Patents by Inventor Scott Conner
Scott Conner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090270989Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which a nucleus implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.Type: ApplicationFiled: November 19, 2008Publication date: October 29, 2009Applicant: Magellan Spine Technologies, Inc.Inventors: E. Scott Conner, Jay A. Lenker, Khoi Nguyen, Jeffrey J. Valko, Matthew Scott Lake, Peter Gregory Davis
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Publication number: 20090171461Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which a nucleus an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.Type: ApplicationFiled: November 19, 2008Publication date: July 2, 2009Applicant: Magellan Spine Technologies, Inc.Inventors: E. Scott CONNER, Jay A. Lenker, Khoi Nguyen, Jeffrey J. Valko, Matthew Scott Lake, Peter Gregory Davis
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Publication number: 20090149959Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.Type: ApplicationFiled: November 19, 2008Publication date: June 11, 2009Applicant: Magellan Spine Technologies, Inc.Inventors: E. Scott Conner, Jay A. Lenker, Khoi Nguyen, Jeffrey J. Valko, Matthew Scott Lake, Peter Gregory Davis
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Publication number: 20090138084Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.Type: ApplicationFiled: November 19, 2008Publication date: May 28, 2009Applicant: Magellan Spine Technologies, Inc.Inventors: E. Scott CONNER, Jay A. Lenker, Khoi Nguyen, Jeffrey J. Valko, Matthew Scott Lake, Peter Gregory Davis
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Publication number: 20090138015Abstract: Spinal implants are disclosed that can be used for annular repair, facet unloading, disc height preservation, disc decompression, or for sealing a portal through which an intervertebral implant was placed. In some embodiments, an implant is placed within the intervertebral disc space, primarily within the region of the annulus fibrosus. In some embodiments, the implant is expandable. In some embodiments, the implant has a sealing tail structure comprising a tail flange and a linkage. In some embodiments, the sealing tail structure limits the extrusion or expulsion of disc material, either annulus fibrosus or nucleus, into the posterior region of the spine where it could impinge on nerves. In some embodiments, the tail structure is retained in place within the annulus fibrosus by means of an anchor. In some embodiments, the anchor is constructed from multiple components.Type: ApplicationFiled: November 19, 2008Publication date: May 28, 2009Applicant: Magellan Spine Technologies, Inc.Inventors: E. Scott CONNER, Jay A. Lenker, Khoi Nguyen, Jeffrey J. Valko, Matthew Scott Lake, Peter Gregory Davis
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Publication number: 20080071377Abstract: Spinal implants and methods to repair annular defects in intervertebral discs and provide dynamic stability to the spine in the vicinity of a repaired disc are described. Some implants include head and tail portions. In some embodiments, the head portion of an implant is enlarged relative to the tail portion. Some head portions and tail portions are adapted to support adjacent vertebrae and resist collapse of the intervertebral disc. Head portions provide a spacer function to maintain separation between adjacent vertebrae. A tapered portion of some implants engages end plates of adjacent vertebrae to resist forces tending to push the implant out of the intervertebral space. The tail portion of some implants includes a tail flange (which in some embodiments is of similar diameter to the head portion) that abuts extradiscal lips of the adjacent vertebrae and resists forces tending to push the implant deeper into the intervertebral space.Type: ApplicationFiled: March 21, 2007Publication date: March 20, 2008Applicant: Magellan Spine Technologies, Inc.Inventors: E. Scott Conner, Jeffrey Valko
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Publication number: 20070249688Abstract: The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.Type: ApplicationFiled: June 8, 2005Publication date: October 25, 2007Applicant: Eli Lilly and CompanyInventors: Scott Conner, Guoxin Zhu, Jianke Li
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Publication number: 20070106081Abstract: The present invention is directed to compounds represented by the following structural formula, Formula (I), and stereoisomers, pharmaceutically acceptable salts, solvates and hydrates thereof, wherein: (a) R2 is selected from the group consisting of C0-C8 alkyl and C1-4-heteroalkyl; (b) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (c) U is an aliphatic linker wherein one carbon atom of the aliphatic linker is optionally replaced with O, NH or S, and wherein such aliphatic linker is optionally substituted with from one to four substituents each independently selected from R30; (d) Y is selected from the group consisting of C, O, S, NH and a single bond; and (e) E is C(R3)(R4)A or A.Type: ApplicationFiled: December 16, 2004Publication date: May 10, 2007Inventors: Scott Conner, Nathan Mantlo, Guoxin Zhu, Robert Herr
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Publication number: 20070043220Abstract: The present invention is directed to a compound, {2-Methyl-4-[3-methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethylsulfanyl]-phenoxy}-acetic acid and pharmaceutical uses thereof.Type: ApplicationFiled: December 31, 2003Publication date: February 22, 2007Inventors: Scott Conner, Nathan Mantlo, Daniel Mayhugh, Guoxin Zhu
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Publication number: 20060241157Abstract: The present invention is directed to compounds represented by the following structural formula, Formula I: wherein: (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker; (c) Y is selected from the group consisting of O, C, S, NH and a single bond; (d) E is C(R3)(R4)A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamide, sulfonamide and acylsulfonamide; (e) Z1 and Z2 are each independently selected from the group consisting of N, O, and C with the proviso that at least one of Z1 and Z2 is N; (f) Z3 is selected from the group consisting of N, O, and C. (g) R8 is selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C4 alkylenyl and halo; (h) R9 is selected from the group consisting of hydrogen, C1-C4 alkyl, C1-C4 alkylenyl, halo, aryl-C0-C4 alkyl, heteroaryl, C1-C6 allyl, and OR29.Type: ApplicationFiled: December 31, 2003Publication date: October 26, 2006Inventors: Scott Conner, Tianwei Ma, Nathan Mantlo, Daniel Mayhugh, Jeffrey Schkeryantz, Alan Warshawsky, Guoxin Zhu
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Publication number: 20060217433Abstract: The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.Type: ApplicationFiled: February 10, 2004Publication date: September 28, 2006Applicant: Eli Lilly and CompanyInventors: Scott Conner, Lynn Gosset, Jonathan Green, Winton Jones, Nathan Mantlo, Donald Matthews, Daniel Mayhugh, Daryl Smith, Jennifer Vance, Xiaodong Wang, Alan Warshawsky, Leonard Winneroski, Yanping Xu, Guoxin Zhu
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Publication number: 20060217374Abstract: The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in I are defined herein. Also included are compounds, methods of making compounds, and pharmaceutical compositions. The compounds of the present invention are believed to be effective in treating and preventing Syndrome X, Type H diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis, and other disorders related to Syndrome X and cardiovascular diseases.Type: ApplicationFiled: December 31, 2003Publication date: September 28, 2006Inventors: Scott Conner, James Knobelsdorg, Nathan Mantlo, Daniel Mayhugh, Xiaodong Wang, Guoxin Zhu, Jeffrey Schkeryantz
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Publication number: 20060205744Abstract: The present invention is directed to compounds represented by the following structural formula, Formula I: wherein (a) X is selected from the group consisting of a single bond, O, S, S(O)2 and N; (b) U is an aliphatic linker, (c) Y is selected from the group consisting of C, O, S, NH and a single bond; (d) E is C(R3) (R4) A or A and wherein (i) A is selected from the group consisting of carboxyl, tetrazole, C1-C6 alkylnitrile, carboxamidek, sulfonamide and acylsulfonamide; (e) B is selected from the group consisting of S, O, C, and N; (f) Z is selected from the group consisting of N and C; with the proviso that when B is C then Z is N.Type: ApplicationFiled: December 31, 2003Publication date: September 14, 2006Applicant: Eli Lilly and Company Patent DivisionInventors: Scott Conner, Nathan Mantlo, Guoxin Zhu
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Publication number: 20060166983Abstract: The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in (I) are defined herein. Also included are compounds, methods of making compounds, and pharmaceutical compositions. The compounds of the present invention are believed to be effective in treating and preventing Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis, and other disorders related to Syndrome X and cardiovascular diseases.Type: ApplicationFiled: December 31, 2003Publication date: July 27, 2006Inventors: Scott Conner, James Knobelsdorf, Nathan Mantlo, Daniel Mayhugh, Xiaodong Wang, Guoxin Zhu, Jeffrey Schkeryantz, Pierre-Yves Michellys
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Publication number: 20060084663Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I: wherein: (a) R5 is selected from the group consisting of (C1-C6) alkyl, (C1-C6) alkenyl, substituted aryl(C0-C4)alkyl, substituted aryloxy(C0-C4)alkyl, substituted arylthio(C0-C4)alkyl, unsubstituted aryl(C0-C4)alkyl, unsubstituted aryloxy(C0-C4)alkyl, and unsubstituted arylthio(C0-C4)alkyl; (b) T1 is C or N; (c) Q is selected from the group consisting of O, a single bond, O(CH2)q and C; (d) q is 1 or 2; (e) W is selected from the group consisting of O, S, (CH2)rN(R20)(CH2)k, NHSO2, C(O)N(R20)(CH2)r, (CH2)rN(R20)C(O), and SO2; (f) X is CmH2m; (g) m is 0, 1 or 2; (h) A is an functional group selected from the group consisting of carboxyl, C1-C3 alkylnitrile, carboxamide, and (CH2)nCOOR19; and (i) R19 is selected from the group consisting of hydrogen, optionally substituted C1-C4alkyl and optionally substituted arylmethyl.Type: ApplicationFiled: February 13, 2003Publication date: April 20, 2006Applicant: Eli Lilly and Company, Patent DivisionInventors: Scott Conner, Nathan Mantlo, Guoxin Zhu
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Publication number: 20050288321Abstract: The present invention provides kinase inhibitors of Formula (I).Type: ApplicationFiled: March 5, 2003Publication date: December 29, 2005Inventors: Pamela Albaugh, Jochen Ammenn, Timothy Burkholder, Joshu Clayton, Scott Conner, Brian Cunningham, Thomas Engler, Kelly Furness, James Henry, Sushant Malhotra, Mark Joseph Tebbe
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Publication number: 20050250825Abstract: Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H, alkyl or haloalkyl, the polymethylene chain (H), is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubstituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene, R3 is H, alkyl or haloalkyl, R4 is H, alkyl, haloalkyl or a substituted or unsubstituted benzyl, are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.Type: ApplicationFiled: July 14, 2005Publication date: November 10, 2005Inventors: Dawn Brooks, Scott Conner, Samuel Dominianni, Alexander Godfrey, Lynn Gossett, Christopher Rito, Allie Tripp, Alan Warshawsky, Leonard Winneroski, Guoxin Zhu
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Publication number: 20050107449Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I. (Formula I); wherein: (a) R5 is selected from the group consisting of (C1-C6) alkyl, (C1-C6) alkenyl, aryl (C0-C4) alkyl, aryloxy (C0-C4) alkyl, arylthio (C0-C4) alkyl, and further wherein when R5 is alkyl, R5 can optionally combine with W to form a 6 membered cycloheteroalkyl ring that is fused with the oxazole or thiazole ring to which the R5 group is attached; (b) R9 is selected from the group consisting of C1-C5 alkyl, C1-C5 alkenyl, and arylC0-C3alkyl.Type: ApplicationFiled: February 13, 2003Publication date: May 19, 2005Inventors: Scott Conner, James Knobelsdorf, Nathan Mantlo, Jeffrey Schkeryantz, Quanrong Shen, Alan Warshawsky, Guoxin Zhu