Abstract: A rotary method for forming a vaginal applicator. The method includes the steps of providing a forming mandrel, an applicator tube, and die then arranging the forming mandrel to be inside the applicator tube and then engaging the forming mandrel and the applicator tube with the die. The forming mandrel has a first sustaining ridge having a circumferential length and a second sustaining ridge having a circumferential length. The circumferential length of the first sustaining ridge is less than the circumferential length of the second sustaining ridge.

Abstract: A rotary method for forming a vaginal applicator. The method includes the steps of providing a forming mandrel, an applicator tube, and die then arranging the forming mandrel to be inside the applicator tube and then engaging the forming mandrel and the applicator tube with the die. The forming mandrel has a first sustaining ridge having a circumferential length and a second sustaining ridge having a circumferential length. The circumferential length of the first sustaining ridge is less than the circumferential length of the second sustaining ridge.

Abstract: An actuator assembly for hand-grippable devices, such as levers for a brake or clutch, triggers, scissor-action tools, etc. The actuator assembly is a lever having a rotation-restriction mechanism, such as a one-way bearing, mounted on a shaft, with a sleeve assembled over the rotation-restriction mechanism and shaft. As the lever is grasped by the fingertips and pulled toward the operator's palm, the sleeve rotates about the shaft axis, thereby allowing the lever to roll from the fingertips toward the base of the fingers near palm of the operator's hand, where the operator has greater strength and control over the lever. The sleeve is prevented from rotating in the reverse direction, so, when the operator releases the lever, the lever slides along toward the fingertips, allowing the operator to slow the motion as desired. The actuator assembly reduces fatigue and loss of control over hand-operated mechanisms.

Abstract: This invention relates to novel compounds having the structural formula Ia or formula Ib: Ia Ib and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of A? related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

Abstract: A composition is provided that includes a ternary electrolyte having a melting point greater than about 150 degree Celsius. The ternary electrolyte includes an alkali metal halide, an aluminum halide and a zinc halide. The amount of the zinc halide present in the ternary electrolyte is greater than about 20 mole percent relative to an amount of the aluminum halide. An energy storage device including the composition is provided. A system and a method are also provided.

Abstract: Microchip devices are provided that include a substrate; a plurality of reservoirs in the substrate, each reservoir defining an internal volume; and a reservoir cap positioned on or in each of the reservoirs bounding the internal volume from an external environment, the reservoir cap being formed of a material that undergoes a phase change upon heating, wherein the internal volume can communicate with the external environment upon heating said reservoir cap to cause said reservoir cap to undergo a phase change and rupture.

Abstract: This invention relates to novel compounds having the structural formula Ia or formula Ib below: (Ia, Ib), and their pharmaceutically acceptable salts, tautomers or in vivo hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of A? related pathologies such as cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

Abstract: The invention relates to 2-aza-bicyclo[2.2.2]octane compounds and uses thereof. Particularly the invention relates to such compounds and their uses as pharmaceuticals in treating pyshoses such as schizophrenia and other diseases, disorders, or conditions.

Abstract: Methods are provided for controlled reservoir opening, including the steps of (a) providing a biocompatible implantable device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir. In another embodiment, the method steps include (a) implanting into a patient a biocompatible device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir.

Abstract: This invention relates to novel compounds having the structural formula (I) and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.

Abstract: The present application relates to internally cyclized naphthamide compounds of the formula Ia (wherein R1a, R1b, R1c, R2, R3, R4, R5, R6, R7, R8, X1, X2, Y, Z, and n are as defined herein), which are useful, for example, for antagonizing the pharmacological actions of the neurokinin 1 (NK1) receptor.

Abstract: A method for teaching an individual to speak correctly using novel visual displays and supporting descriptive material. The visual display comprises a string of discreet visual segments illustrating volume, pace, pitch, melody and tone that guide the individual in creating specific sounds and speech patterns. The visual displays can be published in a book or pamphlet from or in electronic media such as CD, CD-Rom, DVD, or video.

Abstract: Compounds having the general formula wherein R1a, R1b, R1c, R2, R3, R4, R5, R6, R7, R8, X1, X2, Y, Z and n are as defined in the specification, methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.

Abstract: Methods are provided for controlled reservoir opening, including the steps of (a) providing a biocompatible implantable device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir. In another embodiment, the method steps include (a) implanting into a patient a biocompatible device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir.

Abstract: Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substrate; a release system which includes drug molecules for release, the release system being provided in each of the reservoirs; a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

Abstract: A compound having the general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.

Abstract: Microchip delivery devices are provided that control both the rate and time of release of molecules. In one embodiment, an implantable microchip device is provided for the controlled delivery of drug molecules into a patient comprising at least one substrate; a plurality of reservoirs in the substrate; a release system which includes drug molecules for release, the release system being provided in each of the reservoirs; a reservoir cap positioned on or in each of the reservoirs over the release system, the reservoir cap comprising a material that undergoes a phase change in response to a change in temperature; and a heating means capable of selectively causing the phase change independently in each reservoir cap, to release the molecules from the reservoirs. The reservoirs can contain multiple drugs or other molecules in variable dosages. Each of the reservoirs of a single microchip can contain different molecules and/or different amounts and concentrations, which can be released independently.

Abstract: The invention is a method of teaching an individual how to correctly sing a song by using visual display that is displayed to the individual synchronously with the playing of the audio portion of the song. A plurality of visual cues included in the visual display guides the individual in following the musical tones in the song that is played along with the display of the visual cues. The visual display can be made available for use in a variety of ways such as on CDs, on the Internet, and the like. Alternatively, the visual display can be published in a printed publication for use with an audio recording of the song.

Abstract: Microchip delivery devices are provided that control both the rate and time of release of molecules, wherein the device includes a substrate, at least one reservoir in the substrate containing the molecules, and a reservoir cap positioned on the reservoir over the molecules, wherein the molecules are released from the reservoir upon heating or cooling the device or a portion thereof sufficient to rupture the reservoir cap. In a preferred embodiment, the device includes a resistor integrated into the reservoir or mounted near the reservoir, which upon application of an electric current through the resistor, causes at least one of the contents of the reservoir to thermally expand, vaporize, phase change, or undergo a thermally driven reaction, such that the reservoir cap ruptures due to mechanical stress.

Abstract: A rotor assembly for a gas turbine engine including a bearing assembly and a damper sub-assembly that facilitate reducing dynamic motion to the rotor assembly is described. The bearing assembly includes rolling elements positioned between a paired race. The rotor assembly includes a rotor shaft supported by the bearing assembly. The damper sub-assembly is radially outward from the bearing assembly adjacent a sump housing, and includes a damper insert. A predetermined preload force is applied to the rolling elements. An outer race of the bearing assembly distorts to substantially match a distortion pattern of the damper insert.