Patents by Inventor Scott E. Fraser
Scott E. Fraser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20010046679Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: ApplicationFiled: April 30, 2001Publication date: November 29, 2001Applicant: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Publication number: 20010034033Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: ApplicationFiled: May 23, 2001Publication date: October 25, 2001Applicant: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6277576Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: May 7, 1999Date of Patent: August 21, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6268150Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: December 10, 1999Date of Patent: July 31, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6268149Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: December 6, 1999Date of Patent: July 31, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6258545Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: April 7, 2000Date of Patent: July 10, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6238870Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: December 8, 1999Date of Patent: May 29, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6232295Abstract: A delivery vehicle is described that is capable of being specifically bound to and taken into targeted cells, delivering numerous paramagnetic ions for magnetic resonance imaging (MRI) of the cells. The delivery vehicle comprises a polymeric molecule having a net positive charge complexed with another polymeric molecule having a net negative charge. Cell targeting moieties and MRI contrast agents are attached to one or both of the polymeric molecules. In one embodiment, the polymeric molecule having a net negative charge is a nucleic acid. Thus, the delivery vehicles can be used in clinical protocols in which nucleic acids for gene therapy and agents for MRI contrast are co-transported to specific cells allowing medical imaging monitoring of nucleic acid delivery.Type: GrantFiled: October 12, 1994Date of Patent: May 15, 2001Inventors: Jon Faiz Kayyem, Thomas J. Meade, Scott E. Fraser
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Patent number: 6200761Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: December 6, 1999Date of Patent: March 13, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6180352Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: December 10, 1999Date of Patent: January 30, 2001Assignee: California Insitute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6177250Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: May 7, 1999Date of Patent: January 23, 2001Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6123921Abstract: The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker, which may be either a coupling moiety or a polymer.Type: GrantFiled: June 19, 1998Date of Patent: September 26, 2000Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Scott E. Fraser, Russell E. Jacobs
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Patent number: 6087100Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: October 8, 1997Date of Patent: July 11, 2000Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 6071699Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: June 19, 1998Date of Patent: June 6, 2000Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 5952172Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: June 12, 1997Date of Patent: September 14, 1999Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 5900228Abstract: The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker, which may be either a coupling moiety or a polymer.Type: GrantFiled: July 31, 1996Date of Patent: May 4, 1999Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Scott E. Fraser, Russell E. Jacobs
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Patent number: 5824473Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: June 7, 1995Date of Patent: October 20, 1998Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 5780234Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: September 6, 1996Date of Patent: July 14, 1998Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 5770369Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: June 7, 1996Date of Patent: June 23, 1998Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
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Patent number: 5705348Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.Type: GrantFiled: September 6, 1996Date of Patent: January 6, 1998Assignee: California Institute of TechnologyInventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser