Abstract: The present invention relates to novel c-MYC mRNA translation modulators, composition and methods of preparation thereof, and uses thereof in the treatment of cancer.

Abstract: Disclosed is a plasma processing apparatus including a processing chamber and a workpiece support disposed in the processing chamber configured to support a workpiece during processing. The apparatus includes a hollow cathode disposed in the processing chamber that is configured to produce a plasma in the processing chamber. The hollow cathode is disposed adjacent to a perimeter of the workpiece support and the workpiece. The apparatus includes a gas distribution system configured to provide process gas to the processing chamber. Methods for processing workpieces are also disclosed.

Abstract: A computer-implemented method comprising: receiving a first input associated with a first entity at a first level of a hierarchy; receiving a second input, associated with a second entity at a second level of the hierarchy, the second entity linked to the first entity within the hierarchy; generating a first low-dimensional feature representation based on the first input, the first low-dimensional feature representation representing the first entity; and generating a second low-dimensional feature representation based on the first input, the second input and the first low-dimensional feature representation, the second low-dimensional feature representation representing the second entity.

Abstract: The presently claimed invention relates to a process for the beneficiation of coal and other hydrophobic materials, wherein a collector composition comprising by-products obtained by hydroformylation of octene isomers as a first component and diesel, kerosene and/or C8-C20 olefins as a second component is used.

Abstract: The present invention is directed to a method for selectively recovering a mineral from an ore applying a promoter being a substituted ethylene diamine. Further, the present invention is directed to the use of said substituted polymeric alkylenediamine to separate a target mineral from an ore.

Abstract: Systems, interfaces, and methods for implementing the systems and interfaces include a dynamic environment generation subsystem that changes objects and subobjects based on locations of the motion sensors and/or the nature, time and/or location of sensed motion and include selection attractive movement as the selection protocol, where a selection object is used to discriminate between selectable objects and attract a target object toward the selection objects, where the direction and speed of the motion controls, discriminates, attracts, and activates the selected objects.

Abstract: A patient interface is configured to deliver a flow of pressurized breathable gas to a patient's airways. The patient interface includes a central portion with an opening configured to deliver the pressurized breathable gas to the patient's nares. A first stabilizing portion extends from the central portion and is structured to engage an outer side of a respective one of the patient's nostrils. A second stabilizing portion is opposite the first stabilizing portion and extends from the central portion. In addition, the second stabilizing surface is structured to engage an outer side of a respective one of the patient's nostrils. The central portion, the first stabilizing portion and the second stabilizing portion cooperate to form a U-shape configured to cradle the patient's nose so that the tip of the patient's nose remains exposed when the patient interface is mounted on the patient's face.

Abstract: Various analyte sensing apparatuses and associated housings are provided. Some apparatuses comprise one or more caps. Some apparatuses comprise a two-part adhesive patch. Some apparatuses comprise one or more sensor bends configured to locate and/or hold a sensor in place during mounting. Some apparatuses utilize one or more dams and/or wells to retain epoxy for securing a sensor. Some apparatuses utilize a pocket and one or more adjacent areas and various transitions for preventing epoxy from wicking to undesired areas of the apparatus. Some apparatuses include heat-sealable thermoplastic elastomers for welding a cap to the apparatus. Related methods of fabricating such apparatuses and/or housings are also provided.

Abstract: A system and method for capturing CO2 from air includes exposing the air to a source of water such that CO2 in the water is below equilibrium with CO2 in the air. The water may be enriched with hydroxides. In a preferred embodiment, the CO2 may be captured along with ammonia that is released from decomposing biomass using an apparatus including a first chamber receiving the water and a second chamber receiving the decomposing biomass. The first and second chambers are connected to allow transmission of air between the chambers while collectively defining an enclosed space from which air cannot escape. As the biomass decomposes, the enclosed air is enriched with CO2 and ammonia such that the CO2 in the water is below equilibrium with CO2 in the air so the water absorbs some of the CO2 in the air within the enclosed space.

Abstract: A sour production fluid mitigation system may at an entry point below an injection sub for a coiled tubing system, pumping an inhibited fluid through pressure control equipment for the coiled tubing system to an exit point. A sour production fluid mitigation system may use a choke guide below the exit point and above a wellhead, maintaining an inhibited fluid pressure at the exit point greater than or equal to a production fluid pressure at a production tree of the wellhead.

Abstract: Various analyte sensing apparatuses and associated housings are provided. Some apparatuses comprise one or more caps. Some apparatuses comprise a two-part adhesive patch. Some apparatuses comprise one or more sensor bends configured to locate and/or hold a sensor in place during mounting. Some apparatuses utilize one or more dams and/or wells to retain epoxy for securing a sensor. Some apparatuses utilize a pocket and one or more adjacent areas and various transitions for preventing epoxy from wicking to undesired areas of the apparatus. Some apparatuses include heat-sealable thermoplastic elastomers for welding a cap to the apparatus. Related methods of fabricating such apparatuses and/or housings are also provided.

Abstract: A patient interface includes a hollow base with an air inlet configured to be connected to an air delivery tube and receive the pressurized flow of respiratory gas. The hollow base further includes a pair of nozzles extending from the hollow base. Each nozzle is configured to receive the pressurized flow of respiratory gas from a respective one of the pair of air outlets. A continuous flexible adhesive strip of material configured to adhere to a side of the patient's nose and support the hollow base and the pair of nozzles on the patient's face to form a sealed airpath from the hollow base to the patient's nasal airways. The hollow base comprises a first portion from which the pair of nozzles extend and a second portion that is attachable to the air delivery tube. The second portion is more rigid than the first portion.

Abstract: Systems and methods for securing communication channels for new user onboarding are disclosed. According to one embodiment, a method may include an onboarding application executed on a new user mobile electronic device: generating a new user cryptographic key pair using secure hardware on the new user mobile electronic device; protecting a new user private key of the new user cryptographic key pair with a new user biometric or passcode and storing the protected new user private key on the new user mobile electronic device; communicating new user information and a new user public key of the new user cryptographic key pair to a backend computer program for an organization; receiving encrypted new user credentials from the backend computer program; retrieving the protected new user private key and unlocking the new user protected private key using the new user biometric or passcode; and decrypting the encrypted new user credentials.

Abstract: Various analyte sensing apparatuses and associated housings are provided. Some apparatuses comprise one or more caps. Some apparatuses comprise a two-part adhesive patch. Some apparatuses comprise one or more sensor bends configured to locate and/or hold a sensor in place during mounting. Some apparatuses utilize one or more dams and/or wells to retain epoxy for securing a sensor. Some apparatuses utilize a pocket and one or more adjacent areas and various transitions for preventing epoxy from wicking to undesired areas of the apparatus. Some apparatuses include heat-sealable thermoplastic elastomers for welding a cap to the apparatus. Related methods of fabricating such apparatuses and/or housings are also provided.

Abstract: The present disclosure provides an attachable external display screen for use on electronic devices. The display screen may be removably mounted onto a surface of an electronic device to provide the user with an additional display screen. The attachable external display screen is lightweight and has a more even weight distribution than other attachable display accessories due to the placement of the mother control board in the mount. The attachable external display screen also provides for a wireless connection to the electronic device.

Abstract: A geothermal heat pump system includes a main heat exchanger, a borehole that extends in a vertical direction through an aquifer, a ground loop and a pump. The main heat exchanger is configured to exchange heat between a ground loop flow and a heat distribution system. The ground loop includes a groundwater heat exchanger, an input pipe and an output pipe. The groundwater heat exchanger is contained within the borehole and includes heat exchange piping. The input pipe delivers the ground loop flow from the main heat exchanger to the heat exchange piping. The output pipe delivers the ground loop flow from the heat exchange piping to the main heat exchanger. The pump drives a groundwater flow in a horizontal direction that is transverse to the vertical direction across the heat exchange piping. Heat exchange occurs between the ground loop flow and the groundwater flow.

Abstract: A downhole cutting tool (13) for perforating a tubular (14) in an oil or gas well comprises a body (4); radially moveable cutting members (3) mounted on the body (4); a helical profiled member (1) rotatable relative to the body (4); and activation members (2) axially movable relative to the body (4). Rotation of the helical profiled member (1) generates axial movement of the activation members (2), and the activation members (2) configured to actuate the cutting members (3) from a retracted configuration to an extended configuration.

Abstract: An interfacing structure is arranged to cooperate with a frame to contact with the skin of a patient. The interfacing structure includes a clip portion joined to a cushioning component. The frame is more rigid than the clip portion and the clip portion is more rigid than the cushioning component.

Abstract: There is provided herein a container with four side wall panels 10, 12, 14, 16, four base panels 36, 38, 40, 42 connected thereto about fold lines and a glue panel 18. The container has an overwrap layer 8 covering the panels 10, 12, 14, 16, 18, 36, 38, 40, 42. The overwrap layer 8 has overhanging portions 70, 72 which overhang the edges of a pair of the base panel portions 38, 42 and are adhered to the other base panel portions 36, 40. There is also provided a method for making such a container and a blank 26 for such a container.

Abstract: A system, method, and computer program product for reducing artifacts in networked simulations using reconciliation with a combined peer-to-peer and authoritative network architecture, comprising obtaining at least one input associated with an authoritative simulation state from a first client device of a plurality of client devices, the first client device executing a first simulation instance, associating a delayed processing penalty with the first client device, the delayed processing penalty providing a minimum acceptable duration that elapses between an initial instance associated with the at least one input by the first client device and a subsequent instance when generating the authoritative simulation state based on the at least one input of the first client device, routing simulation information to the plurality of client devices, the simulation information associated with the authoritative simulation state, and updating one or more simulation instances of the first client device with the simulation