; 1-Carvone; gamma-Terpinene; alpha-Terpinene; 1,8-Cineole; alpha-Terpineol; para-Ci mene; alpha-Pinene; Limonene; (R)-(+)-Limonene; alpha-Thugene; Eucalyptol; (+)-Ledene; Cuminic Aldehyde; and Myrcene; the administration comprising contacting or scrubbing an affected area of skin or hair, or eyelid margin and lashes of the patient with the composition; also disclosed are a method for treating mange and mite infestations on a mammalian animal; and kits for in-office and at home treatments of the disorders.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: October 21, 2014
    Assignee: TissueTech, Inc.
    Inventors: Ying-Ying Gao, Scheffer Tseng
  • Publication number: 20140147511
    Abstract: Disclosed herein, are methods of preparing fetal support tissue powders. Further disclosed herein, are methods of using the fetal support tissue powder product.
    Type: Application
    Filed: June 8, 2012
    Publication date: May 29, 2014
    Applicant: TISSUE TECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan, Lorraine Chua
  • Publication number: 20140112998
    Abstract: Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated HC-HA complex.
    Type: Application
    Filed: April 27, 2012
    Publication date: April 24, 2014
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan, Hua He
  • Publication number: 20140106448
    Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent cells (e.g., MSCs and ASCs) using a first culture in a suitable 2-dimensional substrate and a second culture in a suitable 3-dimensional substrate containing the basement membrane component and ROCK inhibitors. Also described are multipotent cell cultures made by the methods. Multipotent cell cultures as described may be used for transplantation or as niche cells for supporting other types of stem cells.
    Type: Application
    Filed: April 30, 2012
    Publication date: April 17, 2014
    Applicant: TissueTech, Inc.
    Inventors: Szu-yu Chen, Scheffer Tseng
  • Publication number: 20130344163
    Abstract: Disclosed herein, in certain instances, are tissue grafts derived from UCAM. Further disclosed herein, in certain instances, are use for tissue grafts derived from UCAM.
    Type: Application
    Filed: March 13, 2013
    Publication date: December 26, 2013
    Inventors: Scheffer TSENG, Ek Kia TAN, Amy TSENG
  • Publication number: 20130251684
    Abstract: Provided herein are methods of isolating and expanding a plurality of multipotent stem cells. Also described are methods of expanding stem cells on a substrate comprising an HC-HA complex. Also described are isolated and expanded stem cells produced by the methods and uses thereof, including stem cell therapy, as niche cells for supporting other types of stem cells, or as bioreactors for the production of HC-HA complexes. Also described are uses of HC-HA complexes as a carrier for stem cells.
    Type: Application
    Filed: March 1, 2013
    Publication date: September 26, 2013
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Szu-Yu Chen, Suzhen Zhang
  • Publication number: 20130156863
    Abstract: Disclosed herein, in certain instances, are tissue grafts derived from chorion or amnio-chorion. Further disclosed herein, in certain instances, are use for tissue grafts derived from chorion or amnio-chorion.
    Type: Application
    Filed: June 30, 2011
    Publication date: June 20, 2013
    Applicant: TISSUETECH, INC.
    Inventors: Scheffer Tseng, Ek Kia Tan, Lorraine Siok May Chua
  • Patent number: 8460714
    Abstract: Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF ? signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: June 11, 2013
    Assignee: TissueTech, Inc.
    Inventors: Scheffer Tseng, Hua He, Wei Li