Abstract: Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, based upon the appended sugar, into two distinct compound subsets.

Abstract: Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell. Also provided are compounds useful for the treatment of Alexander disease in subjects at risk of or diagnosed with Alexander disease and methods for the identification of such compounds.

Abstract: Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell. Also provided are compounds useful for the treatment of Alexander disease in subjects at risk of or diagnosed with Alexander disease and methods for the identification of such compounds.

Abstract: Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, based upon the appended sugar, into two distinct compound subsets.

Abstract: Provided herein are methods of decreasing glial fibrillary acidic protein (GFAP) levels in a cell. Such methods include administering an effective amount of a GFAP lowering compound to the cell. Also provided are compounds useful for the treatment of Alexander disease in subjects at risk of or diagnosed with Alexander disease and methods for the identification of such compounds.

Abstract: Process controllers, methods, and systems provide for frequency control to account for the effects of periodic disturbances in the feedback signal of closed loop control systems. The frequency components of the feedback signal are determined, including the magnitude and phase of each. Waveforms for each frequency component are generated with substantially the same magnitude and substantially the opposite phase of each frequency component. The waveforms are then summed to produce a compensating waveform that is summed within the output of the control system so that the effects of the periodic disturbances are cancelled from the control system output being provided to the system under control.

Abstract: The Follower Link Assembly acts as a pivot to raise the pit cushion upon ball impact allowing the bowling ball to pass under the pit cushion and to lower the pit cushion at the end of the pinsetter cycle. By design, the pit cushion was an integral part and dependent upon the follower link assembly for it's movement. The forward, rearward, and upward position of the pit cushion was restricted and controlled by the elongated slot design of the follower link assembly. The Pit Cushion Cam & Roller Kit does not restrict the forward position of the pit cushion. The free rotation of the urethane roller controls rearward and upward rotation of the pit cushion. The steel cam is solidly secured to the pit cushion mount. The free rotation of the urethane roller allows pit cushion to raise allowing the bowling ball to enter ball elevator assembly.

Abstract: The Triple P Turnbar (Turnbar) is manufactured of 11 gauge steel sheet stock bent to specified dimensions and mounted to the turnaround pan to help prevent or eliminate improper bowling pin orientation to the cross conveyor for all Brunswick A and A-2 Automatic Pinsetters. The difference between the Tumbar and previous turnaround pan cam designs is the Tumbar has vertical and horizontal designs to contact and “turn” the bowling pin to result in base first delivery to the cross conveyor. Previous turnaround pan cam designs did not guarantee the contact between the bowling pin and turnaround pan cam would result in base first delivery to the cross conveyor.