Abstract: A means and method for preparing vesicles and freestanding two-dimensional assemblies using aqueous two-phase systems (ATPS) is described. The surface tension of the ATPS is sufficient to support the assembly of various types of particles, and provide the advantage of being biocompatible with DNA and other types of biological molecules that may be used in the assembly. Vesicles are formed by mixing chemically dissimilar compounds in appropriate concentrations and at a temperature sufficient to form a monophasic mixture. This mixture is then heated above the temperature at which the polymer mixture is monophasic, added to a lipid film, and allowed to hydrate at this elevated temperature.

Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

Abstract: The invention relates to substituted polycyclic aryl and heteroaryl pyrazinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

Abstract: Novel 2,4,5-triaryl substituted imidazole compounds and compositions for use in therapy of CSBP/RK/p38 mediated diseases.

Abstract: The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

Abstract: A method, system and computer program product for securing decrypted files in a shared environment. A filter driver in a kernel space may be configured to control service requests to encrypted files stored in a shared area, e.g., a shared directory on a disk unit, accessible by multiple users. The filter driver may receive a service request to open an encrypted document in the shared area issued from an authorized user. Upon receiving the encrypted data, the filter driver may decrypt the encrypted data. The filter driver may subsequently store the decrypted data in a file in a non-shared area, e.g., a non-shared directory. The non-shared area may be accessible only by the authorized user that requested access to the encrypted file. By storing the decrypted data in a file in the non-shared area, a file once decrypted may be protected in a file sharing environment.

Abstract: A method and system for control of key pair usage in a computer system is disclosed. The method and system comprise creating key pair material for utilization with an embedded security chip of the computer system. The key pair material includes tag data. The method and system further includes determining whether the key pair material is bound to the embedded security chip based on the tag data.

Abstract: A method and system for binding a device to a planar is disclosed. According to the preferred embodiment of the method and system of the present invention, a programmable memory chip is provided on the planar and the device is detachably attached to the planar. The method and system further includes using the programmable memory chip to bind the device to the planar.

Abstract: The present invention is to novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of Caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.