Abstract: A system for manufacturing a three-dimensional article includes a resin vessel, a vertical movement mechanism, and a light engine. The resin vessel includes a lower opening closed by a transparent sheet. The vertical movement mechanism is for positioning a support tray which supports the three-dimensional article. The light engine is disposed below the transparent sheet and is configured to selectively harden layers of resin over a build plane above the transparent sheet. The light engine includes a light bar coupled to a lateral movement mechanism. The light bar includes an array of light emitting devices and a device for impinging upon the transparent sheet. The impingement maintains a proper operating distance H between the transparent sheet and the build plane.

Abstract: A three-dimensional (3D) printing system for manufacturing a 3D article includes a resin vessel, a build tray, a movement mechanism, a light engine, a housing, a gas handling system, and a controller. The resin vessel includes a transparent sheet on a lower side. The housing defines two chambers including an upper chamber and a lower chamber. The upper chamber is in fluidic communication with the resin contained by the resin vessel. The lower chamber is in fluid communication with a lower surface of the transparent sheet. The controller is configured to (a) operate the gas handling system to reduce and control a partial pressure of oxygen in the upper and lower chambers, (b) operate the movement mechanism and the light engine to form the 3D article in a layer-by-layer manner.

Abstract: A device for indicating violation of a temperature limit of an item is provided. The device is positionable near the item and includes a sensor configured to change its state permanently when the temperature limit is violated. The change in sensor state is machine-readable to provide a permanent indication of the temperature limit violation. The sensor includes a reservoir for storing a fluid that changes phase from a solid to a liquid when the temperature limit is violated and a channel in fluid communication with the reservoir for receiving flow of the fluid in liquid phase from the reservoir. The sensor is arranged to allow flow of the fluid in the liquid phase such that the state of the sensor is permanently changed. The sensor is further configured to prevent the fluid flow from permanently changing the sensor state until activation of the sensor from a resting state. A system and method for detecting violation of a temperature limit of an item using the device is also provided.

Abstract: The invention relates to dosage forms for daily administration of compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: An article is configured for transferring tissue cores from a patient donor site to a patient wound site. The article includes a matrix construction of resilient elastomeric polymer material to support an array of tissue core locators individually defining an opening and individually configured to: (1) receive a tissue core from the donor site into the opening, (2) resiliently hold the tissue core at the opening until and after the sheet is placed upon the wound site, and (3) release the tissue core when the sheet is removed from the wound site at a time that is between 2 and 29 days after the sheet is placed upon the wound site.

Abstract: A device for adjustably suspending a pair of gymnastic rings or handles is described. The device has a power spring to automatically retract a pair of straps attached to the rings onto a spool. There is a lock mechanism that holds the pair of straps and rings in place at a desired height. A release cord is attached to the lock mechanism to allow for the release of the lock mechanism from below. A strap retrieval cord may optionally be attached to a strap to allow retrieval of the pair of straps from below.

Abstract: A utility meter includes a consumption measurement unit for generating consumption data, a meter processor, and a RTC for time stamping the consumption data to provide interval meter data during interval meter operation. A memory stores the interval meter data. The meter processor implements/initiates responsive to a power loss that suspends RTC operation, switching from interval to relative time operation where consumption data is stored as relative consumption data together with a relative time as relative meter data. Responsive power restoration and receiving a current time, the meter switches from relative time to interval meter operation. The restoration time is calculated using the current and an elapsed time since the restoration. The time of restoration and current time is used to generate calculated times. The consumption data from relative time operation is time stamped with the calculated times to provide time-corrected relative meter data that is stored to the memory.

Abstract: A cooling assembly for a power tool includes an air mover configured to be disposed within a housing assembly at a first end of a generally longitudinal enclosure proximate to a handle enclosure. The air mover is configured to direct air into the housing assembly and then generally perpendicularly to a longitudinally extending direction of the generally longitudinal enclosure. The cooling assembly also includes a duct configured to connect to the air mover and be in fluid communication with the air mover to direct air into the handle enclosure. The duct includes an inflow segment defining a first area for receiving the air from the air mover, an outflow segment defining a second area for directing the air from the air mover into the handle enclosure, and a connecting segment connecting the inflow segment to the outflow segment.

Abstract: A three-dimensional printing system includes a resin vessel, a build tray, a movement mechanism, a sensor, a light engine, and a controller. The resin vessel is configured to contain photocurable (radiation curable) resin and includes a transparent sheet. The transparent sheet has an upper surface that defines a lower bound for the photocurable resin. The build tray has a lower surface configured to support the 3D article. A lower face is defined by either the build tray or the 3D article. The sensor is configured to output a signal indicative of a vertical position of the transparent sheet. The light engine is configured to image a build plane that is proximate to the upper surface of the transparent sheet. The controller is configured to control motion of the movement mechanism based upon analyzing a signal from the sensor including determining a maximum deflection of the transparent sheet during motion.

Abstract: A system for manufacturing a three-dimensional article includes a resin vessel, a vertical movement mechanism, and a light engine. The resin vessel includes a lower opening closed by a transparent sheet. The vertical movement mechanism is for positioning a support tray which supports the three-dimensional article. The light engine is disposed below the transparent sheet and is configured to selectively harden layers of resin over a build plane above the transparent sheet. The light engine includes a light bar coupled to a lateral movement mechanism. The light bar includes an array of light emitting devices and a device for impinging upon the transparent sheet. The impingement maintains a proper operating distance H between the transparent sheet and the build plane.

Abstract: A system for manufacturing a three-dimensional article includes a resin vessel, a vertical movement mechanism, and a light engine. The resin vessel includes a lower opening closed by a transparent sheet. The vertical movement mechanism is for positioning a support tray which supports the three-dimensional article. The light engine is disposed below the transparent sheet and is configured to selectively harden layers of resin over a build plane above the transparent sheet. The light engine includes a light bar coupled to a lateral movement mechanism. The light bar includes an array of light emitting devices and a device for impinging upon the transparent sheet. The impingement maintains a proper operating distance H between the transparent sheet and the build plane.

Abstract: The present disclosure relates to systems, methods, and computer-readable media for enhancing security of communications between instances of clients and servers while enabling rotation of server certificates (e.g., X.509 certificates). The systems described herein involve updating a client list of server certificates (e.g., a certificate thumbprint) without reconfiguring or re-installing a client and/or server application, starting a new session (e.g., a hypertext transfer protocol secure (HTTPS) session), or deploying new code. The systems described herein may passively or actively update a client list of certificates to enable a client to security verify an identity of a server instance in a non-invasive way that boosts security from man-in-the-middle types of attacks.

Abstract: Disclosed herein are pharmaceutical agents and compositions that activate integrin heterodimers that contain beta-1 integrin protein that specifically bind laminin protein. Such agents and compositions are useful for treating diseases related to muscle malfunction, including muscular dystrophies.

Abstract: A power tool comprises an adjustable auxiliary handle assembly that facilities safe use of the tool by the operator while allowing convenient carry and storage of the tool when not in use. The adjustable auxiliary handle assembly comprises an indexing mechanism that includes an angled connector, a slidable latching mechanism and a handle base. The indexing mechanism allows a longitudinal handle to rotate and be locked in a position convenient and comfortable to the operator. The indexing mechanism is adjustable and can be operated with one hand (e.g., one-handed operation). The latching mechanism holds the auxiliary handle position in place while allowing the power tool to be used in high-torque/high load applications.

Abstract: An electric tool is provided with a second switch that is actuated in order for the tool to be used. The second switch is on a second handle that is grasped by the operator with a different hand than the hand that actuates the main trigger switch. Communication between the second switch and the tool occurs with a wireless signal indicating that the second switch has been actuated.

Abstract: A wearable device is provided for wirelessly reading data in a temperature-controlled environment, the wearable device being adapted to be worn on an upper limb of a user, wherein the wearable device includes an antenna and circuitry adapted to activate the antenna and wirelessly read data from a machine-readable tag in the temperature-controlled environment.

Abstract: The invention relates to dosage forms for daily administration of compounds of formula (A) and formula (I): or a salt thereof, wherein R1, R2, R10, R11, R12, R13, R14, R15, R16, q and p are as described herein. Compounds of formula (A), formula (I), and pharmaceutical compositions thereof are ?v?6 integrin inhibitors that are useful for treating fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: A system for manufacturing a three-dimensional article includes a resin vessel, a vertical movement mechanism, and a light engine. The resin vessel includes a lower opening closed by a transparent sheet. The vertical movement mechanism is for positioning a support tray which supports the three-dimensional article. The light engine is disposed below the transparent sheet and is configured to selectively harden layers of resin over a build plane above the transparent sheet. The light engine includes a light bar coupled to a lateral movement mechanism. The light bar includes an array of light emitting devices and a device for impinging upon the transparent sheet. The impingement maintains a proper operating distance H between the transparent sheet and the build plane.

Abstract: A feeding pouch assembly includes a pouch defining a fluid chamber with an outlet port extending from the pouch. The outlet port is in fluid communication with the fluid chamber. A valve is positioned at the outlet port and is biased to a natural sealing position wherein flow from the fluid chamber to the outlet port is prevented. The valve moves to a non-sealing position, wherein fluid is free to flow from the fluid chamber to the outlet, upon connection of the outlet port to a feeding tube. The valve automatically moves to the sealing position upon disconnection of the feeding tube from the outlet port.

Abstract: There is provided an additive manufacturing system comprising a vertical stage (also known as a z-stage) that moves the object being created along an axis of motion that is not perpendicular to the image plane (non-parallel to the z-axis of the image plane). By moving the build platform, upon which the additively manufactured object is being supported, along a predetermined axis of motion, such as one adapted to the dominant axis of the object design, the additive manufacturing system is capable of making larger objects, shortening build times, improving part resolution, and/or reducing the volume of photocurable material needed, among other benefits.