Abstract: Certain aspects of the present disclosure include compounds having Formula (X). Disclosed embodiments also include compositions comprising at least one compound according to the present disclosure, such as from 5% to 70% of at least one compound according to the present disclosure, at a dosage of from 0.1 mg to about 10,000 mg, and further comprising an excipient, an adjuvant, a carrier, and/or at least one additional biologically active compound other than a compound according to the present disclosure. Disclosed compounds and/or can be administered to a subject multiple times per day, such as 1 to 3 times per day, and/or periodically, such as every 2 to 7 days, for a variety of reasons, such as to increase neuronal plasticity, to treat a neurological disease, to treat a neuropsychiatric disease, to elicit a biological response, such as by activating a 5-HT2A receptor, or to increase at least one of translation, transcription, or secretion of neurotrophic factors.

Abstract: A guided circular saw system having a track and a ramp that is connected to a benchtop by a pair of hinge members. Hinge members are formed of a top section, a middle section and a bottom section and facilitate raising and lowering of the track in a quick and easy manner without tools. The track is raised to facilitate placing a workpiece under the track and then the track is lowered in place thereby engaging and holding the workpiece in place. A sled attached to a cutting device and the sled and cutting device slides along the track thereby cutting the workpiece. The track includes sacrificial grip strips that extend along the sides of the track and include an upper layer of material that is rigid and a lower layer of material that is compressible and has a high coefficient of friction and thereby holds the workpiece in place.

Abstract: This disclosure relates to integrated circuit devices that may include a network processor in a data processing die and an on-package memory in a base die. The data processing die may implement one or more network functionalities that may exchange data with low-latency memory, high capacity in the base die. The data processing die may be programmable fabric, which may be dynamically reconfigured during operation.

Abstract: A record processing and storage system is operable to generate data source assignment data by segregating a plurality of data sources into a plurality of data source sets mapped to a corresponding plurality of storage clusters of the record processing and storage system. For each of the plurality of storage clusters, a corresponding subset of a plurality of pages is generated to include only ones of a plurality of records received from data sources included in a corresponding one of the plurality of data source sets, and the corresponding subset of the plurality of pages via storage resources of the each of the plurality of storage clusters. For each of the plurality of storage clusters, deduplication of each page included in the corresponding subset of the plurality of pages is facilitated based on metadata comparisons with other pages included in the corresponding subset of the plurality of pages.

Abstract: Systems and methods for implementing an application programming interface (API) that controls operations of a machine learning tuning service for tuning a machine learning model for improved accuracy and computational performance includes an API that is in control communication the tuning service that: executes a first API call function that includes an optimization work request that sets tuning parameters for tuning hyperparameters of a machine learning model; and initializes an operation of distinct tuning worker instances of the service that each execute distinct tuning tasks for tuning the hyperparameters; executes a second API call function that identifies raw values for the hyperparameters; and generates suggestions comprising proposed hyperparameter values selected from the plurality of raw values for each of the hyperparameters; and executes a third API call function that returns performance metrics relating to a real-world performance of the subscriber machine learning model executed with the propose

Abstract: A modeling system receives, in association with generating a three-dimensional (3D) virtual reset, a selection of a 3D virtual object. The modeling system presents, at a user interface, the 3D virtual object in the 3D virtual reset at a first position. The modeling system receives, via the user interface, an edit to the 3D virtual object in the 3D virtual reset. The modeling system updates the presentation of the 3D virtual reset by showing the edit. The modeling system stores the 3D virtual reset by including, in the 3D virtual reset, information about the 3D virtual object and information about the edit.

Abstract: An adjustable outsert system with a point, a sleeve, and a post when assembled. The system is configured to be inserted into an end of an arrow shaft that comprises a hollow receiving portion. The point can be any type of arrowhead, is axially aligned with the post and the sleeve, and can be of any screw-in type. The post has receiving portion for attachment to the axially aligned end of the point, and comprises provision of cut points to facilitate the adjustment of the weight of the target point to a more precise weight based on the choice of the archer. The sleeve is cylindrical and of a dimension to allow it to be slipped over the end of the post following insertion into the receiving portion of the arrow shaft.

Abstract: According to at least one embodiment, a method, a computer system, and a computer program product for enhanced dynamic braking of a tape storage device during a loss of power is provided. The present invention may include identifying a direction in which tape is moving; identifying a position of the tape; setting brake/coast conditions, wherein the brake/coast conditions comprise a BrakeSelect value of a supply reel and a BrakeSelect value of a take-up reel, based on the identified direction in which the tape is moving and the identified position of the tape; and based upon a detection of a loss of power, applying the set brake/coast conditions to the supply reel and the take-up reel.

Abstract: The present disclosure provides novel synthetic nucleic acids and recombinant adeno-associated virus (rAAV) comprising the same, as well as methods of their use in the treatment of muscular dystrophies associated with a dystrophin mutation. Also provided are pharmaceutical compositions comprising a novel synthetic nucleic acid or rAAV of the invention, and a pharmaceutically acceptable carrier or excipient. Pharmaceutical compositions comprising an rAAV of the invention may be useful in gene therapy for the treatment of dystrophin-associated muscular dystrophies, such as Duchenne muscular dystrophy (DVD). Becker muscular dystrophy (BMD), and X-linked cardiomyopathy.

Abstract: A method includes generating a plurality of pages from a plurality of records received from a plurality of data sources. Deduplication of the plurality of pages is facilitated based on a plurality of page metadata of the plurality of pages based on, for the each page of the plurality of pages. A filtered set of potentially-intersecting pages is identified for each given page as a proper subset of the plurality of pages stored in the page storage system based on first comparison parameters, and an intersecting set of pages that include a row number intersection with the given page is identified as a proper subset of the filtered set of potentially-intersecting pages based on second comparison parameters. Records with records with row numbers included in row number intersections with other pages in the intersecting set of pages are removed from the each page.

Abstract: A telescopic duct for a vehicle, the telescopic duct comprising a first duct fluidly coupled with a heating, ventilation, and air conditioning unit. The first duct comprises a flanged rim, a first body extending outwardly from the flanged rim, at least one stop tab coupled with the first body, and a first gasket. The telescopic duct comprises a second duct slidably coupled with the first duct. The second duct comprises a second body engaged with the first gasket, at least one catch tab coupled with the second body, and a catch pin coupled with the second body. The telescopic duct further comprises a third duct slidably coupled with the second duct. The third duct comprises a second gasket coupled with the third duct, the second gasket engaged with the second duct, and a third body defining a groove, the groove slidably engaged with the catch pin.

Abstract: Systems and methods for an accelerated tuning of hyperparameters of a model supported with prior learnings data include assessing subject models associated with a plurality of distinct sources of transfer tuning data, wherein the assessing includes implementing of: [1] a model relatedness assessment for each of a plurality of distinct pairwise subject models, and [2] a model coherence assessment for each of the plurality of distinct pairwise subject models; constructing a plurality of distinct prior mixture models based on the relatedness metric value and the coherence metric value for each of the plurality of distinct pairwise subject models, identifying sources of transfer tuning data based on identifying a distinct prior mixture model having a satisfactory model evidence fraction; and accelerating a tuning of hyperparameters of the target model based on transfer tuning data associated with the distinct prior mixture model having the satisfactory model evidence fraction.

Abstract: The invention is a system that prevents the opening of a door into a room or other area by an intruder. The system includes an aperture positioned in flooring, the aperture located adjacent to a first side edge and bottom edge of a closed door. The system also includes a block comprising an internal passageway with about the same dimensions as the aperture. The system further includes an elongated pin comprising a first end and a second end, wherein the pin is configured to pass through the block internal passageway and into the aperture. The block is held in position over the aperture when the pin passes through the block internal passageway and into the aperture. When the block is held in position, the closed door is prevented from opening.

Abstract: A disclosed example includes implementing a first worker instance and a second worker instance to operate in parallel; running a first tuning operation via the first worker instance to tune first hyperparameters; running a second tuning operation via the second worker instance using a Bayesian-based optimization to determine a hyperparameter configuration to evaluate next; evaluating the hyperparameter configuration for an external model using a surrogate model; and selecting the hyperparameter configuration for the external model.

Abstract: A record processing and storage system is operable to receive a set of records for storage. The set of records are included in a plurality of pages stored by a page storage system, and each page of the plurality of pages includes a plurality of records in the set of records. Key value-based record distribution data is generated for the set of records based on a plurality of cluster key values of the set of records. A cluster key domain spanned by the plurality of cluster key values is divided into a plurality of key space sub-intervals based on the key value-based record distribution data. The set of records are segregated into a plurality of row subsets corresponding to the plurality of key space sub-intervals. A plurality sets of segments are generated by processing the plurality of row subsets in parallel.

Abstract: A database system operates to: receive, via a communication network, a record stream from a data source that includes a plurality of row data, wherein each of the plurality of row data includes a set of records for storage as relational database rows of at least one database table and further indicates a batch number corresponding to the set of records; add each of the plurality of row data to a pending row data pool; and perform parallelized generation of a plurality of pages from the plurality of row data to each include multiple records of the plurality of row data via a plurality of processing core resources based on each processing core resource in the plurality of processing core resources including power, processing a corresponding subset of the plurality of row data, independently from and in parallel with processing of other subsets of the plurality of row data via other ones of the plurality of processing core resources.

Abstract: Systems and methods for tuning hyperparameters of a model include receiving a tuning request for tuning hyperparameters, the tuning request includes a first and a second objective function for the machine learning model. The first and second objective functions may output metric values that do not improve uniformly. Systems and methods additionally include defining a joint tuning function that is based on a combination of the first and second objective functions; executing a tuning operation; identifying a Pareto efficient frontier curve defined by a plurality of distinct hyperparameter values; applying metric thresholds to the Pareto efficient frontier curve; demarcating the Pareto efficient frontier curve into at least a first infeasible section and a second feasible section; searching the second feasible section of the Pareto efficient frontier curve for one or more proposed hyperparameter values; and identifying at least a first set of proposed hyperparameter values based on the search.

Abstract: Methods and systems for improved analytics are provided. A Software as a Service (SaaS) platform may be implemented as a distributed system using a public infrastructure, such as a public cloud, and an on-premises infrastructure, such as a private cloud. A control plane for the SaaS platform may reside in the public cloud, while a data plane for the SaaS platform may reside in the on-premises private cloud.

Abstract: Disclosed examples include after a first tuning of hyperparameters in a hyperparameter space, selecting first hyperparameter values for respective ones of the hyperparameters; generating a polygonal shaped failure region in the hyperparameter space based on the first hyperparameter values; setting the first hyperparameter values to failure before a second tuning of the hyperparameters; and selecting second hyperparameter values for the respective ones of the hyperparameters in a second tuning region after the second tuning of the hyperparameters in the second tuning region, the second tuning region separate from the polygonal shaped failure region.