Abstract: Disclosed are: (i) methods for identifying leukemia patients who (or leukemia cells that) do not exhibit an MLL-translocation, rearrangement or MLL-partial tandem duplication but who are nonetheless susceptible to treatment with DOT1L inhibitors; and (ii) methods for treating leukemia patients who (or inhibiting proliferation or inducing apoptosis of leukemia cells that) do not exhibit an MLL-translocation, rearrangement or MLL-partial tandem duplication with DOT1L inhibitors. The patients identified as susceptible and the patients (or cells) treated exhibit elevated expression of a HOX cluster gene or of a HOX cluster-associated gene. Elevated expression of such genes can be measured, e.g.

Abstract: Electrosurgical systems and methods are described herein, the system including an electrosurgical probe with an active electrode disposed near the probe distal end, a system with a power supply for delivery of voltage to the active electrode and a controller that receives and processes a signal from a current sensor and a temperature sensor. The current sensor measures the current output of the power supply and the temperature sensor is adjacent an electrically conductive fluid located at a target site. The controller may be programmed to operate in a low voltage mode that limits the power supply to a low voltage output so as to determine whether the current output from the current sensor is within a current output range. This range is defined by predetermined upper and lower limits that are modified by at least one measured value.

Abstract: An electrosurgical controller and related methods. At least some of the illustrative embodiments are methods including: placing a distal end of an electrosurgical wand in operational relationship with biological tissue; delivering energy to an active electrode of the electrosurgical wand. During delivering energy, the method may comprise: measuring a value indicative of flow of the energy to the active electrode; summing, over a first predetermined window of time, to create a first value indicative of energy provided to the active electrode; summing, over a second predetermined window of time, to create a second value indicative of energy provided to the active electrode. The method may further comprise: ceasing delivering energy responsive to the first value meeting or exceeding a predetermined value; and ceasing delivering energy responsive to the second value meeting or exceeding a threshold value.

Abstract: In one embodiment, an implantable neurostimulator comprises a pulse generator that generates an electrical pulse signal to stimulate a neural structure in a patient, a stimulation lead assembly coupled to the pulse generator for delivering the electrical pulse signal to the neural structure, a plurality of sensors coupled to the pulse generator, and sensor select logic. Each sensor is individually selectable and the sensor select logic selects any two or more of the plurality of sensors for sensing a voltage difference between the selected sensors. In other embodiments, two or more physiologic parameters are sensed. In yet another embodiment, a method comprises sensing intrinsic electrical activity on a person's nerve and stimulating the nerve based on the sensed intrinsic electrical activity of the nerve.

Abstract: In one embodiment, an implantable neurostimulator comprises a pulse generator that generates an electrical pulse signal to stimulate a neural structure in a patient, a stimulation lead assembly coupled to the pulse generator for delivering the electrical pulse signal to the neural structure, a plurality of sensors coupled to the pulse generator, and sensor select logic. Each sensor is individually selectable and the sensor select logic selects any two or more of the plurality of sensors for sensing a voltage difference between the selected sensors. In other embodiments, two or more physiologic parameters are sensed. In yet another embodiment, a method comprises sensing intrinsic electrical activity on a person's nerve and stimulating the nerve based on the sensed intrinsic electrical activity of the nerve.

Abstract: A method and an apparatus for projecting an end of service (EOS) and/or an elective replacement indication (ERI) of a component in an implantable device is provided. The method comprises measuring the measured voltage of the energy storage device, and determining whether the measured voltage is less than a transition voltage. When the measured voltage is less than the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the measured voltage. When the measured voltage is greater than or equal to the transition voltage, determining a time period remaining until an end of service of the energy storage device is based upon a function of the total charge depleted. The transition voltage is a voltage associated with the transition point of non-linearity in the battery voltage depletion curve.

Abstract: A method and an apparatus for determining a time period remaining in a useful life of an energy storage device in an implantable medical device. The method may include measuring a voltage of the energy storage device to produce a measured voltage, and comparing the measured voltage to a transition voltage. While the measured voltage is greater than or equal to the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a function of charge depleted. While the measured voltage is less than the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a higher order polynomial function of the measured voltage. The transition voltage corresponds to a predetermined point on a energy storage device voltage depletion curve representing the voltage across the energy storage device over time.

Abstract: A method is provided including delivering at least one electrical signal to tissue of a patient through an electrode. The method further includes assessing whether a net charge remains on the electrode a predetermined period of time after the delivery of the electrical signal. Systems for delivering such a signal, and assessing whether a net charge remains on the electrode providing the signal, are also provided.

Abstract: An improved stern design for many types of small watercraft to eliminate “tail dragging”, porpoising, oversteer and “slide out”, improve longitudinal tracking, and provide faster planing at lower speeds. This hull extension, consisting of two buoyant sponsons extending astern of the motor output, supports the weight of the entire motor propulsion unit, extends the planing surface, shifts the center of buoyancy rearward, resulting in an ability to maintain an even fore-aft keel in a very lightweight hull. Under acceleration and cruising, high pressure under the extensions along with an improved center of gravity keeps the boat from tail dragging. Interior chines formed as part of the inner lower surface of the sponsons provide straight tracking under power, even without other hydrodynamic aids, and provide resistance to oversteer or “slideout” in turns. The long sponson extensions protect an outdrive system from contact at the stern or sides of the boat.

Abstract: An implantable medical device (IMD) may include a lead circuit including a first node configured to be coupled to a first lead that may be coupled to a first target tissue and including a second node configured to be coupled to a second lead that may be coupled to a second target tissue. The IMD may include an impedance unit that may determine at least one characteristic of coupled energy associated with the lead circuit, where the coupled energy may be produced by a source external to the IMD. The impedance unit may provide an impedance between the first node and the second node, where the impedance is selected based at least in part on a characteristic of the coupled energy. The impedance is selected to reduce the coupled energy or a negative effect associated with functionality of the IMD induced by the coupled energy.

Abstract: A computer tote, such as, for example, a portfolio, case or bag, is provided having a receptacle defining an internal space to receive a computer device. The receptacle includes opposing sides connected by a spine. The computer tote further includes a handle coupled to one of the opposing sides of the receptacle near the spine. The handle is sized and positioned to overlie a back of a user's hand when the hand is received between the handle and the receptacle and fingers of the hand are wrapped around the spine.

Abstract: A carrying bag assembly comprises a bag assembly, a flap, and a first connection system. The bag assembly comprises a front panel, a rear panel, a left side panel, a right side panel, a bottom panel, and a cover panel. The bag assembly defines a bag opening and a connection pocket. The flap defines first and second flap surfaces. The flap may be in one of a first attached configuration, a second attached configuration, and a detached configuration. When in either of the first and second attached configurations, the flap may be moved between a closed configuration and an open configuration. When in one of the attached configurations, either the first or second flap surface is visible when the flap is in the closed configuration. When the flap is in either of the first or the second attached configurations, the first connection system is substantially located within the connection pocket.

Abstract: An implantable medical device (IMD) may include a lead circuit including a first node configured to be coupled to a first lead that may be coupled to a first target tissue and including a second node configured to be coupled to a second lead that may be coupled to a second target tissue. The IMD may include an impedance unit that may determine at least one characteristic of coupled energy associated with the lead circuit, where the coupled energy may be produced by a source external to the IMD. The impedance unit may provide an impedance between the first node and the second node, where the impedance is selected based at least in part on a characteristic of the coupled energy. The impedance is selected to reduce the coupled energy or a negative effect associated with functionality of the IMD induced by the coupled energy.

Abstract: A method, system, and apparatus for implementing a safe mode operation of an implantable medical system using impedance adjustment(s) are provided. A first impedance is provided to a lead. An indication of a possibility of a coupled energy is received. Based upon said indication, a second impedance associated with the lead to reduce the coupled energy is provided.

Abstract: A method, system, and apparatus for implementing a safe mode operation of an implantable medical system using impedance adjustment(s) are provided. A first impedance is provided to a lead. An indication of a possibility of a coupled energy is received. Based upon said indication, a second impedance associated with the lead to reduce the coupled energy is provided.

Abstract: A neurostimulation array comprising a first implantable neurostimulator storing a first identification code in a non-volatile memory and responding to communications including said first identification code, a second implantable neurostimulator storing a second identification code in a non-volatile memory and responding to communications including said second identification code, and a polymer connector attached to said first implantable neurostimulator and said second implantable neurostimulator, thereby forming a neurostimulation array.

Abstract: An improved stern design for many types of small watercraft to eliminate “tail dragging”, porpoising, oversteer and “slide out”, improve longitudinal tracking, and provide faster planing at lower speeds. This hull extension, consisting of two buoyant sponsons extending astern of the motor output, supports the weight of the entire motor propulsion unit, extends the planing surface, shifts the center of buoyancy rearward, resulting in an ability to maintain an even fore-aft keel in a very lightweight hull. Under acceleration and cruising, high pressure under the extensions along with an improved center of gravity keeps the boat from tail dragging. Interior chines formed as part of the inner lower surface of the sponsons provide straight tracking under power, even without other hydrodynamic aids, and provide resistance to oversteer or “slideout” in turns. The long sponson extensions protect an outdrive system from contact at the stern or sides of the boat.

Abstract: A method sensing at least two physiological parameters and, for each of the at least two physiological parameters, generating a first series of signals representative of the physiological parameter sensed over a first time period, storing each of said first series of signals as a time sequence data stream, and determining when a physiological event has occurred in a patient. The method further comprises analyzing each of said time sequence data streams for a predetermined time interval preceding the occurrence of a physiological event to determine at least one marker as a predictor of the event, and again sensing the physiological parameters. Furthermore, the method comprises generating a second series of signals representative of the physiological parameter sensed, analyzing each of the second series of signals to determine whether the marker is present, and stimulating a cranial nerve when the marker is present in the second series of signals.

Abstract: Methods, devices and systems for neural stimulation using a short-pulse stimulation are described. Using a waveform that generates a sufficiently large capacitive current density in the tissue surrounding a nerve allows neural stimulation at one hundredth the power of a charge injection stimulation. A capacitive discharge may be used to generate the short-pulse stimulation waveform. Short pulse stimulation may be used to generate parasthesia, particularly for treatment of chronic pain.