Abstract: The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A system and method for creating a mixed consumable item may include displaying a first set of selectable indicia on a touchscreen, where the indicia may be (i) indicative of respective consumable ingredients and (ii) distinctly positioned relative to one another. A swype gesture may be received from a user via the touchscreen that forms a path extending between a first position and a second position that touches or passes close to multiple selectable indicia. From the first set of consumable ingredients, a plurality of combinations of consumable ingredients most likely to have been intended to be selected by the user based on the path of the swype gesture may be predicted. Selectable predicted combinations of consumable ingredients may be displayed on the touchscreen to enable one of the selectable combinations of consumable ingredients to be selected by the user for mixing by a dispenser of consumable items.

Abstract: Technologies are described herein for creating and editing dynamic graphics via a World Wide Web (“Web”) interface. A Web service is provided for generating dynamic graphics in response to requests received from client computers. In response to requests from client computers, the Web service generates requested dynamic graphics and returns the generated dynamic graphics to the client computers in response to the requests. Parameters may be provided to the Web service indicating a list of text items, a layout type, a visual style, a color, and other aspects of a dynamic graphic. A user interface is also provided for creating and editing a dynamic graphic within a Web browser application.

Abstract: Technologies are described herein for creating and editing dynamic graphics via a World Wide Web (“Web”) interface. A Web service is provided for generating dynamic graphics in response to requests received from client computers. In response to requests from client computers, the Web service generates requested dynamic graphics and returns the generated dynamic graphics to the client computers in response to the requests. Parameters may be provided to the Web service indicating a list of text items, a layout type, a visual style, a color, and other aspects of a dynamic graphic. A user interface is also provided for creating and editing a dynamic graphic within a Web browser application.

Abstract: The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S; A and Y independently are N, or CH.

Abstract: The subject invention pertains to a method, apparatus, and composition of matter for producing near-infrared (near-IR) radiation. The subject invention can incorporate a polymer and a metal-containing compound, wherein the metal-containing compound can incorporate a metal-ligand complex, wherein when the metal-ligand complex becomes excited, energy is transferred from the ligand to the metal, wherein, the energy transferred to the metal by sensitization is emitted as near-infrared radiation. In a specific embodiment, the subject invention relates to a composition of matter having a luminescent polymer and a metal containing compound where the metal containing compound incorporates a metal-ligand complex such that the absorption spectrum of the metal-ligand complex at least partially overlaps with the emission spectrum of the luminescent polymer.

Abstract: The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents.

Abstract: The present invention relates to novel amyloid binding compounds and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted pyrazole derivatives, compositions, and therapeutic uses and processes for making such compounds.

Abstract: The present invention relates to novel amyloid binding compounds and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted indole derivatives, compositions, and therapeutic uses and processes for making such compounds.

Abstract: A method for predicting the contribution of silicon interstitials to n-type dopant transient enhanced diffusion during a pn junction formation is disclosed. Initially, fundamental data for a set of microscopic processes that can occur during one or more material processing operations are obtained. The fundamental data are then utilized to build kinetic models for a set of reactions that contribute substantially to an evolution of n-type dopant concentration and electrical activities. The kinetic models are subsequently applied to a simulator to predict temporal and spatial evolutions of concentration and electrical activity profiles of the n-type dopants.

Abstract: A request is received to enter a background removal mode. A marquee is displayed for specifying a portion of an image to be provided to a foreground extraction engine (“FEA”). The portion of the image defined by the marquee is provided to the FEA. The FEA identifies the foreground and returns it to the application program. The image is displayed with the foreground distinguished from the background. If the marquee is re-sized or re-positioned, the portion of the image defined by the marquee is provided to the FEA. A line segment may be drawn over the background to define a portion of the image for inclusion in the foreground. A line segment may also be drawn over the foreground to define a portion of the image for inclusion in the background. Upon exit of the background removal mode, only the foreground of the image is displayed.

Abstract: Compositions and methods for resisting soil erosion. The compositions comprise a polymer mixed with an organic material. The polymer preferably comprises polyacrylamide or an acrylamide copolymer having anionic functional groups. A second polymer to promote the formation of a film may also be utilized. The organic material comprises natural and synthetic fiber material. The methods of the present invention comprises applying the compositions of the present invention to an area of land sought to be provided with soil erosion resistant properties and thereafter allowing water to mix therewith, as may be supplied or provided naturally by precipitation.

Abstract: Compositions and methods for concomitantly resisting fire and soil erosion. The compositions comprise an aqueous mixture of a polymer mixed with an organic material. The polymer preferably comprises polyacrylamide or a copolymer of polyacrylamide having anionic functional groups. The organic material comprises either cellulose, mulch and/or seed and mulch. The methods of the present invention comprise providing or forming an aqueous mixture of the compositions of the present invention and applying them to an area of land sought to be provided with soil erosion and/or fire resistant properties.

Abstract: Technologies are described herein for creating and editing dynamic graphics via a World Wide Web (“Web”) interface. A Web service is provided for generating dynamic graphics in response to requests received from client computers. In response to requests from client computers, the Web service generates requested dynamic graphics and returns the generated dynamic graphics to the client computers in response to the requests. Parameters may be provided to the Web service indicating a list of text items, a layout type, a visual style, a color, and other aspects of a dynamic graphic. A user interface is also provided for creating and editing a dynamic graphic within a Web browser application.

Abstract: Compositions and methods for concomitantly resisting fire and soil erosion. The compositions comprise an aqueous mixture of a polymer mixed with an organic material. The polymer preferably comprises polyacrylamide or a copolymer of polyacrylamide having anionic functional groups. The organic material comprises either cellulose, mulch and/or seed and mulch. The methods of the present invention comprise providing or forming an aqueous mixture of the compositions of the present invention and applying them to an area of land sought to be provided with soil erosion and/or fire resistant properties.

Abstract: Compositions and methods for concomitantly resisting fire and soil erosion. The compositions comprise an aqueous mixture of a polymer mixed with an organic material. The polymer preferably comprises polyacrylamide or a copolymer of polyacrylamide having anionic functional groups. The organic material comprises either cellulose, mulch and/or seed and mulch. The methods of the present invention comprise providing or forming an aqueous mixture of the compositions of the present invention and applying them to an area of land sought to be provided with soil erosion and/or fire resistant properties.

Abstract: A method for predicting the contribution of silicon interstitials to n-type dopant transient enhanced diffusion during a pn junction formation is disclosed. Initially, fundamental data for a set of microscopic processes that can occur during one or more material processing operations are obtained. The fundamental data are then utilized to build kinetic models for a set of reactions that contribute substantially to an evolution of n-type dopant concentration and electrical activities. The kinetic models are subsequently applied to a simulator to predict temporal and spatial evolutions of concentration and electrical activity profiles of the n-type dopants.