Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: One embodiment provides a method, the method including: detecting, using a content focus system, an attentive state of a user with respect to a display; determining, using the content focus system, the attentive state corresponds to content displayed on the display; and increasing, using the content focus system, a size of the content, wherein the increasing comprises increasing the content to a size that covers other content displayed on the display. Other aspects are described and claimed.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: A Heating, Ventilation, and Air Conditioning (HVAC) system that is configured to receive a refrigerant from a condenser at a fixed expansion device and a variable expansion device. The system is further configured to output a first portion of the refrigerant to a first downstream HVAC component at a fixed flow rate using the fixed expansion device. The system is further configured to apply a first force to a pin of the variable expansion device based on a sensed temperature. The system is further configured to apply a second force to a valve of the variable expansion device via the force applied to the pin and to output a second portion of the refrigerant to a second downstream HVAC component at a variable flow rate based on the second force using the valve of the variable expansion device.

Abstract: Methods, systems, and computer program products are provided that automatically scale an application between private and public cloud computing platforms, while simultaneous enforcing policies ensuring private data is persistently stored on the private cloud computing platform, but not the public cloud computing platform. A traffic manager on the public platform routes traffic to instances of a web app executing on a private platform. A traffic monitor on the private platform monitors performance criteria of the private platform, and reports traffic telemetry to the traffic manager. Based on the traffic telemetry, the traffic manager may instantiate one or more instances of the web app on the public platform to handle traffic. Private data gathered by such instantiated instance(s) is persisted to storage in the private platform, but not in the public platform.

Abstract: A display system for display of an item includes a display case into which the item may be placed, a digital video display system, and a lighting system which may be interactive with the video display system to provide an animated, photo-realistic and dynamic background for items being showcased and/or photographed. In certain embodiments, the display case includes a back wall incorporating an output video screen configured to display custom video content of the user's choosing via the digital video display system, the custom videos providing a backdrop for the item being displayed, wherein the lighting system is configured to change color and/or intensity in sync with the color of the changing images produced on the video output screen.

Abstract: A blow molded container is provided. The container includes a neck having a neck finish and a transverse rim that defines an opening. A closure is provided that is engageable with the neck such that the rim is movable relative to the neck to define one or more vents configured for passage of a gas. In some embodiments, methods of use and manufacturing containers are disclosed.

Abstract: Social network postings, including text, images or other media, may provide valuable information regarding a user of the social network with which the postings may be associated. With the authorization of the user, and upon authentication by the social network, an online marketplace may access the social network postings and extract data therefrom, and market one or more recommended items to the user based on the extracted data, which may include color pallets or texture pallets derived from photographs included in the postings.

Abstract: The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.

Abstract: One embodiment provides a method, the method including: detecting, at an information handling device utilizing a input detection system and while the information handling device is in a low power state, a physical user input at an input mechanism of the information handling device, wherein the detecting comprises detecting a force at the input mechanism; determining, utilizing the input detection system, the physical user input comprises a request to power-on the information handling device; and powering on the information handling device. Other aspects are claimed and described.

Abstract: In an example, a system is disclosed. The system comprises a one-piece mandrel, a fuselage coupled to the one-piece mandrel, and a strongback apparatus positioned on the fuselage. The strongback apparatus comprises an arcuate central body comprising a front end, a rear end, and a plurality of elongated members that connect the front end to the rear end, and actuators mounted to the plurality of elongated members. The actuators are configured to move in a radially outward direction from extended positions to retracted positions and comprise (i) proximal ends mounted to the plurality of elongated members and (ii) distal ends having vacuum suction cups. In the extended positions, the vacuum suction cups engage the fuselage on which the strongback apparatus is positioned. As the actuators moves from the extended positions to the retracted positions, the vacuum suction cups pull the fuselage away from the one-piece mandrel.

Abstract: A bone screw for treating a bone fracture having a detent assembly on a body portion thereof. The detent assembly operative to secure the body from movement relative to a bone nail. The detent assembly includes a detent member, for example, an annular member, movable between a first and second position. Positioning the annular member in the second position operates to secure the body of the bone screw from movement relative to the bone nail.

Abstract: A method for controlling brake pressure during a shift of a vehicle out of park may include determining that a first status condition is met when the vehicle is in park with an electric parking brake applied, determining that a second status condition is met when the vehicle is not moving, responsive to detecting a shift of the vehicle out of park when the first and second status conditions are both met, directing a build-up of brake pressure until a brake pressure target is reached, and holding the brake pressure at the brake pressure target until a release condition is met.

Abstract: In some examples, a computing device can include a processor resource and a non-transitory memory resource storing machine-readable instructions stored thereon that, when executed, cause the processor resource to: activate a silent mode for the computing device when a videoconference is initiated, set a threshold volume and designated frequency range for the computing device, deactivate the silent mode for the computing device when a microphone associated with the computing device receives a sound that exceeds the threshold volume and is within the designated frequency range, send the received sound to other users of the videoconference, and activate the silent mode for the computing device when the computing device stops receiving the sound.

Abstract: A shingle coating asphalt composition is provided that is produced from a paving grade asphalt. The asphalt composition comprises a paving-grade asphalt that has been modified with one or more polymer additives; and a secondary additive comprising one or more of a viscosity reducing agent, a wax, a salt of a fatty acid ester, and an amide of a fatty acid. The shingle coating asphalt coating composition is used to make a shingle. The shingle includes a substrate, the asphalt, and roofing granules.

Abstract: A gas turbine engine is provided. The gas turbine engine includes a compressor section, a combustion section, and a turbine section in a serial flow arrangement; and an air-to-air heat exchanger having an air-to-air heat exchanger potential defined by a product raised to a half power, the product being an effectiveness associated with the air-to-air heat exchanger multiplied by an airflow conductance factor associated with the gas turbine engine, and wherein the air-to-air heat exchanger potential is between 0.028 and 0.067 for a bypass ratio associated with the gas turbine engine between 3 and 10 and the effectiveness being between 0.5 and 0.9 and is between 0.015 and 0.038 for a bypass ratio associated with the gas turbine engine between 10 and 20 and the effectiveness being between 0.3 and 0.9.

Abstract: In general, the subject matter described in this disclosure can be embodied in methods, systems, and program products. A computing device can present a messaging user interface and receive user input of a typed message through interaction with the messaging user interface. The typed message can be sent for distribution to a second user account. The computing device can receive a system-generated response to the typed message that was generated by a searching system based on content of the typed message. The system-generated response to the typed message can be presented in the messaging user interface along with an indication that the system-generated response was generated by the searching system.

Abstract: Methods, systems, apparatus, and computer program products that can automatically answer communication sessions received from trusted callers are disclosed herein. One method includes maintaining, by a processor of an information handling device, a list of trusted callers encoded in a memory and automatically answering a communication session received by the information handling device from a trusted caller in the encoded list of trusted callers without receiving input from a user of the information handling device accepting the communication session on the information handling device. Systems, apparatus, and computer program products that include hardware and/or software that can perform the methods for automatically answering communication sessions received from trusted callers are also disclosed herein.

Abstract: Methods, systems, and devices for sensing a memory with shared sense components are described. A device may activate a word line and a plate line each coupled with a set of memory cells, where each memory cell of the set of memory cells is coupled with a respective digit line of a set of digit lines. The device may activate a set of switching components to couple each digit line of the set of digit lines with a respective sense component of a set of sense components, where each switching component of the set of switching components is coupled with a respective memory cell of the set of memory cells. The device may sense the set of memory cells based on activating the word line and the plate line and based on coupling the set of digit lines with the set of sense components.

Abstract: An apparatus a multiple layer structure having a sub-portion defining an impact zone, and having an inner composite fiber layer, an outer composite fiber layer overlying the inner composite fiber layer, and a woven glass layer, where the inner composite fiber layer, outer composite fiber layer, and the woven glass layer overly the impact zone.