Abstract: A projector or system for assisting in a removal of 3D printed molds from a print chamber. The projector is operative to receive a file in a format compatible for a 3D printer. The projector further receives input corresponding to a location of the prototype contained in a powder box and input corresponding to a profile of powder contained across a surface of the associated powder box. Using the location, a portion of the prototype located immediately beneath a surface of powder in the powder box is determined. A distance of the portion to a selected region of the top surface is also determined. A cue is generated based on the distance. The projector generates an image of the extracted layer and projects the image onto the surface of the associated powder box. The image comprises at least one color coded region within a proximity of the portion, where a color of the color coded region is based on the cue.

Abstract: A system and method for jetting a viscous material includes an electronic controller and a jetting dispenser operatively coupled with the electronic controller. The jetting dispenser includes an outlet orifice and a piezoelectric actuator operatively coupled with a movable shaft. The jetting dispenser is under control of the electronic controller for causing said piezoelectric actuator to move the shaft and jet an amount of the viscous material from the outlet orifice. The electronic controller sends a waveform to the piezoelectric actuator to optimize control of the jetting operation.

Abstract: A system and method for jetting a viscous material includes an electronic controller and a jetting dispenser operatively coupled with the electronic controller. The jetting dispenser includes an outlet orifice and a piezoelectric actuator operatively coupled with a movable shaft. The jetting dispenser is under control of the electronic controller for causing said piezoelectric actuator to move the shaft and jet an amount of the viscous material from the outlet orifice. The electronic controller sends a waveform to the piezoelectric actuator to optimize control of the jetting operation.

Abstract: A handheld valve dispenser includes a barrel having proximal and distal ends and a fluid chamber adapted to store a fluid. A dispense tip is coupled to the distal end of the barrel and includes a piercing element and a valve seat. The piercing element is configured to pierce the seal and establish an aperture therethrough when the dispense tip is first coupled to the barrel. A valve stem is received within the fluid chamber and is movable between a closed position in which the valve stem sealingly contacts the valve seat to prevent fluid dispense, and an open position for dispensing fluid. The barrel may include an outer barrel member and a disposable inner barrel liner removably received within the outer barrel member.

Abstract: A handheld valve dispenser includes a barrel having proximal and distal ends and a fluid chamber adapted to store a fluid. A dispense tip is coupled to the distal end of the barrel and includes a piercing element and a valve seat. The piercing element is configured to pierce the seal and establish an aperture therethrough when the dispense tip is first coupled to the barrel. A valve stem is received within the fluid chamber and is movable between a closed position in which the valve stem sealingly contacts the valve seat to prevent fluid dispense, and an open position for dispensing fluid. The barrel may include an outer barrel member and a disposable inner barrel liner removably received within the outer barrel member.

Abstract: A system and method for jetting a viscous material includes an electronic controller and a jetting dispenser operatively coupled with the electronic controller. The jetting dispenser includes an outlet orifice and a piezoelectric actuator operatively coupled with a movable shaft. The jetting dispenser is under control of the electronic controller for causing said piezoelectric actuator to move the shaft and jet an amount of the viscous material from the outlet orifice. The electronic controller sends a waveform to the piezoelectric actuator to optimize control of the jetting operation.

Abstract: A syringe for dispensing liquid materials to a substrate. In one embodiment, the syringe includes a barrel having a first end, a second end, and an interior reservoir. A piston is slidably disposed within the reservoir and is movable to increase or decrease a volume of the interior reservoir near the first end of the barrel. At least a portion of at least one of the barrel, the piston, or the dispensing tip comprises a material selected to maintain operative structural integrity of the dispensing syringe at elevated temperatures.

Abstract: A syringe for dispensing liquid materials to a substrate. In one embodiment, the syringe includes a barrel having a first end, a second end, and an interior reservoir. A piston is slidably disposed within the reservoir and is movable to increase or decrease a volume of the interior reservoir near the first end of the barrel. At least a portion of at least one of the barrel, the piston, or the dispensing tip comprises a material selected to maintain operative structural integrity of the dispensing syringe at elevated temperatures.

Abstract: An apparatus for pulsed dispensing of liquid. The apparatus includes a syringe body structure communicating with an input passage for pressurized actuation air, and communicating with an exit passage for allowing discharge of the liquid. An air input passage flow air controller is operative to increase the flow rate of the input air in accordance with a relationship that depends at least partially on a reduction of liquid volume in the syringe body structure resulting from a previous pulsed dispensing operation.

Abstract: An apparatus for pulsed dispensing of liquid. The apparatus includes a syringe body structure communicating with an input passage for pressurized actuation air, and communicating with an exit passage for allowing discharge of the liquid. An air input passage flow air controller is operative to increase the flow rate of the input air in accordance with a relationship that depends at least partially on a reduction of liquid volume in the syringe body structure resulting from a previous pulsed dispensing operation.

Abstract: An apparatus and method for pulsed dispensing of liquid. The apparatus includes a syringe body structure communicating with an input passage for pressurized actuation air, and communicating with an exit passage for allowing discharge of the liquid. An air input passage flow air controller is operative to increase the flow rate of the input air in accordance with a relationship that depends at least partially on a reduction of liquid volume in the syringe body structure resulting from a previous pulsed dispensing operation.

Abstract: Spinal implants and methods to repair annular defects in intervertebral discs and provide dynamic stability to the spine in the vicinity of a repaired disc are described. Some implants include head and tail portions. In some embodiments, the head portion of an implant is enlarged relative to the tail portion. Some head portions and tail portions are adapted to support adjacent vertebrae and resist collapse of the intervertebral disc. Head portions provide a spacer function to maintain separation between adjacent vertebrae. A tapered portion of some implants engages end plates of adjacent vertebrae to resist forces tending to push the implant out of the intervertebral space. The tail portion of some implants includes a tail flange (which in some embodiments is of similar diameter to the head portion) that abuts extradiscal lips of the adjacent vertebrae and resists forces tending to push the implant deeper into the intervertebral space.

Abstract: An apparatus and method for pulsed dispensing of liquid. The apparatus includes a syringe body structure communicating with an input passage for pressurized actuation air, and communicating with an exit passage for allowing discharge of the liquid. An air input passage flow air controller is operative to increase the flow rate of the input air in accordance with a relationship that depends at least partially on a reduction of liquid volume in the syringe body structure resulting from a previous pulsed dispensing operation.

Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which a nucleus implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.

Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which a nucleus an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.

Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.

Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.

Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.

Abstract: Spinal implants and methods to repair annular defects in intervertebral discs and provide dynamic stability to the spine in the vicinity of a repaired disc are described. Some implants include head and tail portions. In some embodiments, the head portion of an implant is enlarged relative to the tail portion. Some head portions and tail portions are adapted to support adjacent vertebrae and resist collapse of the intervertebral disc. Head portions provide a spacer function to maintain separation between adjacent vertebrae. A tapered portion of some implants engages end plates of adjacent vertebrae to resist forces tending to push the implant out of the intervertebral space. The tail portion of some implants includes a tail flange (which in some embodiments is of similar diameter to the head portion) that abuts extradiscal lips of the adjacent vertebrae and resists forces tending to push the implant deeper into the intervertebral space.

Abstract: The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.