Abstract: The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Abstract: A device for training users in a proper mixing of pharmaceutical components, or for aiding in the mixing, or for performing the mixing, and administration of pharmaceutical components is disclosed. The device comprises a housing for receiving a pharmaceutical delivery device containing the pharmaceutical components. There is also a microcontroller disposed in the housing and a motion/orientation detection device disposed within or on the housing and in communication with the microcontroller. A method for use of the device is also disclosed, along with a substance for use as one of the pharmaceutical components.

Abstract: A system controls a brightness of an augmented reality (AR) eye-mounted device. The system includes an eye-mounted display, a photodetector system, and a controller. The eye-mounted display includes a contact lens and a femtoprojector. The femtoprojector is contained in the contact lens and is configured to project an AR image to a user's retina. The AR image is overlaid on an external scene viewed by the user through the contact lens. The photodetector system detects a brightness level of the external scene. Based on the brightness level of the external scene, the controller adjusts a brightness level of the AR image projected to the user's retina. In some embodiments, the eye-mounted display receives image data defining the AR image and the controller adjusts a bit depth of the image data based on the brightness level of the AR image.

Abstract: The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Abstract: A gear arrangement for a printer includes a rack and a pinion. The rack has a first end, a first tooth at the first end, and a second tooth adjacent the first tooth, with a width of the first tooth being greater than a width of the second tooth, and the pinion has a first tooth, a second tooth adjacent the first tooth, and a web between the first tooth and the second tooth, with the web to prevent engagement of the first tooth of the rack between the first tooth and the second tooth of the pinion.

Abstract: The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Abstract: A display system for an aircraft includes a controller in communication with a display. The controller receives a category associated with a phase of flight of the aircraft. Information related to operation of the aircraft and associated with the received category is displayed on the display.

Abstract: A plurality of wireless transmitters tethered to a plurality of soil moisture probes, each of said probes having first and second elongate conductive materials encapsulated in a non-conductive substrate, coupled to a power source and configured to be placed in the soil to form a capacitor. An irrigation control box is equipped with a receiver and a processor coupled to a plurality of irrigation control valves, each irrigation control valve corresponding to an irrigation zone wherein at least one probe is placed. The processor converts signal data received from the plurality of transmitters into a soil moisture value and (i) opens a control valve corresponding to the zone to which the probe corresponds upon detecting that the soil moisture value in the zone has dropped below a threshold value and (ii) closes the control valve upon detecting that the soil moisture value has raised above a threshold value.

Abstract: A thermometry apparatus includes a distal probe tip having a hollow interior. An insulating support is at least partially disposed within the interior of the distal probe tip. The insulating support is configured to receive at least one of at least one heating element and at least one temperature sensing element. According to one version, the insulating support is a flexible circuit strip configured to receive the at least one heating element(s) to protect the leads from damage and premature breakage.

Abstract: A protective cover for an insertion probe of a medical instrument. The cover contains a flexible tubular body that compliments the probe geometry and a radially disposed flange that surrounds the proximal end of the body. A series of snap-on fasteners removably connect the cover to the instrument. A camming surface is located on the outer face of the flange which coacts with a cam follower that is movably mounted upon the instrument to flex the cover sufficiently to open the fastener and release the cover from the instrument and move the cover axially toward the distal end of the tip.

Abstract: A luminaire (12), such as an external light for an automobile or a wall sconce, includes at least first set of optical features (16B, 16F) and a second set of optical features (16A, 16C, 16E, 16G). The first set of optical features (16B, 16F) is configured for use with an LED bulb (10) emitting a first type of light emission pattern (20), such that the luminaire outputs a particular light emission pattern. The second set of optical features (16A, 16C, 16E, 16G) is configured for use with a bulb (10) emitting a second type of light emission pattern (24), such that the luminaire outputs a different type of light emission pattern. In this way, the same luminaire may output different light emission patterns depending on the emission pattern of the bulb. The luminaire's emission pattern may also be dependent on the color emitted by the bulb. Different bulbs may be used or different LEDs may be energized in a single bulb to generate the emission patterns.

Abstract: Methods, apparatus, and systems for providing information available during the packaging process for a food to be available during the cooking process for the food.

Abstract: A temperature probe includes a handle and a shaft extending from the handle. The shaft includes a distal end, a proximal end, and a tip at the distal end. The temperature probe also includes a capacitance sensor disposed on one of the handle and the shaft, the capacitance sensor configured to measure a change in capacitance when positioned proximate a conductor. The temperature probe further includes a temperature sensor disposed on the shaft, the temperature sensor configured to measure a body cavity temperature of a patient.

Abstract: The present disclosure relates generally to microfluidic devices and methods for fabricating the devices. More particularly, the present disclosure relates to microfluidic devices having encapsulated fluidic tubing and encapsulated electrodes, microfluidic devices having encapsulated fluidic tubing, encapsulated capillary loops and encapsulated electrodes, and methods of fabricating devices having encapsulated fluidic tubing, encapsulated capillary loops and encapsulated electrodes resulting in reduced dead volume interconnects between the fluidic tubing and capillary loops and associated microchannels and aligned fluidic tubing openings, capillary loop openings, electrodes and other device features.

Abstract: In one embodiment, an LED bulb includes a plurality of metal lead frame strips, including at least a first strip, a second strip, and a third strip. First LED dies have their bottom electrodes electrically and thermally connected to a top surface of the first strip. Second LED dies have their bottom electrodes electrically and thermally connected to a top surface of the second strip. The top electrodes of the first LED dies are wire bonded to the second strip, and the top electrodes of the second LED dies are wire bonded to the third strip to connect the first LED dies and second LED dies in series and parallel. The strips are then bent to cause the LED dies to face different directions to obtain a wide emission pattern in a small space. The strips are then enclosed in a thermally conductive bulb having electrical leads.

Abstract: A temperature measurement system includes a temperature probe including a temperature sensor. The system also includes a reader, and a controller in communication with the temperature sensor and the reader. The system further includes a container housing a plurality of probe covers associated with the temperature probe. The container includes an information feature providing information related to the plurality of probe covers. The reader is configured to read the information and direct a signal to the controller indicative of the information.

Abstract: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

Abstract: A flexible film comprising a wavelength converting material is positioned over a light source. The flexible film is conformed to a predetermined shape. In some embodiments, the light source is a light emitting diode mounted on a support substrate. The diode is aligned with an indentation in a mold such that the flexible film is disposed between the support substrate and the mold. Transparent molding material is disposed between the support substrate and the mold. The support substrate and the mold are pressed together to cause the molding material to fill the indentation. The flexible film conforms to the shape of the light source or the mold.