Patents by Inventor Scheffer Tseng

Scheffer Tseng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070010008
    Abstract: An ex vivo method of expanding animal cells whose differentiation state is controllable by modulating TGF-? signaling includes the steps of: (a) providing an animal subject having cells with a first phenotype; (b) isolating the cells from the animal subject; (c) placing the cells in an ex vivo culture system including a culture vessel having at least one surface and a medium in contact with the at least one surface, the medium being essentially free of intact amniotic membrane and feeder cells; and (d) culturing the cells in the medium under conditions which downregulate TGF-? signaling in the cells and allow the cells to proliferate while maintaining the first phenotype.
    Type: Application
    Filed: June 28, 2006
    Publication date: January 11, 2007
    Inventors: Scheffer Tseng, Hua He, Wei Li
  • Publication number: 20060002900
    Abstract: The present invention relates to a composition for implantation in the subretinal space of an eye, the composition including amniotic membrane, which may be cryopreserved human amniotic membrane, and a plurality of retinal pigment epithelial (RPE) cells or RPE equivalent cells present at the amniotic membrane. The amniotic membrane may be intact, epithelially denuded, or otherwise treated. The invention includes the use of amniotic membrane for the culturing of RPE cells thereon, forming a surgical graft for replacement of Bruch's membrane as a substrate, and for the transplanting of RPE cells to the subretinal space. The composition does not elicit immunological reactions to alloantigens or to RPE specific autoantigens; and exerts anti-inflammatory, anti angiogentic, and anti-scarring effects. The invention includes methods and kits for making or using composites including amniotic membrane and RPE cells. Also disclosed is a device for harvesting RPE cells.
    Type: Application
    Filed: October 6, 2003
    Publication date: January 5, 2006
    Inventors: Susanne Binder, Scheffer Tseng
  • Publication number: 20050026279
    Abstract: The present invention relates to the discovery of a method of enzymatically, consistently and reproducibly, isolating a viable, intact limbal epithelial sheet that retains stem cell characteristics in the basal epithelium. The method comprises the steps of: a) obtaining limbus from a biopsy of a donor eye of a living individual, a living-related individual, or from a cadaveric eye, the limbus comprising limbal epithelium and an underlying stroma; b) contacting the limbus with a solution comprising Dispase 2, for a period of time and under conditions sufficient to loosen a limbal epithelial sheet from the stroma, thereby forming a loosely adherent limbal epithelial sheet; and c) mechanically separating the loose epithelial sheet from the underlying stroma, thereby isolating a substantially intact, viable, limbal epithelial sheet.
    Type: Application
    Filed: April 28, 2004
    Publication date: February 3, 2005
    Inventors: Scheffer Tseng, Edgar Espana