Abstract: The present application provides novel heterocyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful for inhibiting ERK1/2. By administering to a patient in need a therapeutically effective amount of one or more of the compounds of formula (I), wherein X, Y, Z, J, M, and R1 to R8 are defined herein, these compounds are effective in treating conditions associated with dysregulation of the RAS/RAF/MEK/ERK pathway. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer.

Abstract: An awning is provided that extends from an awning casing. The awning forms an arcuate shape by a plurality of panels having a central longitudinal pivot rod for the rotation of at least one lateral support.

Abstract: A lateral arm assembly and method of operation includes first and second articulating arms comprising first and second ends, the first ends of the articulating arms are mounted upon assembly to a support surface at separate lateral locations. The first ends each comprise separate pivoting mounting structures for forming a first pivotal connection with the first and second articulating arms. The lateral arm assembly also comprises a roller tube having spaced lateral ends supporting respective end brackets that provide a second pivotal connection to the second ends of the articulating arms. The roller tube supports a canopy coupled to a roller shaft, wherein one of the end brackets further supports a device that drives the roller shaft for furling and unfurling the canopy.

Abstract: A lateral arm assembly and method of operation includes first and second articulating arms comprising first and second ends, the first ends of the articulating arms are mounted upon assembly to a support surface at separate lateral locations. The first ends each comprise separate pivoting mounting structures for forming a first pivotal connection with the first and second articulating arms. The lateral arm assembly also comprises a roller tube having spaced lateral ends supporting respective end brackets that provide a second pivotal connection to the second ends of the articulating arms. The roller tube supports a canopy coupled to a roller shaft, wherein one of the end brackets further supports a device that drives the roller shaft for furling and unfurling the canopy.

Abstract: A lateral arm assembly and method of operation includes first and second articulating arms comprising first and second ends, the first ends of the articulating arms are mounted upon assembly to a support surface at separate lateral locations. The first ends each comprise separate pivoting mounting structures for forming a first pivotal connection with the first and second articulating arms. The lateral arm assembly also comprises a roller tube having spaced lateral ends supporting respective end brackets that provide a second pivotal connection to the second ends of the articulating arms. The roller tube supports a canopy coupled to a roller shaft, wherein one of the end brackets further supports a device that drives the roller shaft for furling and unfurling the canopy.

Abstract: A lateral arm assembly and method of operation includes first and second articulating arms comprising first and second ends, the first ends of the articulating arms are mounted upon assembly to a support surface at separate lateral locations. The first ends each comprise separate pivoting mounting structures for forming a first pivotal connection with the first and second articulating arms. The lateral arm assembly also comprises a roller tube having spaced lateral ends supporting respective end brackets that provide a second pivotal connection to the second ends of the articulating arms. The roller tube supports a canopy coupled to a roller shaft, wherein one of the end brackets further supports a device that drives the roller shaft for furling and unfurling the canopy.

Abstract: A lateral arm assembly and method of operation includes first and second articulating arms comprising first and second ends, the first ends of the articulating arms are mounted upon assembly to a support surface at separate lateral locations. The first ends each comprise separate pivoting mounting structures for forming a first pivotal connection with the first and second articulating arms. The lateral arm assembly also comprises a roller tube having spaced lateral ends supporting respective end brackets that provide a second pivotal connection to the second ends of the articulating arms. The roller tube supports a canopy coupled to a roller shaft, wherein one of the end brackets further supports a device that drives the roller shaft for furling and unfurling the canopy.

Abstract: A lateral arm assembly and method of operation includes first and second articulating arms comprising first and second ends, the first ends of the articulating arms are mounted upon assembly to a support surface at separate lateral locations. The first ends each comprise separate pivoting mounting structures for forming a first pivotal connection with the first and second articulating arms. The lateral arm assembly also comprises a roller tube having spaced lateral ends supporting respective end brackets that provide a second pivotal connection to the second ends of the articulating arms. The roller tube supports a canopy coupled to a roller shaft, wherein one of the end brackets further supports a device that drives the roller shaft for furling and unfurling the canopy.

Abstract: A lateral arm assembly and method of operation includes first and second articulating arms comprising first and second ends, the first ends of the articulating arms are mounted upon assembly to a support surface at separate lateral locations. The first ends each comprise separate pivoting mounting structures for forming a first pivotal connection with the first and second articulating arms. The lateral arm assembly also comprises a roller tube having spaced lateral ends supporting respective end brackets that provide a second pivotal connection to the second ends of the articulating arms. The roller tube supports a canopy coupled to a roller shaft, wherein one of the end brackets further supports a device that drives the roller shaft for furling and unfurling the canopy.

Abstract: A retractable motor-driven awning can be extended or retracted by energizing the motor in one direction or another. A manually operable system, however, is also employed for rotating the awning by hand in a direction to retract the awning in the event the motor drive becomes inoperable. The ability to hand rotate the roll bar to retract the awning is achieved by connecting the roll bar to the drive shaft of the motor with a manual override system. Implementations of a manual override mechanism include one-way bearings and various ratchet designs.

Abstract: A canopy for use with a retractable, roll-up awning has lateral sides that taper in width from a wider stationary edge to a slightly narrower leading edge. The lateral edges of the canopy may be hemmed and the taper may be designed such that sections of the hems along each edge corresponding in length to a circumference of a roller tube roll up on the roller tube immediately adjacent but laterally further outward from a prior section of hem wrapped around the circumference of the roller tube during the prior rotation of the roller tube. The hems may house wires in a linear pocket defined therein. The wires connect with the roller tube to provide power or control signals.

Abstract: A retractable motor-driven awning can be extended or retracted by energizing the motor in one direction or another. A manually operable system, however, is also employed for rotating the awning by hand in a direction to retract the awning in the event the motor drive becomes inoperable. The ability to hand rotate the roll bar to retract the awning is achieved by connecting the roll bar to the drive shaft of the motor with a manual override system. Implementations of a manual override mechanism include one-way bearings and various ratchet designs.

Abstract: A retractable awning having one edge of an awning canopy fixed and a movable opposite edge with the opposite edge being secured to a rotatable roll bar includes a floating mounting for the roll bar so that a bias on the roll bar urging the roll bar to rotate toward a retracted position of the awning permits the wrapped fabric on the roll bar to remain in engagement with an engagement wall of a mounting chassis so that the roll bar is prevented from sagging along its length regardless of the number of wraps of fabric about the roll bar.

Abstract: A retractable awning includes a roller reversibly driven and mounted within a housing for support on a support structure and both inner and outer sets of pivotally interconnected support arms for supporting an awning canopy when extended. The inner set of support arms support the canopy beneath an inner segment of the canopy adjacent the support surface and are designed to deploy before the outer set of support arms with the outer set of support arms supporting the canopy beneath an outer segment of the canopy further away from the support surface than the inner segment. Both the inner and outer sets of support arms can be partially or fully deployed to regulate the extent to which the awning is extendible away from the support surface.

Abstract: A connection system for a retractable awning for connecting the canopy of the awning to a support surface includes a rigid or semi-rigid cover and may or may not include a flexible strip of material secured thereto such that when the awning is fully retracted, the rigid or semi-rigid cover extends around a substantial portion of the awning canopy wrapped on a roll bar for the awning to protect the canopy from environmental elements.

Abstract: A process for coloring high-volumes of sand, stone, and other particulate material by continuously feeding the non-colored particulate material, one or more colorants, and an adhesive binder into a mixer and continuously mixing these materials. During the mixing process, colored particulate material is continuously being removed and transported away from the process as a colored end product.

Abstract: A retractable awning combined with an expandable camping trailer includes telescoping support arms and rafter arms that support a roll bar and an awning sheet secured thereto. The support arms and rafter arms automatically extend when the trailer is expanded from a collapsed position and are further extendable into a deployed use position and locked in this position by appropriately manipulating the support and rafter arms and securing them in extended positions with lock mechanisms. The support and rafter arms are conditioned for retraction by releasing the lock mechanisms and positioning the awning adjacent to the side of the trailer such that when the trailer is collapsed by dropping the top of the trailer downwardly toward the bottom of the trailer, the support and rafter arms automatically collapse into nested relationships.

Abstract: A retractable curtain system is mounted in the roof of a recreational vehicle and adapted to be extended downwardly across the width of the vehicle between a driver compartment and the remaining compartments of the vehicle, which are rearwardly of the driver compartment. The curtain is in the form of a pair of side-by-side barrier sheets that move up and down in unison while being wrapped around operatively connected roll bars, but define a slit or gap therebetween through which individuals can pass through the curtain even when it is extended.

Abstract: A deck system for the top of a recreational vehicle or the like includes a platform supported by a base framework that is removably attached to the top of the vehicle. Side and end rails along the periphery of the platform are foldable into adjacent overlying relationship with the platform. A retractable awning is further provided for selectively overlying the platform and a collapsible ladder extends to the platform providing easy access.

Abstract: An awning sheet manual extension system includes a pull strap having a length and longitudinally spaced pockets. The strap includes two ends with one end being adapted for connection to a roll bar of an awning incorporating the pull strap. The system also includes a shaped pull rod having two end segments and at least one intermediate handle portion. At least one of the end segments of the rod is adapted for releasable connection with a free end of the strap. The pull strap is connected to the roll bar such that when the pull strap is pulled by the pull rod, the roll bar is causing to rotate thereby causing the awning sheet to unroll from the roll bar.