Abstract: The present invention provides pharmaceutical compositions and related methods for stabilizing retromer in cells.

Abstract: A social factor evaluation system for reducing hospital readmissions of discharged patients has a database module, an application module, and an analysis module. The database module stores a navigable social factors evaluation and receives social factors evaluation data inputted by a user. the analysis module performs analytics of the inputted data.

Abstract: Described is a transgenic mouse with two transgenes, each of which transgene comprises a DNA sequence encoding a dominant negative form of RbAp48 protein, wherein the expression of the dominant negative form of RbAp48 is spatially restricted to the forebrain by a CaM Kinase IIa promoter and wherein the expression of the dominant negative form of RbAp48 is controlled by tetracycline-controlled transcriptional activation. Also provided are methods for evaluating in the transgenic mouse the potential therapeutic effect of an agent for slowing, inhibiting or preventing age-related memory decline in a mammalian subject.

Abstract: The present invention provides pharmaceutical compositions and related methods for stabilizing retromer in cells.

Abstract: A miniaturized mouthpiece for repositioning the user's mandible, thereby creating an edge to edge relationship of the user's anterior teeth, without covering or extending to the user's posterior teeth. This miniaturized mouthpiece may be formed from a substantially trapezoidal mouthpiece blank having major and minor sides that are substantially parallel to one another. These major and minor sides may be connected by two equal length non-parallel sides. This blank will typically have a gently curved and raised contact area that follows the curvature of the user's anterior dental arches. The mouthpiece blank will often be made of a thermoplastic material, so that upon application of heat, the blank can be deformed around the user's maxillary central incisors and often the user's maxillary lateral incisors as well, thus creating a mouthpiece that does not cover the user's molars or premolars, yet which creates an interocclusal gap when worn.

Abstract: An athlete's mouthguard containing at least one hologram that has been selected for an ability to project or convey various attributes such as wellness, strength, flexibility, focus, endurance, and balance, or other traits to otherwise stabilize and harmonize the user's body. The hologram need not contain a recognizable team insignia or recognizable advertising logo, and indeed the hologram need not necessarily be visible to outsiders when the mouthguard is worn.

Abstract: Disclosed herein are methods for treating a disease involving ?-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce ?-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce ?-synucleic aggregation; or (3) a compound which inhibits ?-synucleic aggregation in an amount effective to reduce ?-synucleic aggregation. Also disclosed are methods for reducing the amount of ?-synucleic aggregation in a brain cell using (1) a compound which reduces the amount of polyamines in an amount effective to reduce ?-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce ?-synucleic aggregation; or (3) a compound which inhibits ?-synucleic aggregation in an amount effective to reduce ?-synucleic aggregation. Disclosed herein are also compounds which can be used in the above described methods.

Abstract: An adapter includes a first arm and a second arm that is pivotably connected to the first arm. A first portion of the first and second arms cooperate to form a contour which generally matches a contour of a portion of a bicycle frame. A second portion of the first and second arms are constructed to engage one another such that, during a clamping process, the adapter engages the bicycle frame with a desired gripping pressure. Preferably, the gripping pressure is less than a pressure that would crush or otherwise deform the frame of the bicycle.

Abstract: This invention provides a method for increasing the expression of RbAp48 protein in a eukaryotic cell comprising introducing into the cell an agent which specifically increases the expression of RbAp48 protein in the cell. This invention also provides a method for treating a subject afflicted with age-related memory decline comprising administering to the subject a therapeutically effective amount of an agent which specifically increases the expression of RbAp48 protein in the cells of the subject's brain. This invention further provides a method for determining whether an agent causes an increase in the expression of RbAp48 protein. Finally, this invention provides a method for determining whether an agent causes an increase in the activity of RbAp48 protein.

Abstract: This invention provides a method for treating a mammalian subject afflicted with a disorder associated with reduced neurogenesis in the subject's hippocampal dentate gyrus which comprises administering to the subject a therapeutically effective amount of a compound which increases cerebral blood volume in the subject's hippocampal dentate gyrus by a percentage greater than that by which it increases the cerebral blood volume in the subject's hippocampal CA1 region, thereby treating the subject.

Abstract: A system and method for opening the blood-brain barrier in the brain of a subject is disclosed. In some embodiments, a region of the brain of a subject is targeted for opening; and a focused ultrasound beam is applied through the skull of the subject to the targeted region to open the blood-brain barrier in the brain of the subject.

Abstract: An adapter includes a first arm and a second arm that is pivotably connected to the first arm. A first portion of the first and second arms cooperate to form a contour which generally matches a contour of a portion of a bicycle frame. A second portion of the first and second arms are constructed to engage one another such that, during a clamping process, the adapter engages the bicycle frame with a desired gripping pressure. Preferably, the gripping pressure is less than a pressure that would crush or otherwise deform the frame of the bicycle.

Abstract: This invention provides a method for determining whether an agent causes an increase in the expression of a retromer complex protein. This invention further provides a method for determining whether an agent causes an increase in the activity of a retromer complex. This invention also provides a method for increasing the expression of a retromer complex protein in a cell. This invention provides a method for treating a subject afflicted with Alzheimer's disease. This invention further provides a pharmaceutical composition as well as an article of manufacture.

Abstract: The present invention provides a method and a system for guiding people in an emergency. More specifically, the present invention provides a method and system using a laser for guiding people away from an area of danger, and for guiding emergency personal to an area of danger. The system includes a pair of dissimilar visible laser beams generated by at least one laser emitting device. The system also includes an invisible laser for rescue personnel. The visible dissimilar laser beams are generated substantially parallel to each other to direct evacuees away from an area of danger via the shortest and safest route in the event of an emergency.

Abstract: This invention provides a method for determining the amount of blood in a volume of cerebral tissue (cerebral blood volume) in a mammalian subject comprising (a) acquiring a first magnetic resonance image of the volume of tissue in vivo; (b) administering intraperitoneally to the subject a gadolinium-containing contrast agent in an amount greater than about 1 mg per kg body weight and less than about 20 mg per kg body weight; (c) acquiring a second magnetic resonance image of the volume of tissue in vivo, which second image is acquired at least about 15 minutes after, but not more than about 2 hours after, administering the contrast agent; and (d) determining the amount of cerebral blood volume based on the first and second images.

Abstract: The present invention provides a method and a system for guiding people in an emergency. More specifically, the present invention provides a method and system using a laser for guiding people away from an area of danger, and for guiding emergency personal to an area of danger. The system includes a pair of dissimilar visible laser beams generated by at least one laser emitting device. The system also includes an invisible laser for rescue personnel. The visible dissimilar laser beams are generated substantially parallel to each other to direct evacuees away from an area of danger via the shortest and safest route in the event of an emergency.

Abstract: This invention provides a method for determining whether a subject is afflicted with Alzheimer's disease by comparing the metabolic activity of the subject's hippocampal entorhinal cortex with that of a second region of the subject's brain. This invention further provides a method for determining whether a subject is afflicted with Alzheimer's disease by comparing the metabolic activity of the subject's hippocampal entorhinal cortex determined at a first and second time point. Finally, this invention provides a method for determining the amount of blood in a volume of cerebral tissue in vivo, wherein the volume of tissue is 1 mm3 or less.

Abstract: This invention provides a method for determining whether an agent causes a reduction in the expression of a retromer complex protein. This invention further provides a method for determining whether an agent causes a reduction in the activity of a retromer complex. This invention also provides a method for reducing the expression of a retromer complex protein in a cell. This invention provides a method for treating a subject afflicted with Alzheimer's disease. This invention further provides a pharmaceutical composition as well as an article of manufacture. Finally, this invention provides a method for identifying a potential pathogenic nucleic acid transcript with respect to a brain disorder.