Abstract: A camera system may capture object activity with a field of view comprising one or more regions and identify and selectively output captured image data based on the one or more regions.

Abstract: Compounds for activating invariant natural killer T cells (iNKT) cells are provided. Compounds according to certain embodiments activate iNKT cells and induce an increase in the production of one or more cytokines, such as IFN-?, IL-2, IL-4, IL-6 and TNF?. In some embodiments, activated iNKT cells are used to selectively reduce the presence of or eliminate inflammatory senescent cells, such as senescent cells having an inflammatory secretome (SASP). Methods for activating iNKT cells by contacting an iNKT cell with an amount of the subject compounds and selectively reducing the presence of or eliminating senescent cells with activated iNKT cells are also described. Compositions for practicing the subject methods are also described.

Abstract: Systems, apparatuses, and methods are described for modifying language and/or recording settings of a computing device based on audio data. Audio data comprising speech may be received by a computing device. The computing device may process the audio data to determine one or more properties of speech of one or more users. Based on the one or more properties of the speech, language settings and/or recording settings may be modified. For example, subtitles may be displayed or removed, accessibility features may be implemented, different content may be displayed, and/or machine translation functions may be activated. Such language and/or recording settings may be stored in a user profile, which may be used by a variety of computing devices.

Abstract: Upon detection of a gesture, a current context of an environment in which the gesture is performed may be determined. The current context may be used to interpret the gesture to determine which of potentially a plurality of devices are to be controlled by the gesture and whether the gesture is configured to control the determined device(s) in the current context. The current context may also be used to determine whether to adjust a threshold for determining whether the gesture is intended as a control command. An aspect of the detected gesture may be compared to the threshold to determine whether the gesture is intended as a control command. If the gesture is intended as a control command, the determined device(s) may be controlled accordingly.

Abstract: The disclosure presents a composite column formwork which utilizes a fiber reinforced polymer (FRP) stay in place container which incorporates horizontally coplanar support chairs bonded to the interior surface, closed ties bonded to the support chairs and a plurality of longitudinal rebar enforcements bonded to the closed ties. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: The disclosure presents a composite concrete structure formwork which comprises stay in place fiberglass profiles and reinforcement to form various building and shelter structures. The structures include an interior container maintained at a set distance within an exterior container to form a void. The void is filled with wet concrete which is allowed to cure. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: The disclosure presents a composite conduit formwork structure which includes a cylindrical outer casing adapted to bond with a cylindrical inner casing which are maintained at a fixed distance apart by a plurality of radial stanchions. The inner casing and outer casing form an interior void which is filled with concrete during manufacture. The outer casing and inner casing remain in place to protect the structure once completed. A novel method of assembly is also provided whereby radial stanchions are rotated between the outer casing and inner casing. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: Provided herein are bifunctional compounds with a moiety (e.g., lenalidomide, thalidomide) that is a binder of an E3 ubiquitin ligase (e.g., Cereblon) and another moiety that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one component of the bifunctional compound is a binder of an E3 ubiquitin ligase (e.g., lenalidomide, thalidomide) and another component of the compound is a binder of the target protein DOT1L in a subject.

Abstract: Disclosed are: (i) methods for identifying leukemia patients who (or leukemia cells that) do not exhibit an MLL-translocation, rearrangement or MLL-partial tandem duplication but who are nonetheless susceptible to treatment with DOT1L inhibitors; and (ii) methods for treating leukemia patients who (or inhibiting proliferation or inducing apoptosis of leukemia cells that) do not exhibit an MLL-translocation, rearrangement or MLL-partial tandem duplication with DOT1L inhibitors. The patients identified as susceptible and the patients (or cells) treated exhibit elevated expression of a IIOX cluster gene or of a HOX cluster-associated gene. Elevated expression of such genes can be measured, e.g.

Abstract: The disclosure presents a composite conduit formwork structure which includes a cylindrical outer casing adapted to bond with a cylindrical inner casing which are maintained at a fixed distance apart by a plurality of radial stanchions. The inner casing and outer casing form an interior void which is filled with concrete during manufacture. The outer casing and inner casing remain in place to protect the structure once completed. A novel method of assembly is also provided whereby radial stanchions are rotated between the outer casing and inner casing. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: The disclosure presents a reconfigurable composite floor formwork which defined by a plurality of interlocking fiberglass panels formed into profiles which may be moved and adapted to provide a concrete form for a floor or ceiling. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: An electrosurgical controller and related methods. At least some of the illustrative embodiments are methods including: placing a distal end of an electrosurgical wand in operational relationship with biological tissue; delivering energy to an active electrode of the electrosurgical wand. During delivering energy, the method may comprise: measuring a value indicative of flow of the energy to the active electrode; summing, over a first predetermined window of time, to create a first value indicative of energy provided to the active electrode; summing, over a second predetermined window of time, to create a second value indicative of energy provided to the active electrode. The method may further comprise: ceasing delivering energy responsive to the first value meeting or exceeding a predetermined value; and ceasing delivering energy responsive to the second value meeting or exceeding a threshold value.

Abstract: The disclosure presents a formwork system which utilizes Fiber Reinforced Polymer (FRP) panels to create modular segments to form and reinforce concrete subgrade structures. The segments may be rearranged and bonded together to conform to intended dimensions of many subgrade structures. The segments are manufactured by cast molding, bonding or vacuum forming. The segments may include integrated FRP stanchions to prevent deflection of the panels during concrete placement. The stanchions also may be used for positioning structural steel or FRP rebar. FRP bars are permanently bonded to the interior sides of the panels inside the segments. In use, the assembled segments are filled with concrete. After the concrete is cured, the segments remain in place and function as external protection and reinforcement for the cured concrete.

Abstract: Disclosed herein are compounds that target SMARCA2 and SMARCA4, causing their degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

Abstract: A financial institution agnostic saving system including a server configured to (i) receive information for a funding source of a user at a first financial institution; (ii) receive information for a saving account of the user at a second financial institution; (iii) receive user saving target information for the user which includes a saving rule for determining when to transfer funds from the funding source to the saving account wherein the saving rule is defined based on an amount spent by the user; (iv) receive transaction information for a transaction by the user from a third financial institution, wherein the transaction information includes the amount spent by the user; and (v) transfer money from the funding source to the saving account according to the saving rule. The system may include a marketplace which allows users to modify user saving target information and/or make purchases with savings.

Abstract: The presently disclosed subject matter relates to the administration of a KMT2D inhibitor for the treatment of a cancer. The present invention is based on the discovery that upon PI3K inhibition, KMT2D activity is upregulated, resulting in an increase in the expression of genes involved in breast cancer cell proliferation and tumor growth. Accordingly, the present invention provides methods for treating a subject that has cancer by administering a therapeutically effective amount of an KMT2D inhibitor.

Abstract: Described herein are antifungal peptoids, the development and characterization of the antifungal peptoids, methods of making the antifungal peptoids, and methods of using the antifungal peptoids. In some embodiments, the antifungal peptoids may be administered to a subject infected with or at risk of being infected with pathogenic fungi including, for example Cryptococcus spp. In some embodiments, the Cryptococcus spp. may include C. neoformans or C. gattii or both.

Abstract: The disclosure presents a composite conduit formwork structure which includes a cylindrical outer casing adapted to bond with a cylindrical inner casing which are maintained at a fixed distance apart by a plurality of radial stanchions. The inner casing and outer casing form an interior void which is filled with concrete during manufacture. The outer casing and inner casing remain in place to protect the structure once completed. A novel method of assembly is also provided whereby radial stanchions are rotated between the outer casing and inner casing. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: The disclosure presents a composite column formwork which utilizes a fiber reinforced polymer (FRP) stay in place container which incorporates horizontally coplanar support chairs bonded to the interior surface, closed ties bonded to the support chairs and a plurality of longitudinal rebar enforcements bonded to the closed ties. All of the components in a preferred embodiment are formed of a fiberglass material.

Abstract: The disclosure presents a formwork system which utilizes Fiber Reinforced Polymer (FRP) panels to create modular segments to form and reinforce concrete subgrade structures. The segments may be rearranged and bonded together to conform to intended dimensions of many subgrade structures. The segments are manufactured by cast molding, bonding or vacuum forming. The segments may include integrated FRP stanchions to prevent deflection of the panels during concrete placement. The stanchions also may be used for positioning structural steel or FRP rebar. FRP bars are permanently bonded to the interior sides of the panels inside the segments. In use, the assembled segments are filled with concrete. After the concrete is cured, the segments remain in place and function as external protection and reinforcement for the cured concrete.