Patents by Inventor Scott A. Small
Scott A. Small has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230104357Abstract: The present disclosure relates to methods and compositions for elevating and stabilizing retromer for treating and/or preventing Alzheimer's disease and other neurodegenerative diseases or disorders. Additionally, the disclosure relates to gene therapy combined with a pharmacological retromer chaperone therapy for treating and/or preventing Alzheimer's disease (AD), and other neurodegenerative diseases or disorders such as Parkinson's Disease (PD), amyotrophic lateral sclerosis (ALS), neuronal ceroid lipofuscinosis (NCL), and transmissible spongiform encephalopathies (TSEs or prion disease), multiple system atrophy (MSA), as well as tauopathies such as progressive supranuclear palsy (PSP), frontotemporal lobar dementia linked to chromosome 17q21-22 and its subtypes (FTLD-17/FTLD-Tau), and chronic traumatic encephalopathy (CTE).Type: ApplicationFiled: August 14, 2022Publication date: April 6, 2023Applicants: The Trustees of Columbia University in the City of New York, THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.Inventors: Scott A. Small, Gregory A. Petsko
-
Patent number: 11608650Abstract: A railing system having a number of spaced apart support bases and a railing is provided. The railing includes a number of vertically extending stanchions connected to the support bases and a number of horizontally extending members extending between the vertically extending stanchions. The railing is configured to be shifted relative to the support bases between a stored position and an erected position. The railing is automatically secured in the erected position when the railing is shifted from the stored position to the erected position.Type: GrantFiled: October 17, 2019Date of Patent: March 21, 2023Inventors: Brent Edward Smith, Matthew Scott Small
-
Publication number: 20230021959Abstract: The present disclosure relates to methods and compositions for elevating and stabilizing retromer for treating and/or preventing Alzheimer's disease and other neurodegenerative disorders. Additionally, the disclosure relates to adenoviral based therapy for treating Alzheimer's disease (AD), and other neurodegenerative conditions such as Parkinson's Disease (PD), neuronal ceroid lipofuscinosis (NCL), and transmissible spongiform encephalopathies (TSEs or prion disease), multiple system atrophy (MSA), Down's syndrome, and hereditary spastic paraplegia, as well as tauopathies such as progressive supranuclear palsy (PSP), frontotemporal lobar dementia linked to chromosome 17q21-22 and its subtypes (FTLD-17/FTLD-Tau), Lewy Body Disease (LBD), amyotrophic lateral sclerosis (ALS), frontal-temporal degeneration (FTD), ALS-FTD, and chronic traumatic encephalopathy (CTE).Type: ApplicationFiled: December 7, 2020Publication date: January 26, 2023Applicants: The Trustees of Columbia University in the City of New York, Cornell University, Meiragtx UK II LimitedInventors: Scott A. SMALL, Gregory PETSKO, Rebecca COX, Samuel D. WAKSAL, Alexandria FORBES, Yasir H. QURESHI
-
Publication number: 20220051801Abstract: A method for classifying neurological disease status is described. The method includes acquiring, by a data preprocessor logic, patient image data. The method further includes generating, by a trained artificial neural network (ANN), a classification output based, at least in part, on the patient image data. The classification output corresponds to a neurological disease status of the patient. The trained ANN is trained based, at least in part, on longitudinal source data.Type: ApplicationFiled: October 29, 2021Publication date: February 17, 2022Inventors: Xinyang FENG, Frank PROVENZANO, Scott A. SMALL
-
Publication number: 20220044360Abstract: An exemplary system, method, and computer-accessible medium for detection of functional disorder(s) or aging progression of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the functional disorder(s) or aging progression of the patient(s) based on the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map which can be a full dosage Gd enhanced cerebral blood volume map(s). The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), and/or (ii) a Gd-free MRI scan(s). Functional disorder(s) or age progression can include a neurodegenerative disease, a neuropsychiatric disease, a neurodevelopment disorder or aging.Type: ApplicationFiled: June 15, 2021Publication date: February 10, 2022Inventors: JIA GUO, SCOTT A. SMALL
-
Publication number: 20210383507Abstract: An exemplary system, method, and computer-accessible medium for detection of structural disorder(s) of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the structural disorder(s) of the patient(s) based on a GD contrast of the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). The Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s). Structural disorder(s) can include Stroke, tumor, trauma, infection, Multiple sclerosis and/or other inflammatory disease.Type: ApplicationFiled: June 15, 2021Publication date: December 9, 2021Inventors: JIA GUO, SCOTT A. SMALL
-
Publication number: 20210150671Abstract: An exemplary system, method, and computer-accessible medium for generating a gadolinium (“Gd”) enhanced map(s) of a portion(s) of a patient(s), can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), and generating the Gd enhanced map(s) based on the MRI information using a machine learning procedure(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The full dosage Gd enhanced map(s) can be a full dosage Gd enhanced cerebral blood volume map(s). The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). A Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s).Type: ApplicationFiled: August 24, 2020Publication date: May 20, 2021Inventors: JIA GUO, SCOTT A. SMALL
-
Patent number: 10846858Abstract: A technology which enables identifying, via a computer, a vessel in a third image. The third image is obtained from a subtraction of a second image from a first image. The second image and the first image are aligned within an imaging space. The first image is post-contrast. The second image is pre-contrast. The technology enables determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image. The technology enables obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value. The technology enables applying, via the computer, a filter onto the fourth image. The technology enables generating, via the computer, a filter mask based on the fourth image.Type: GrantFiled: February 4, 2019Date of Patent: November 24, 2020Assignee: The Trustees of Columbia University in the City of New YorkInventors: Scott A. Small, Frank A. Provenzano, Usman A. Khan
-
Publication number: 20200048920Abstract: A railing system having a number of spaced apart support bases and a railing is provided. The railing includes a number of vertically extending stanchions connected to the support bases and a number of horizontally extending members extending between the vertically extending stanchions. The railing is configured to be shifted relative to the support bases between a stored position and an erected position. The railing is automatically secured in the erected position when the railing is shifted from the stored position to the erected position.Type: ApplicationFiled: October 17, 2019Publication date: February 13, 2020Inventors: Brent Edward Smith, Matthew Scott Small
-
Patent number: 10538929Abstract: An automated safety rail system for use on an elevated surface or for temporarily blocking off a restricted area, the automated safety rail system broadly includes primary support structures, horizontally extending support structures, an actuator for shifting the support structures between a disengaged and an engaged configuration, and an electronic control system.Type: GrantFiled: March 15, 2017Date of Patent: January 21, 2020Assignee: Leading Edge Safety, LLCInventors: Brent Edward Smith, Matthew Scott Small, Travis Michael Budenbender
-
Publication number: 20190378275Abstract: A technology which enables identifying, via a computer, a vessel in a third image. The third image is obtained from a subtraction of a second image from a first image. The second image and the first image are aligned within an imaging space. The first image is post-contrast. The second image is pre-contrast. The technology enables determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image. The technology enables obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value. The technology enables applying, via the computer, a filter onto the fourth image. The technology enables generating, via the computer, a filter mask based on the fourth image.Type: ApplicationFiled: February 4, 2019Publication date: December 12, 2019Inventors: Scott A. Small, Frank A. Provenzano, Usman A. Khan
-
Patent number: 10198817Abstract: A technology which enables identifying, via a computer, a vessel in a third image. The third image is obtained from a subtraction of a second image from a first image. The second image and the first image are aligned on an imaging space. The first image is post-contrast. The second image is pre-contrast. The technology enables determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image. The technology enables obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value. The technology enables applying, via the computer, a filter onto the fourth image. The technology enables generating, via the computer, a filter mask based on the fourth image.Type: GrantFiled: April 17, 2015Date of Patent: February 5, 2019Assignee: The Trustees of Columbia University in the City of New YorkInventors: Scott A. Small, Frank A. Provenzano, Usman A. Khan
-
Publication number: 20180266127Abstract: An automated safety rail system for use on an elevated surface or for temporarily blocking off a restricted area, the automated safety rail system broadly includes primary support structures, horizontally extending support structures, an actuator for shifting the support structures between a disengaged and an engaged configuration, and an electronic control system.Type: ApplicationFiled: March 15, 2017Publication date: September 20, 2018Inventors: Brent Edward Smith, Matthew Scott Small, Travis Michael Budenbender
-
Publication number: 20180258656Abstract: A railing system having a number of spaced apart support bases and a railing is provided. The railing includes a number of vertically extending stanchions connected to the support bases and a number of horizontally extending members extending between the vertically extending stanchions. The railing is configured to be shifted relative to the support bases between a stored position and an erected position. The railing is automatically secured in the erected position when the railing is shifted from the stored position to the erected position.Type: ApplicationFiled: March 10, 2017Publication date: September 13, 2018Inventors: Brent Edward Smith, Matthew Scott Small
-
Publication number: 20180228422Abstract: Methods and systems for measuring brain function of a person are disclosed. In some embodiments, the methods include the following: providing a database including digital image files that define intersecting sinusoidal functions; conducting matching trials including displaying a first image selected from the digital image files for a first amount of time, displaying no images for a second amount of time, and displaying both the first image and a second image, prompting the person to identify the first image, recording whether the person correctly identified the first image, and recording an amount of time to complete the matching trial; and conducting recognition trials including displaying an image selected from the digital image files, prompting the person to identify whether the image was displayed in the matching trials, recording whether the person correctly identified whether the image was displayed, and recording an amount of time to complete the recognition trial.Type: ApplicationFiled: September 15, 2015Publication date: August 16, 2018Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Adam M. BRICKMAN, Scott A. SMALL, Lok-Kin YEUNG
-
Publication number: 20170039714Abstract: A technology which enables identifying, via a computer, a vessel in a third image. The third image is obtained from a subtraction of a second image from a first image. The second image and the first image are aligned on an imaging space. The first image is post-contrast. The second image is pre-contrast. The technology enables determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image. The technology enables obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value. The technology enables applying, via the computer, a filter onto the fourth image. The technology enables generating, via the computer, a filter mask based on the fourth image.Type: ApplicationFiled: April 17, 2015Publication date: February 9, 2017Applicant: The Trustees of Columbia University in the City of New YorkInventors: Scott A. Small, Frank A. Provenzano, Usman A. Khan
-
Patent number: 9387263Abstract: Described is a transgenic mouse with two transgenes, each of which transgene comprises a DNA sequence encoding a dominant negative form of RbAp48 protein, wherein the expression of the dominant negative form of RbAp48 is spatially restricted to the forebrain by a CaM Kinase IIa promoter and wherein the expression of the dominant negative form of RbAp48 is controlled by tetracycline-controlled transcriptional activation. Also provided are methods for evaluating in the transgenic mouse the potential therapeutic effect of an agent for slowing, inhibiting or preventing age-related memory decline in a mammalian subject.Type: GrantFiled: August 2, 2012Date of Patent: July 12, 2016Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Scott A. Small, Ilias Pavlopoulos, Eric R. Kandel
-
Publication number: 20150361063Abstract: The present invention provides pharmaceutical compositions and related methods for stabilizing retromer in cells.Type: ApplicationFiled: August 21, 2015Publication date: December 17, 2015Inventors: Dagmar Ringe, Gregory A. Petsko, Scott A. Small, Vincent Mecozzi
-
Publication number: 20150161357Abstract: A social factor evaluation system for reducing hospital readmissions of discharged patients has a database module, an application module, and an analysis module. The database module stores a navigable social factors evaluation and receives social factors evaluation data inputted by a user. the analysis module performs analytics of the inputted data.Type: ApplicationFiled: December 4, 2014Publication date: June 11, 2015Inventors: Roy Scott Small, Steve Brown, Ann Tweed
-
Publication number: 20140294798Abstract: Described is a transgenic mouse with two transgenes, each of which transgene comprises a DNA sequence encoding a dominant negative form of RbAp48 protein, wherein the expression of the dominant negative form of RbAp48 is spatially restricted to the forebrain by a CaM Kinase IIa promoter and wherein the expression of the dominant negative form of RbAp48 is controlled by tetracycline-controlled transcriptional activation. Also provided are methods for evaluating in the transgenic mouse the potential therapeutic effect of an agent for slowing, inhibiting or preventing age-related memory decline in a mammalian subject.Type: ApplicationFiled: August 2, 2012Publication date: October 2, 2014Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Scott A. Small, Ilias Pavlopoulos, Eric R. Kandel