Abstract: The present disclosure provides methods of determining whether or not to administer a subject gabapentin, said method comprising assessing the genetic profile of a subject considered for a gabapentin-based therapy and determining, on the basis of the genetic profile, whether or not to administer the subject gabapentin.

Abstract: The disclosure relates to a combination of biomarkers comprising at least: (i-a) one biomarker selected in each of the following group of biomarkers: Patient's age, Plasma steroids, and Urinary steroids, and at least one biomarker selected in at least one of the group of biomarkers: O-methylated catecholamines, Small metabolites, and miRNA; or (i-b) one biomarker selected in each of the following group of biomarkers: Plasma steroids, Urinary steroids, and Small metabolites, and at least one biomarker selected in at least one of the group of biomarkers: Patient's age, O-methylated catecholamines, and miRNA. The combinations of biomarkers may be used for stratifying a hypertensive patient among different hypertensive diseases comprising Endocrine Hypertension (EHT), Primary Aldosteronism (PA), Pheochromocytoma/Functional Paraganglioma (PPGL), Cushing's Syndrome (CS), and Primary Hypertension (PHT).

Abstract: Some embodiments relate to a computer implemented method for managing requests too register subscription devices for service with one or more cellular networks is provided. The method involves storing data representing a plurality of registration record, each being indicative of a respective subscription device being registered for service with a respective cellular network using a respective IMSI. A request to register a subscription device for service is received, the request including at least an IMSI and being associated with one or more request characteristics. An outcome for the request is generated based on whether the plurality of registration records are indicative of another subscription device being registered for service, and if so, at least one of the one or more request characteristics. A computer system for performing the method, and a non-transitory computer readable storage medium are also provided.

Abstract: Detailed herein are systems and methods for large volume design, building, and testing, particularly suited for rechargeable batteries intended for long duration energy storage. A specific item, such as a battery cell, may be designed through input and selection of various components and configurations, along with desired test protocols and configurations. A build team is notified of the new item, and confirms material and resources are ready to build the item. A specific channel is reserved or committed for the test. Test data, along with specifics and any errors or conditions encountered from specification through teardown, is tracked.

Abstract: A method for transmitting configuration data for a secure element is provided. The configuration data is generated in a secure element manager and the method comprises, securing the configuration data using a set of Over-The-Air, OTA, keys associated with the secure element, and transmitting the configuration data using a second interface to a second server for transmitting the configuration data over a non-SMS communications channel A communications network corresponding to the method is also provided. A method of receiving configuration data for a secure element at a host device is also provided. The method comprises receiving the configuration data using a data function for receiving configuration data over a non-SMS communications channel, processing the configuration data using a SIM application toolkit, and forwarding the processed configuration data to the secure element. A host device according to the method is also provided.

Abstract: Methods for operating a communications-enabled application, controlling a secure profile via an operating system, and operating a cellular network are provided. Operating a communications-enable application includes detecting a need for data transmission when the mobile device has a communications status which is incompatible with the need and sending a request to activate a secure profile. Controlling the secure profile includes receiving a request from an application to have data session access via a secure profile and activating a data session utilising a secure profile. Operating the cellular network includes receiving a request to establish a cellular network data communications session from a mobile device including the communications-enabled application and establishing a data session with the mobile device using the secure profile. A mobile device and cellular network for performing the methods are also provided.

Abstract: Some embodiments related to a method for a host device to obtain cellular network connectivity which includes performing a first process at a first time, the first process comprising using non-cellular data connectivity to download a profile data structure, the profile data structure comprising a set of two or more International Mobile Subscriber Identities, IMSIs, and authentication data; and performing a second process at a second time, the second time being after the first time, the second process comprising selecting an IMSI from the set of IMSIs; and attempting to register with a cellular network using the selected IMSI and the authentication data to obtain cellular network connectivity.

Abstract: A method is provided which includes receiving location information, performing a selection operation to select an International Mobile Subscriber Identity (IMSI) for obtaining temporary bootstrap connectivity, and attempting to register with a network using the selected IMSI. The selection operation is configured to select one of a first plurality of IMSIs in a first location and one of a second, different, plurality of IMSIs in a second location. Each of the first plurality of IMSIs includes a first predetermined value for at least the first portion of each respective IMSI and each of the second plurality of IMSIs includes a second, different, predetermined value for at least the first portion of each respective IMSI. The selection operation comprises a first and second preconfigured selection characteristic. A network access element, host device, and network node, according to the method, are also described.

Abstract: Systems and methods for item price assignment. A line recommendation engine receives unassigned records from a queue and stores one or more line recommendations for the unassigned item record in a recommendation database. The line recommendation engine can determine a new line should be recommended, and/or which existing lines the unassigned item record could be assigned to. A user interface can display the one or more line recommendations for the unassigned item record to a user and receive an input indicating a selected line identifier for the unassigned item record. A machine learning engine can modify a parameter of the line recommendation engine based on the selected line identifier.

Abstract: The disclosed invention relates to a method for identifying biomarkers for the stratification of hypertensive patients among different hypertension diseases: endocrine forms of hypertension and primary hypertension. The method is a machine-learning based method using one trained classifier on a predefined input dataset to rank several combinations of omics biomarkers (miRNA, steroids, metanephrines, small metabolites) on the basis of the computation of at least one evaluation parameter. A combination of biomarkers is selected to stratify the hypertensive patient among said plurality of hypertension diseases. Also, the disclosed invention relates to a method for stratifying hypertensive patients, such as hypertensive patients with endocrine forms of hypertension (EHT).

Abstract: A dispenser and methods for dispensing a material into a receptacle comprises a dispenser outlet for dispensing material into the receptacle; a support for receiving a receptacle; at least one lateral sensor positioned to laterally sense a receptacle received on the support; an upper sensor positioned to sense a receptacle received on the support from above; and a controller operatively connected to the lateral and upper sensors. The controller is configured to sense the presence of a receptacle received on the support, calculate the volume of the receptacle and/or the volume of material within the receptacle from data received from the lateral and upper sensors, and control the volume of material dispensed from the dispenser outlet into the receptacle based upon the calculated volume of the receptacle and/or the volume of material within the receptacle.

Abstract: Methods for operating a communications-enabled application, controlling a secure profile via an operating system, and operating a cellular network are provided. Operating a communications-enable application includes detecting a need for data transmission when the mobile device has a communications status which is incompatible with the need and sending a request to activate a secure profile. Controlling the secure profile includes receiving a request from an application to have data session access via a secure profile and activating a data session utilising a secure profile. Operating the cellular network includes receiving a request to establish a cellular network data communications session from a mobile device including the communications-enabled application and establishing a data session with the mobile device using the secure profile. A mobile device and cellular network for performing the methods are also provided.

Abstract: A method is provided which includes receiving location information, performing a selection operation to select an International Mobile Subscriber Identity (IMSI) for obtaining temporary bootstrap connectivity, and attempting to register with a network using the selected IMSI. The selection operation is configured to select one of a first plurality of IMSIs in a first location and one of a second, different, plurality of IMSIs in a second location. Each of the first plurality of IMSIs includes a first predetermined value for at least the first portion of each respective IMSI and each of the second plurality of IMSIs includes a second, different, predetermined value for at least the first potion of each respective IMSI. The selection operation comprises a first and second preconfigured selection characteristic. A network access element, host device, and network node, according to the method, are also described.

Abstract: A method for transmitting configuration data for a secure element is provided. The configuration data is generated in a secure element manager and the method comprises, securing the configuration data using a set of Over-The-Air, OTA, keys associated with the secure element, and transmitting the configuration data using a second interface to a second server for transmitting the configuration data over a non-SMS communications channel A communications network corresponding to the method is also provided. A method of receiving configuration data for a secure element at a host device is also provided. The method comprises receiving the configuration data using a data function for receiving configuration data over a non-SMS communications channel, processing the configuration data using a SIM application toolkit, and forwarding the processed configuration data to the secure element. A host device according to the method is also provided.

Abstract: Systems and methods for item price assignment. A line recommendation engine receives unassigned records from a queue and stores one or more line recommendations for the unassigned item record in a recommendation database. The line recommendation engine can determine a new line should be recommended, and/or which existing lines the unassigned item record could be assigned to. A user interface can display the one or more line recommendations for the unassigned item record to a user and receive an input indicating a selected line identifier for the unassigned item record. A machine learning engine can modify a parameter of the line recommendation engine based on the selected line identifier.

Abstract: A vane for a turbine assembly of a turbocharger includes an airfoil that has a pair of flow surfaces disposed between a hub end and a shroud end and a leading edge and a trailing edge where the airfoil further includes a non-zero sweep angle, a non-zero lean angle, a non-zero twist angle or any two or more combinations thereof. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.

Abstract: A vane for a turbine assembly of a turbocharger includes a first airfoil that includes a length between a leading edge and a trailing edge, a second airfoil that includes a length between a leading edge and a trailing edge where the length of the first airfoil optionally differs from the length of the second airfoil, and one or more intra-vane throats defined at least in part by the first airfoil and the second airfoil. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.

Abstract: A vane for a turbine assembly of a turbocharger includes an airfoil that has a pair of flow surfaces disposed between a hub end and a shroud end and a leading edge and a trailing edge where the airfoil further includes a non-zero sweep angle, a non-zero lean angle, a non-zero twist angle or any two or more combinations thereof. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.

Abstract: A vane for a turbine assembly of a turbocharger includes a first airfoil that includes a length between a leading edge and a trailing edge, a second airfoil that includes a length between a leading edge and a trailing edge where the length of the first airfoil optionally differs from the length of the second airfoil, and one or more intra-vane throats defined at least in part by the first airfoil and the second airfoil. Various other examples of devices, assemblies, systems, methods, etc., are also disclosed.