Abstract: Systems and methods for interventional dosing based on sensed feedback are disclosed. A system may include one or more reservoirs filled or fillable with, respectively, one or more drug products, an administration member, a fluid delivery system, one or more sensors, and optionally a controller. The administration member may be insertable into a patient and connected or connectable in fluid communication with the one or more reservoirs. The fluid delivery system may be operable to deliver the one or more drug products from the one or more reservoirs to the patient via the administration member. The one or more sensors may be operable to sense one or more biological conditions of the patient, including, but not limited to, a cytokine level and/or a biomarker indicative of cytokine release syndrome. The controller may be configured to control operation of the fluid delivery system based on output from the one or more sensors.

Abstract: A Liquid Crystal Waveguide (LCW) system can provide sub-aperture incoupling or outcoupling of light having an input wavelength and input beamsize defining an aperture characteristic of the system. A Liquid Crystal Waveguide (LCW) can include a generally planar LCW core to receive light via a light input zone for communication toward a light output zone. Sub-aperture interfacial light couplers can be planarly arranged in or parallel to the planar LCW core in the light input zone or the light output zone. Sub-aperture interfacial light couplers can include teeth, prisms, or facets, a photonic crystal metasurface, or a geometric-phased holograph (GPH)). Overall LCW thickness can be reduced, which can be helpful in space-limited applications or for reducing material costs.

Abstract: A drug delivery device includes a housing defining a shell comprising a front portion and a rear portion slidably coupled to the front portion, a drug delivery assembly at least partially disposed within the housing, at least one electronic component, a power source which powers the electronic component, and a switch assembly. The switch assembly is adapted to selectively cause the power source to provide power to the at least one electronic component.

Abstract: A winglet for attachment to a wing portion of an aircraft is disclosed having a winglet tip and a winglet root opposite from the winglet tip. The winglet has an opening for receiving therethrough a connector for connecting the winglet to a wing portion in use. The winglet has a retainer internal of the winglet for use in retaining the connector relative to the winglet. The retainer has a hole that extends along an axis that passes through the opening for receiving therethrough a portion of the connector when the connector is located through the opening. The retainer includes a body for reacting against a retention component with which the connector engages in use.

Abstract: A winglet for attachment to a wing portion of an aircraft is disclosed having a winglet tip and a winglet root opposite from the winglet tip. The winglet has an opening for receiving therethrough a connector for connecting the winglet to a wing portion in use. The winglet has a retainer internal of the winglet for use in retaining the connector relative to the winglet. The retainer has a hole that extends along an axis that passes through the opening for receiving therethrough a portion of the connector when the connector is located through the opening. The retainer includes a body for reacting against a retention component with which the connector engages in use.

Abstract: The INTERIOR COMFORT HVAC USER-FEEDBACK CONTROL SYSTEM AND APPARATUS transforms qualitative feedback received from a user/occupant into a “comfort map,” or modifications thereto, a comfort map being defined at least in part by one or more comfort event windows. The comfort map data is used to determine a temperature setpoint sequence that avoids regions of the map corresponding to known and/or predicted regions of user discomfort.

Abstract: A processor-implemented method of controlling an HVAC system transforms a comfort map into a plurality of sequential constant-temperature segments that are used in generating a control temperature sequence that preserves occupant comfort while improving energy efficiency. The method balances user comfort, temperature trajectory execution complexity, operational HVAC trajectory realization, and energy efficiency. The system achieves this balance through utilization of comfort map metric data, analysis and control system execution. The system, comfort map metric data processing and analysis facilitates this balance by executing a control temperature sequence/temperature trajectories developed based on direct user comfort feedback data within the context of a comfort map and thermal equilibrium boundaries derived from the comfort map.

Abstract: Among other things, a central server maintains information representative of requests communicated through the Internet from devices at request locations. Each of the requests represents a proposed reservation for services to be managed by devices at delivery locations.

Abstract: Techniques for document analysis using machine learning are provided. A selection of an index is received document, and a plurality of documents that refer to the index document is identified. For each respective document in the plurality of documents, a respective portion of the respective document is extracted, where the respective portion refers to the index document, and a respective vector representation is generated for the respective portion. A plurality of groupings is generated for the plurality of documents based on how each of the plurality of documents relate to the index document, by processing the vector representations using a trained classifier. Finally, at least an indication of the plurality of groupings is provided, along with the index document.

Abstract: Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a magnetic actuator operably coupled to a primary container assembly including a drug delivery member. Power can be selectively provided to the magnetic actuator by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the drug delivery member retraction based on the tissue resistive pressure.

Abstract: A disclosed apparatus may include a line source configured to produce a line of light and a scanning device configured to scan the line of light across a scanning field in a scanning direction. The scanning field may include a receiving portion configured to receive an eye. The apparatus may also include a reflector positioned within the scanning field. During a primary period of a scan, the line of light may scan the receiving portion in a primary direction. During a secondary period of the scan, the reflector may reflect the line of light such that a reflection of the line of light scans the receiving portion in a secondary direction. The apparatus may also include a photodetector positioned to receive (1) an initial reflection during the primary period, and (2) a subsequent reflection during the secondary period. Various other methods, apparatuses, and computer-readable media are also disclosed.

Abstract: An optical system for receiving light scanned from different light origination locations in space can include a Liquid Crystal (LC) waveguide (LCW), including first and second LCW light ports. A beamsteering LC electrode can be included in or coupled to the LCW and can be configured to vary a receiving direction of light received at the second LCW light port in response to a varying electrical input signal applied to the LC electrode to scan receiving of light at the second LCW light port from different light origination locations in space. A photodetector can be optically coupled to the first LCW light port, such as to detect waveguided light from different light origination locations in space received in response to the varying electrical input signal applied to the first LC electrode. Ranger, bright-spot locking, laser detection, direct detect and coherent lidar, wavelength detection, and other techniques and use cases are possible.

Abstract: The disclosed eye-tracking systems may include a visible light display having visible light pixels, at least one infrared pixel positioned within bounds of the visible light display, and an infrared sensor positioned and configured to detect infrared light originating from the at least one infrared pixel and reflected from an eye of the user. Related head-mounted display systems and methods for eye tracking are also disclosed.

Abstract: A personal care appliance 10 comprises an actuator 14, a current sensor 28 for monitoring a driving current, and a controller 24. The actuator 14, operable according to a non-linear response characteristic 58 of amplitude versus frequency, includes a movable shaft 18 configured for resonant movement 38 in response to a drive signal 25, further for being coupled with a workpiece 20. The controller 24 (i) detects at least one of a plurality of different characteristic load states (100,102,104,106,108,110) in response to a perturbation in the monitored driving current 29 and (ii) actively delivers the drive signal 25 to the actuator 14 selected from at least two different drive signals (66,70) as a function of a detected characteristic load state.

Abstract: Modular fluid path assemblies are provided that include conduit, coupling, and needle portions of a fluid path fluidly coupled to an outlet of a container. The modular fluid path assemblies further include a needle shield having a tip of the needle embedded therein. So configured, in embodiments, the modular fluid path assemblies can be sterilized, a medicament can be filled in the container, and a stopper inserted in the container so that the pre-sterilized and pre-filled modular fluid path assemblies can have a closed container integrity (CCI) seal.

Abstract: Drug delivery devices are described that include an escapement activation assembly. The escapement activation assembly includes a slide having a plurality of pallet engagement portions and a switch engagement portion and a pallet having a plurality of slide engagement portions. A drive is coupled to the pallet to cause the pallet to move relative to the slide to move the plurality of slide engagement portions into and out of engagement with the plurality of pallet engagement portions to allow the slide to move along a path within the drug delivery device. Movement of the slide can cause the switch engagement portion to move out of engagement with an activation trigger of a mechanism of the drug delivery device.

Abstract: A mooring device including: a strut with a first end and a second end; a first head; a pivot mount; a first suction cup; a rotating mount; a second head; a second suction cup; a rod; and a flotation cover sleeve. The pivot mount allows the first head to pivot about a first head axis and therefore to rotate relative to the strut. The rotating mount allows the suction cup to rotate about a second axis relative to the strut. The flotation cover sleeve having a buoyancy sufficient to render the entire apparatus positively buoyant in water.

Abstract: A microelectronic device is formed by dispensing discrete amounts of a mixture of photoresist resin and solvents from droplet-on-demand sites onto a wafer to form a first photoresist sublayer, while the wafer is at a first temperature which allows the photoresist resin to attain less than 10 percent thickness non-uniformity. The wafer moves under the droplet-on-demand sites in a first direction to form the first photoresist sublayer. A portion of the solvents in the first photoresist sublayer is removed. A second photoresist sublayer is formed on the first photoresist sublayer using the droplet-on-demand sites while the wafer is at a second temperature to attain less than 10 percent thickness non-uniformity in the combined first and second photoresist sublayers. The wafer moves under the droplet-on-demand sites in a second direction for the second photoresist sublayer, opposite from the first direction.

Abstract: A method includes measuring a first signal from a set of pyroelectric devices at a first temperature and measuring a second signal from a set of piezoelectric devices at a first acceleration. The method also includes measuring a third signal from the set of pyroelectric devices at a second temperature and measuring a fourth signal from the set of piezoelectric devices at a second acceleration. The method further includes adjusting a piezoelectric calibration using the first, second, third, and fourth signals.

Abstract: In an integrated circuit, a metal-insulator-metal (MIM) diode includes: a first metallization structure level having a first metal layer; a first dielectric layer over the first metal layer; a metal contact or via on the first metal layer and extending through a portion of the first dielectric layer; and a second metallization structure level having a second metal layer; and a second dielectric layer over the second metal layer. The diode has a first electrode on the metal contact or via, a multilayer dielectric structure on the first electrode, and a second electrode between the multilayer dielectric structure and the second metal layer.