Abstract: The present disclosure is directed in part to dosing regimens for administering a humanized anti-B7-H3 antibody conjugated to a duocarmycin moiety (a “B7-H3-ADC”) for the treatment of cancer, particularly a cancer associated with expression of B17-H3. The disclosure in part concerns the use of such B7-H3-ADC in combination with a bispecific molecule capable of binding to PD-1 and CTLA-4 (“PD-1×CTLA-4 bispecific molecule”). The disclosure in pant concerns the use of such B7-H3-ADC in combination with lorigerlimab for the treatment of cancer. The disclosure in part concerns the use of MGC018 in combination with lorigerlimab for the treatment of cancer. The disclosure is directed in part to the use of such molecules, and to the use of pharmaceutical compositions and pharmaceutical kits that contain such molecules and that facilitate the use of such dosing regimens in the treatment of cancer.

Abstract: A system uses a hybrid key-value storage engine that uses log-structured merge tree and a segmented log-structured object store. The system performs garbage collection of stale document versions avoiding index lookup during log segment compaction. The system separates index and document data to minimize write amplification. The system maintains a delete list using a log-structured merge-tree to store stale document sequence numbers and corresponding sizes per log segment. For each log segment from the plurality of log segments, the system determines a measure of fragmentation of the log segment based on sizes of deleted documents of the log segment from the second log-structured merge-tree. If the fragmentation exceeds a threshold, the system initiates a compaction operation for the log segment.

Abstract: Disclosed herein are systems and methods for optimizing air traffic control managing using a Quantum Annealing-based iterative path planning technique and algorithm that involves both classical and quantum computation components. The classical component can calculate the distances between aircraft and the target destination from a set of new, possible properties, such as aircraft location. The quantum component can select from the new, possible properties to minimize the distance of the aircraft to the target destination while ensuring adequate separation between aircraft. The algorithm can utilize qubits to represent maneuverability options for aircraft. The maneuverability options may be partitioned into a set of multiple qubits per aircraft. Each set may include a plurality of qubits that are representative of the sub options. The algorithm can utilize Quadratic Unconstrained Boolean Optimization (QUBO) to find the lowest cost-energy maneuverability option.

Abstract: Methods, systems, and apparatuses for storing operational information related to operation of a non-volatile array are described. For example, the operational information may be stored in a in a subarray of a memory array for use in analyzing errors in the operation of memory array. In some examples, an array driver may be located between a command decoder and a memory array. The array driver may receive a signal pattern used to execute an access instruction for accessing non-volatile memory cells of a memory array and may access the first set of non-volatile memory cells according to the signal pattern. The array driver may also store the access instruction (e.g., the binary representation of the access instruction) at a non-volatile subarray of the memory array.

Abstract: Systems and methods for removing carbon from the pyrolysis reactor are disclosed herein. For example, a pyrolysis reactor according to the present technology can include a combustion component that is fluidly couplable to a combustion fuel supply, as well as a reaction chamber that is thermally coupled to an output of the combustion component. Further, the pyrolysis reactor can include a carbon removal component that is operably coupled to the reaction chamber. The carbon removal component can include an actuator, a rod coupled to the actuator, and a scraper head coupled to the rod and positioned within the reaction chamber. The actuator can drive movement of the rod within the reaction chamber, thereby driving movement of the scraper head. The scraper head can include a plurality of teeth that are positioned to scrape carbon deposits from an interior wall of the reaction chamber.

Abstract: A system for automatically handling components to be assembled onto a product on an assembly line includes a carriage that is movable to and between a first, retracted position spaced from the assembly line, and a second position displaced from the retracted position in a direction toward the assembly line. A manipulator on the carriage supports a component mounting tool configured to receive and support at least one component for assembly to the product. The manipulator may be arranged in a first orientation when the carriage is in the first position, and may be pivoted to a second orientation when the carriage is in the second position, such that a component on the component mounting tool is supported in a pose for processing when the carriage is in the first position, and is supported in a pose for joining to the product when the carriage is in the second position.

Abstract: A tool less method of connecting a welding-type power source with a cart is disclosed. In some examples, the cart may be configured to carry one or more gas bottles (and/or cylinders). In some examples, the power source housing and the cart may connect at interfacing ends and/or walls of the housing and cart. A connector, such as a clip for example, may span the interface to connect the power source housing and the cart. Catches (e.g. slots, holes, crevices, and/or protrusions) may be formed in and/or on the power supply housing and/or cart proximate to the interfacing ends and/or walls. In some examples, the catches may be aligned. In some examples, the cart and/or power source housing may include alignment surfaces to assist with alignment. The connector may engage the aligned catches to connect the welding-type power source and cart together at the interface.

Abstract: A device for measuring conductivity of a fluid. The device including a chamber and at least two electrodes. The chamber includes an inlet, an outlet, an upper surface, and a lower surface that runs separate from the upper surface. The fluid enters the chamber through the inlet and flows out of the chamber through the outlet. Moving along a length of the chamber from the inlet to the outlet or from the outlet to the inlet, a distance between the upper surface and the lower surface changes in at least one dimension of the chamber. The two electrodes are configured to measure electrical voltage in the fluid that enters the chamber through the inlet and flows out of the chamber through the outlet.

Abstract: A method for manufacturing a multi-layered and multi-functional thermoplastic composite structure includes supplying a plurality of reinforcing layers including continuous reinforcing fibers and thermoplastic resin to an intermittent press; and supplying at least one functional layer to the intermittent press adjacent to the plurality of reinforcing layers. The at least one functional layer is selected from a group consisting of an electromagnetic shielding layer and a thermal runaway protection layer. The method includes heating and pressing the plurality of reinforcing layers and the at least one functional layer to form a composite laminate.

Abstract: A multi-layer and multi-functional composite structure includes a structural reinforcing portion configured to provide structural support. The structural reinforcing portion includes reinforcing fibers consolidated in a thermoplastic resin. A protecting portion is arranged on one side of the structural reinforcing portion and configured to provide at least one of thermal blocking and fire resistance. A shielding portion is arranged on an opposite side of the structural reinforcing portion and configured to shield electromagnetic interference (EMI).

Abstract: A battery enclosure for a battery system includes a reinforcing layer including reinforcing fibers, a shielding layer, and a thermal protection layer. At least one of the reinforcing fibers, the shielding layer, and the thermal protection layer is consolidated using a thermoplastic resin into one of a body and a cover of the battery enclosure. The shielding layer is arranged on one side of the one of the body and the cover and the thermal protection layer is arranged on opposite side of the one of the body and the cover.

Abstract: Disclosed herein are systems and methods for path planning for UAVs. A set of UAVs is logically arranged into a plurality of swarms, each having a swarm-leader UAV. A first path planning algorithm is applied to determine navigation instructions to steer the swarm-leader UAVs towards respective destinations for the swarms and to deconflict the swarm-leader UAVs from one another. A set of second path planning algorithms is applied to determine navigation instructions to steer non-swarm-leader UAVs in each swarm toward their respective swarm leaders and to deconflict the UAVs from other UAVs in the swarm. Separate QUBO path planning algorithms may be used for the first path planning algorithm and the set of second path planning algorithms. If merging criteria for combining two swarms are met, a single QUBO may be used to control all non-swarm-leader UAVs in merged swarms.

Abstract: A shingle coating asphalt composition is provided that is produced from a paving grade asphalt. The asphalt composition comprises a paving-grade asphalt that has been modified with one or more polymer additives; and a secondary additive comprising one or more of a viscosity reducing agent, a wax, a salt of a fatty acid ester, and an amide of a fatty acid. The shingle coating asphalt coating composition is used to make a shingle. The shingle includes a substrate, the asphalt, and roofing granules.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: Systems and techniques are provided for processing one or more frames. For example, a process can include obtaining a first plurality of frames associated with a first settings domain from an image capture system, wherein the first plurality of frames is captured prior to obtaining a capture input. The process can include obtaining a reference frame associated with a second settings domain from the image capture system, wherein the reference frame is captured proximate to obtaining the capture input. The process can include obtaining a second plurality of frames associated with the second settings domain from the image capture system, wherein the second plurality of frames is captured after the reference frame. The process can include, based on the reference frame, transforming at least a portion of the first plurality of frames to generate a transformed plurality of frames associated with the second settings domain.

Abstract: A deck extender for a personal watercraft can include a deck member supported in a cantilevered configuration over an edge of the deck of the personal watercraft. The deck extender can include mounting sleeves fixed to an upper deck of a personal watercraft with mounting tabs of the deck member received within the mounting sleeves. The deck member can include mounting mechanisms having a receptacle and a pivoting cleat mounted above the receptacle configured for mounting accessories to the deck member. The deck member can have recessed channel members for mounting accessories.

Abstract: A computing device may determine one or more characteristics of a gaming application executing at one or more processors of the computing device. The computing device may determine a gameplay state of the gaming application executing at the one or more processors based at least in part on the one or more characteristics. The computing device may adjust, based at least in part on the state of the gaming application, a target frame rate of image data outputted by the gaming application for display at a display device. The computing device may output, based at least in part on the adjusted target frame rate, the image data for display at the display device.

Abstract: A system for automatically handling components to be assembled onto a product on an assembly line includes a carriage that is movable to and between a first, retracted position spaced from the assembly line, and a second position displaced from the retracted position in a direction toward the assembly line. A manipulator on the carriage supports a component mounting tool configured to receive and support at least one component for assembly to the product. The manipulator may be arranged in a first orientation when the carriage is in the first position, and may be pivoted to a second orientation when the carriage is in the second position, such that a component on the component mounting tool is supported in a pose for processing when the carriage is in the first position, and is supported in a pose for joining to the product when the carriage is in the second position.

Abstract: Methods, systems, and computer program products are provided that automatically scale an application between private and public cloud computing platforms, while simultaneous enforcing policies ensuring private data is persistently stored on the private cloud computing platform, but not the public cloud computing platform. A traffic manager on the public platform routes traffic to instances of a web app executing on a private platform. A traffic monitor on the private platform monitors performance criteria of the private platform, and reports traffic telemetry to the traffic manager. Based on the traffic telemetry, the traffic manager may instantiate one or more instances of the web app on the public platform to handle traffic. Private data gathered by such instantiated instance(s) is persisted to storage in the private platform, but not in the public platform.