Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: An actuator is introduced that utilizes the forces that result from placing a current carrying coil in a magnetic field to rotate a connected object about at least one axis. In some embodiments, the introduced coil actuator includes a coil of conductor coupled to an arm or other type of structural element that extends radially from an axis of rotation. The introduced coil actuator can be utilized to provide motion control in a variety of different applications such as gimbal mechanisms. In some embodiments, the introduced coil actuator can be implemented in a gimbal mechanism for adjusting an orientation of a device such as a camera relative to a connected platform such as the body of an aerial vehicle.

Abstract: A cloud enabled data exchange platform configured to accept sensed information from publishers and allows downloading of sensed information by subscribers. The platform may utilize a blockchain to verify sensed information without sharing private information, act as a transaction ledger, or provide an interface for digital services/interaction with data. Microservices may be offered on the platform to both publishers and subscribers, such as preconfigured smart city solutions or pre-developed artificial intelligence and machine learning solutions. Publishers may control the format in which sensed information is uploaded. Subscribers may control the format in which sensed information is downloaded.

Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: An ember and flame resistant resettable automatic soffit vent includes a tray with ventilation openings formed in its floor. A mesh screen resides on the floor of the tray spanning the ventilation openings. A flat slide resides atop the screen and also has ventilation openings that match those of the tray. The slide has an open position wherein its ventilation openings align with those of the tray to allow airflow through the vent and a closed position wherein its ventilation openings are misaligned with the ventilation openings of the tray to close off airflow through the vent. The vent can be manually moved between its open and closed positions and one or more tension springs and a thermal link assembly cooperate to move the slide to its closed position if the vent is exposed to a high temperature cause by a fire very near a home.

Abstract: A crimping system for crimping fittings on hoses is disclosed and includes an interface and a crimper machine. The crimper machine is configured to analyze collected information based on identified hose and fitting properties; perform a crimping operation based on the collected information and the identified hose and fitting properties; measure crimping characteristics for the crimping operation; generate an alert based on the measured crimping characteristics and the collected information; and provide the alert to the interface.

Abstract: An introduced autonomous aerial vehicle can include multiple cameras for capturing images of a surrounding physical environment that are utilized for motion planning by an autonomous navigation system. In some embodiments, the cameras can be integrated into one or more rotor assemblies that house powered rotors to free up space within the body of the aerial vehicle. In an example embodiment, an aerial vehicle includes multiple upward-facing cameras and multiple downward-facing cameras with overlapping fields of view to enable stereoscopic computer vision in a plurality of directions around the aerial vehicle. Similar camera arrangements can also be implemented in fixed-wing aerial vehicles.

Abstract: The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.

Abstract: The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of GCase proteins, whether in vitro and/or in vivo. Such compositions include delivery of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Parkinson Disease or related condition resulting from a deficiency in the quantity and/or function of GBA gene product or associated with decreased expression or protein levels of GCase protein.

Abstract: A system, method, and computer-readable medium for performing a data center monitoring and management operation. The data center monitoring and management operation includes: generating a request for a client identifier or an access token for access to a target application programming interface (API); obtaining an access policy associated with the target API; determining a least privileged API access permission based upon the access policy associated with the target API; and, using the client identifier or access token to access the target API when the least privileged API access permission allows access to the target API.

Abstract: The disclosure provides compositions and methods for the preparation, manufacture and use of an adeno-associated virus (AAV) particle for the vectorized delivery of an antibody molecule that binds to tau.

Abstract: An unmanned aerial vehicle (UAV) that includes: a chassis; a plurality of arms that extend outwardly from the chassis; a plurality of propeller assemblies that are supported by the plurality of arms; a canopy that is connected to the chassis so as to provide an outer cover for the UAV that is configured to protect internal components thereof; a frame that is supported by the canopy such that the frame is isolated from the chassis; and a plurality of image capture assemblies that are supported by the frame such that the frame separates the plurality of image capture assemblies from the chassis and the canopy so as to inhibit relative movement between the plurality of image capture assemblies during operation of the UAV.

Abstract: An unmanned aerial vehicle (UAV) that includes: a chassis; a plurality of arms that extend outwardly from the chassis; a plurality of propeller assemblies that are supported by the plurality of arms; a canopy that is connected to the chassis so as to provide an outer cover for the UAV that is configured to protect internal components thereof; a frame that is supported by the canopy such that the frame is isolated from the chassis; and a plurality of image capture assemblies that are supported by the frame such that the frame separates the plurality of image capture assemblies from the chassis and the canopy so as to inhibit relative movement between the plurality of image capture assemblies during operation of the UAV.

Abstract: A system, method, and computer-readable medium for performing a data center monitoring and management operation. The data center monitoring and management operation includes: generating a request for a client identifier or an access token for access to a target application programming interface (API); obtaining an access policy associated with the target API; determining a least privileged API access permission based upon the access policy associated with the target API; and, using the client identifier or access token to access the target API when the least privileged API access permission allows access to the target API.

Abstract: The disclosure relates to compositions, formulations, and methods for the preparation, use, and/or formulation of adeno-associated virus capsid protein variants.

Abstract: An introduced autonomous aerial vehicle can include multiple cameras for capturing images of a surrounding physical environment that are utilized for motion planning by an autonomous navigation system. In some embodiments, the cameras can be integrated into one or more rotor assemblies that house powered rotors to free up space within the body of the aerial vehicle. In an example embodiment, an aerial vehicle includes multiple upward-facing cameras and multiple downward-facing cameras with overlapping fields of view to enable stereoscopic computer vision in a plurality of directions around the aerial vehicle. Similar camera arrangements can also be implemented in fixed-wing aerial vehicles.

Abstract: A system can identify an attribute-based access control policy that comprises a pair comprising a permission policy and a condition policy that is associated with performing an operation on a computing resource. The system can identify that the attribute-based access control policy corresponds to a role policy that is associated with the account. The system can determine whether the account and the role policy satisfy the attribute-based access control policy with respect to the operation, wherein the determining comprises evaluating whether the computing resource and a required permission of the permission policy is declared in the role policy, and evaluating whether the account and the role policy satisfy the condition policy evaluates to true based on attributes of the account and attributes of the computing resource. The system can, in response to determining that the account satisfy the permission policy and the condition policy, perform the operation on the computing resource.

Abstract: The technology described herein relates to autonomous aerial vehicle rotor configurations. In some embodiments, the aerial vehicle includes a central body that extends along a longitudinal axis from a forward end to an aft end including a port side opposite a starboard side. Multiple rotor arms each have a proximal end coupled to the central body and a rotor assembly arranged at a distal end to provide propulsion for the aerial vehicle. The rotor assemblies include a first set of rotor assemblies and a second set of rotor assemblies. The first set of rotor assemblies are arranged in a non-inverted configuration on a top side of the aerial vehicle such that each rotor assembly includes an upward-facing rotor. The second set of rotor assemblies are arranged in an inverted configuration on a bottom side of the aerial vehicle such that each rotor assembly includes a downward-facing rotor.

Abstract: An introduced autonomous aerial vehicle can include multiple cameras for capturing images of a surrounding physical environment that are utilized for motion planning by an autonomous navigation system. In some embodiments, the cameras can be integrated into one or more rotor assemblies that house powered rotors to free up space within the body of the aerial vehicle. In an example embodiment, an aerial vehicle includes multiple upward-facing cameras and multiple downward-facing cameras with overlapping fields of view to enable stereoscopic computer vision in a plurality of directions around the aerial vehicle. Similar camera arrangements can also be implemented in fixed-wing aerial vehicles.

Abstract: Methods and systems are provided for user controlled engine revving. In one example, the engine may be revved to a peak speed according to a target revving sequence in response to a user-initiated command. A revving sound may be provided in response to an input device, without demanding manual depression of an accelerator pedal.