Abstract: The invention relates to methods of (i) treating a subject for a disease, (ii) amelioration of decline of forced vital capacity in a subject in need thereof, (iii) modulating ?V?6 integrin, ?V?1 integrin, or both ?V?6 integrin and ?V?1 integrin in a subject in need thereof, (iv) increasing the expression of one or more genes in a subject in need thereof, (v) decreasing the expression of one or more genes in a subject in need thereof, and (vi) modulating the activity of at least one gene affecting fibrotic activity in a subject in need thereof, comprising administration of compounds of Formula (A), Formula (I), Formula (II), or (S)-4-((2-methoxyethyl)(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)amino)-2-(quinazolin-4-ylamino)butanoic acid, or a pharmaceutically acceptable salt thereof as described herein; and administering to the subject at least a second drug selected from pirfenidone and nintedanib, or a salt thereof.

Abstract: A portable temperature-controlled container for receiving and housing one or more handheld carriers, each handheld carrier configured to transfer samples to and from a temperature-controlled storage environment, the handheld carrier including a handle and a tray portion, the tray portion configured to be slid into a port of a rack or tower provided in the temperature-controlled storage environment in order to withdraw a sample located in the port, the portable temperature-controlled container including a housing having an opening forming an internal cavity configured to receive one or more handheld carriers, and a lid configured to substantially close the opening, where the housing includes a recess configured to receive the handle of the handheld carrier such that closing of the lid substantially seals the internal cavity when the one or more handheld carriers are placed in the housing.

Abstract: The present disclosure generally relates to providing live video. An example method includes, at a computer system, while in an editing mode for a presentation, receiving, via one or more input devices, a request to insert an object onto a first slide of the presentation, wherein the request includes associating the object with a source for live video; and while in a presentation mode for the presentation, displaying, via a display generation component, the first slide including concurrent display of the object and one or more visual elements, wherein: in accordance with a determination that the object is associated with a camera, the object includes a live video stream from the camera; and in accordance with a determination that the object is associated with a non-camera external device, the object includes a live video stream that mirrors a portion of a display of the non-camera external device.

Abstract: Curable compounds, hydrogels, build materials, and methods of 3D printing are described herein. In some embodiments, a build material for 3D printing described herein comprises one or more compounds having the structure(s) of Formula (I) and/or Formula (II) herein. Such a build material may also comprise an additional acrylate component and water.

Abstract: A power tool comprises an adjustable auxiliary handle assembly that facilities safe use of the tool by the operator while allowing convenient carry and storage of the tool when not in use. The adjustable auxiliary handle assembly comprises an indexing mechanism that includes an angled connector, a slidable latching mechanism and a handle base. The indexing mechanism allows a longitudinal handle to rotate and be locked in a position convenient and comfortable to the operator. The indexing mechanism is adjustable and can be operated with one hand (e.g., one-handed operation). The latching mechanism holds the auxiliary handle position in place while allowing the power tool to be used in high-torque/high load applications.

Abstract: An electric tool is provided with a second switch that is actuated in order for the tool to be used. The second switch is on a second handle that is grasped by the operator with a different hand than the hand that actuates the main trigger switch. Communication between the second switch and the tool occurs with a wireless signal indicating that the second switch has been actuated.

Abstract: A sling bar assembly allows variable positioning of a sling on the sling bar assembly. Some sling bar assemblies include opposing sling bar members that are movable with respect to one another in a lateral direction. Some opposing sling bar members are repositionable between a locked position, in which movement of the sling members with respect to one another is restricted, and an unlocked position. Some sling bar assemblies include multiple sling hooks positioned on a sling bar member. Some sling bar assemblies include a biasing member that permits movement of a sling hook with respect to the sling bar assembly in the lateral direction.

Abstract: A cooling assembly for a power tool includes an air mover configured to be disposed within a housing assembly at a first end of a generally longitudinal enclosure proximate to a handle enclosure. The air mover is configured to direct air into the housing assembly and then generally perpendicularly to a longitudinally extending direction of the generally longitudinal enclosure. The cooling assembly also includes a duct configured to connect to the air mover and be in fluid communication with the air mover to direct air into the handle enclosure. The duct includes an inflow segment defining a first area for receiving the air from the air mover, an outflow segment defining a second area for directing the air from the air mover into the handle enclosure, and a connecting segment connecting the inflow segment to the outflow segment.

Abstract: A three-dimensional (3D) printing system for manufacturing a 3D article includes a resin vessel, a build tray, a movement mechanism, a light engine, a housing, a gas handling system, and a controller. The resin vessel includes a transparent sheet on a lower side. The housing defines two chambers including an upper chamber and a lower chamber. The upper chamber is in fluidic communication with the resin contained by the resin vessel. The lower chamber is in fluid communication with a lower surface of the transparent sheet. The controller is configured to (a) operate the gas handling system to reduce and control a partial pressure of oxygen in the upper and lower chambers, (b) operate the movement mechanism and the light engine to form the 3D article in a layer-by-layer manner.

Abstract: A heating device for volatizing materials contained in an impregnated pad has a housing including a chamber to receive an impregnated pad for heating, a battery contained in the housing, and a heater arrangement. The heater arrangement in one mode includes at least two heaters, a temperature sensor, and a controller, wherein the controller is configured to power the first heater based on a first temperature and then to power the second heater after the first temperature reaches a second temperature. In another mode, the heater arrangement has at least one heater, temperature sensor, and controller, wherein the controller is configured to provide battery power to the at least one heater to volatize materials in the impregnated pad. The housing has at least one opening to allow volatized materials from the impregnated pad to escape from the housing.

Abstract: A portable temperature-controlled container for receiving and housing one or more handheld carriers, each handheld carrier configured to transfer samples to and from a temperature-controlled storage environment, the handheld carrier including a handle and a tray portion, the tray portion configured to be slid into a port of a rack or tower provided in the temperature-controlled storage environment in order to withdraw a sample located in the port, the portable temperature-controlled container including a housing having an opening forming an internal cavity configured to receive one or more handheld carriers, and a lid configured to substantially close the opening, where the housing includes a recess configured to receive the handle of the handheld carrier such that closing of the lid substantially seals the internal cavity when the one or more handheld carriers are placed in the housing.

Abstract: A utility meter includes a consumption measurement unit for generating consumption data, a meter processor, and a RTC for time stamping the consumption data to provide interval meter data during interval meter operation. A memory stores the interval meter data. The meter processor implements/initiates responsive to a power loss that suspends RTC operation, switching from interval to relative time operation where consumption data is stored as relative consumption data together with a relative time as relative meter data. Responsive power restoration and receiving a current time, the meter switches from relative time to interval meter operation. The restoration time is calculated using the current and an elapsed time since the restoration. The time of restoration and current time is used to generate calculated times. The consumption data from relative time operation is time stamped with the calculated times to provide time-corrected relative meter data that is stored to the memory.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for enhancing security of communications between instances of clients and servers while enabling rotation of server certificates (e.g., X.509 certificates). The systems described herein involve updating a client list of server certificates (e.g., a certificate thumbprint) without reconfiguring or re-installing a client and/or server application, starting a new session (e.g., a hypertext transfer protocol secure (HTTPS) session), or deploying new code. The systems described herein may passively or actively update a client list of certificates to enable a client to security verify an identity of a server instance in a non-invasive way that boosts security from man-in-the-middle types of attacks.

Abstract: The invention relates to methods of therapy using compounds of formula (I) and formula (II): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (II) and pharmaceutical compositions thereof are integrin inhibitors that are useful in therapy for a condition, for example, caused by or associated with an infectious agent, shock, pancreatitis, or trauma. The condition can include one or more of pulmonary fibrosis associated with rheumatoid arthritis or progressive familial intrahepatic cholestasis (PFIC).

Abstract: The invention relates to dosage forms for daily administration of compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: The present disclosure relates to systems, methods, and computer-readable media for enhancing security of communications between instances of clients and servers while enabling rotation of server certificates (e.g., X.509 certificates). The systems described herein involve updating a client list of server certificates (e.g., a certificate thumbprint) without reconfiguring or re-installing a client and/or server application, starting a new session (e.g., a hypertext transfer protocol secure (HTTPS) session), or deploying new code. The systems described herein may passively or actively update a client list of certificates to enable a client to security verify an identity of a server instance in a non-invasive way that boosts security from man-in-the-middle types of attacks.

Abstract: A system is provided for transporting, handling and monitoring samples in a temperature-controlled storage environment. The system includes a handheld carrier configured to transfer samples to and from a temperature-controlled storage station and a temperature-controlled container for receiving and housing one or more carriers. The carrier includes an integrated sample identification and temperature sensing capability configured to monitor a thermal history of one or more samples during transport, handling and storage including as the samples are conveyed between the temperature-controlled storage environment and the temperature-controlled container. That is, the carrier is adapted to be held in the hand during use. A carrier for conveying and monitoring samples during transport, handling and storage is also provided.

Abstract: A device for use with a paddle including a telescoping device coupled to a paddle at an end of the paddle and collapsible into the end of the paddle and the telescoping device having a picker on a first end of the telescoping device wherein the picker is configured to attach to an aperture in a ball.

Abstract: The invention relates to dosage forms for daily administration of compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: A system for manufacturing a three-dimensional article includes a resin vessel, a vertical movement mechanism, and a light engine. The resin vessel includes a lower opening closed by a transparent sheet. The vertical movement mechanism is for positioning a support tray which supports the three-dimensional article. The light engine is disposed below the transparent sheet and is configured to selectively harden layers of resin over a build plane above the transparent sheet. The light engine includes a light bar coupled to a lateral movement mechanism. The light bar includes an array of light emitting devices and a device for impinging upon the transparent sheet. The impingement maintains a proper operating distance H between the transparent sheet and the build plane.