Abstract: Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed.

Abstract: A sleeve hydrocarbon trap is provided. In some examples, the sleeve hydrocarbon trap includes a hydrocarbon adsorbing sleeve, the sleeve adapted to be positioned in a sensor bore and the sleeve including one or more hydrocarbon adsorbing layers, and a cage adapted to retain the hydrocarbon adsorbing sleeve in the sensor bore.

Abstract: Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed.

Abstract: Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed.

Abstract: Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed.

Abstract: The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for inhibitory compounds including such antibodies and binding fragments thereof and to methods of therapeutic use thereof.

Abstract: The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for such antibodies and binding fragments thereof and to methods of therapeutic use thereof.

Abstract: A system, method, and computer program product for reporting and recovering from an internal processor error in a multiprocessor system supporting system management mode. In accordance with the method of the present invention one or more replacement agents are allocated such as during system startup within the multiprocessor system. Machine specific error-reporting registers are monitored for one or more active processor agents during system operation. In response to detecting a faulty agent via the monitoring, a system management interrupt (SMI) request is issued to one or both the faulty agent and a selected replacement agent. In response to receiving the SMI request, the operating state of the faulty agent is copied to the selected replacement agent in system management mode. Operating system processing is then resumed using the replacement agent.

Abstract: A sleeve hydrocarbon trap is provided. In some examples, the sleeve hydrocarbon trap includes a hydrocarbon adsorbing sleeve, the sleeve adapted to be positioned in a sensor bore and the sleeve including one or more hydrocarbon adsorbing layers, and a cage adapted to retain the hydrocarbon adsorbing sleeve in the sensor bore.

Abstract: The present invention is directed to antibodies and binding fragments thereof, which bind with high affinity and specificity to human P-selectin glycoprotein ligand 1 (PSGL-1) and which block both selectin and chemokine binding to PSGL-1 expressed on leukocytes, lymphocytes and endothelial cells and thus which inhibit migration and/or rolling of these cells and to methods for screening for such antibodies and binding fragments thereof and to methods of therapeutic use thereof.

Abstract: A system, method, and computer program product for reporting and recovering from an internal processor error in a multiprocessor system supporting system management mode. In accordance with the method of the present invention one or more replacement agents are allocated such as during system startup within the multiprocessor system. Machine specific error-reporting registers are monitored for one or more active processor agents during system operation. In response to detecting a faulty agent via the monitoring, a system management interrupt (SMI) request is issued to one or both the faulty agent and a selected replacement agent. In response to receiving the SMI request, the operating state of the faulty agent is copied to the selected replacement agent in system management mode. Operating system processing is then resumed using the replacement agent.

Abstract: A system, method, and computer program product for reporting and recovering from an internal processor error in a multiprocessor system supporting system management mode. In accordance with the method of the present invention one or more replacement agents are allocated such as during system startup within the multiprocessor system. Machine specific error-reporting registers are monitored for one or more active processor agents during system operation. In response to detecting a faulty agent via the monitoring, a system management interrupt (SMI) request is issued to one or both the faulty agent and a selected replacement agent. In response to receiving the SMI request, the operating state of the faulty agent is copied to the selected replacement agent in system management mode. Operating system processing is then resumed using the replacement agent.

Abstract: A method and system for dynamically replacing a failing processor in a server system configured with IA-32 architecture without requiring hardware changes to the IA-32 architecture or administrative effort. At least one processor of the multiprocessor system (MP) is initially provided as a reserve (or hot-spare) processor that remains in an idle, off, or low-power mode. While in that mode, the OS is prevented from initially utilizing the hot-spare processor. When a processor failure is detected, SMI code running on a good processor instructs the OS to hold off allocating processes to the failing processor. Contemporaneously, the SMI (and OS) activates and completes an initialization of the hot-spare processor to prepare it to begin receiving the held-off processes. Control is then returned to the OS, which updates the “active” processor list and allocates the threads that were running on the failing processor to the hot-spare processor.

Abstract: A data processing network includes a set of servers, at least one switch module to interconnect the servers, and a management module. The management module consults power state information stored in the network following a power transition and restores power to at least some of the servers and switch modules based on the power state information. The power state information prevents the management module from restoring power to servers and switch modules having incompatible communication protocols. In one embodiment, the plurality of servers and the switch modules are hot-swappable modules that are all inserted into a single chassis. In this embodiment, the server modules and at least one switch module share selected resources of the network including system power. The switch modules and servers may employ Ethernet, fiber channel, optical, and serial communication protocols.

Abstract: When a blade and/or interconnect device is inserted into the chassis of a powered or live server the procedure is known as hot-plugging. Before power is applied to the hot-plugged blade and/or interconnect device the fabric type of already installed blades and/or interconnect devices is correlated with fabric types of newly hot-plugged blade and/or interconnect device. Depending upon results of the correlation, power to the hot-plugged blade and/or interconnect device is allowed or denied.

Abstract: A method for co-operative thermal management of a number of independent electronic devices housed within a common enclosure that includes designating a priority number and measuring a temperature for each of the independent electronic devices. Next, for each of the independent electronic devices, the measured temperature is evaluated to determine if it exceeds a threshold value for the independent electronic device. If the measured temperature exceeds a threshold value, a count-down value is initialize to the designated priority number of the independent electronic device. Following which, the count-down value is evaluated to determine if it is equal to zero. If the count-down value is equal to zero, the independent electronic device is powered down. However, if the count-down value is not equal to zero, a specified time interval is allowed to expire before the count-down value is decremented and re-evaluated to determine if it is equal to zero.

Abstract: Genetically engineered cells are provided which can serve as universal donor cells in such applications as reconstruction of vascular linings or the administration of therapeutic agents. The cells include a coding region which provides protection against complement-based lysis, i.e., hyperacute rejection. In addition, the cell's natural genome is changed so that functional proteins encoded by either the class II or both the class I and the class II major histocompatibility complex genes do not appear on the cell's surface. In this way, attack by T-cells is avoided. Optionally, the cells can include a self-destruction mechanism so that they can be removed from the host when no longer needed.

Abstract: In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween.

Abstract: In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween.

Abstract: A data processing network includes a set of servers, at least one switch module to interconnect the servers, and a management module. The management module consults power state information stored in the network following a power transition and restores power to at least some of the servers and switch modules based on the power state information. The power state information prevents the management module from restoring power to servers and switch modules having incompatible communication protocols. In one embodiment, the plurality of servers and the switch modules are hot-swappable modules that are all inserted into a single chassis. In this embodiment, the server modules and at least one switch module share selected resources of the network including system power. The switch modules and servers may employ Ethernet, fibre channel, optical, and serial communication protocols.