Abstract: A computing platform is configured to: initialize a three-dimensional (3D) model of a given construction project and thereby determine a first set of objects; cause a first frame of the 3D model to be displayed at an end-user device from a first viewpoint having a first view frustum; receive an indication of a command to display a second frame of the 3D model from a second viewpoint having a second view frustum; identify at least a subset of objects that are contained within the second view frustum; apply one or more object processing techniques and thereby identify one or more additional objects that are contained within the second view frustum; render, as an array of pixels, a second set of objects comprising (i) the subset of objects and (ii) the one or more additional objects; and based on the second set of objects, cause the second frame to be displayed.

Abstract: The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

Abstract: The present disclosure describes ultrasound imaging systems and methods for ultrasonically inspecting biological tissue. An ultrasound imaging system according to the present disclosure may be configured to automatically apply tissue-specific imaging parameter settings (312, 314) based upon the automatic identification of the type of tissue being scanned. Tissue type identification (315) may be performed automatically for the images in the live image stream (304) and thus adjustments to the imaging settings may be applied automatically by using a neural network (320) and thus dynamically during the exam obviating the need for the sonographer to manually switch presets or adjust the imaging settings when moving to different portion of the anatomy.

Abstract: Riveted assemblies are provided that can include a substrate extending between two ends to define opposing substrate surfaces having a first opening extending between the opposing substrate surfaces; a metal-comprising substrate extending between two ends to define opposing metal-comprising substrate surfaces having a second opening extending between the opposing metal-comprising substrate surfaces. The riveted assemblies can further provide that the first and second openings complement one another when the substrate and metal-comprising substrate are engaged; and a rivet shaft extends through the openings and engages the substrate with the rivet head and the metal-comprising substrate with the rivet stop head, at least a portion of the stop head being mixed with, and forming a metallurgical bond with the metal-comprising substrate. Assemblies are provided that can include a rivet stop head mixed with, and metallurgically bonded with a metal-comprising substrate.

Abstract: According to various embodiments, a method, medium, and system for exporting log messages related to a particular job running in a micro services system is described in this disclosure. The method uses a mapping table to narrow down the search scope for finding relevant log files. The mapping table maps a job attribute combination to one or more micro services, and thus will direct the search for relevant log messages only to those log files related to the one or more micro services. The search scope can be further narrowed down using a start time and end time of the job. Once the relevant log files are found, log messages containing an identifier of the job can be extracted from the relevant log files for display or for a user to download. The mapping table can be automatically generated by parsing through historical files in a system non-busy time.

Abstract: The present disclosure relates to antibodies that bind human LAIR1 (“anti-human LAIR1 antibodies” or “anti-human LAIR1 antibodies”), compositions comprising such anti-human LAIR1 antibodies, and methods of using such anti-human LAIR1 antibodies.

Abstract: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.

Abstract: The disclosure relates to binding proteins, including antibodies, that bind to Programmed Death-1 (“PD-1”) and T cell immunoreceptor with Ig and ITIM domains (“TIGIT”). The disclosure also provides compositions comprising such binding proteins and nucleic acid molecules encoding such binding proteins. The disclosure further relates to methods of treating a disorder or condition using such binding proteins.

Abstract: Provided are a computer program product, system, and method for pre-processing a table in a document for natural language processing (NLP). A graphical user interface (GUI) provides a representation of table items in a table in a document including a set of a main element comprising an entity whose value is to be extracted, a conditional element that refines the entity, and a value element comprising a value for the entity. Graphical controls are rendered in the GUI to enable a user to select an element from the table to be the main element, conditional element, and value element. The set of the main element, conditional element, and value element are updated with the user selected element to form a modified set. The modified set of the main element, conditional element, and the value element are provided to an NLP engine to perform natural language processing.

Abstract: Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.

Abstract: Embodiments described herein are generally directed to improvements relating to power, latency, bandwidth and/or performance issues relating to GPU processing/caching. According to one embodiment, a system includes a producer intellectual property (IP) (e.g., a media IP), a compute core (e.g., a GPU or an AI-specific core of the GPU), a streaming buffer logically interposed between the producer IP and the compute core. The producer IP is operable to consume data from memory and output results to the streaming buffer. The compute core is operable to perform AI inference processing based on data consumed from the streaming buffer and output AI inference processing results to the memory.

Abstract: The present invention is an architecture and method for radio frequency (RF) simultaneous transmit and receive applications that uses linear and nonlinear modeling to generate a very accurate, wideband analog signal that cancels self-interference before it is digitized by the receiver. In addition to this digitally assisted analog cancellation, another layer of signal cancellation is provided with digital blind source separation. Adaptive signal processing continuously monitors the level of cancellation and updates the processing to provide optimal performance in changing conditions (e.g., rapidly changing frequency content, signal power, temperature, etc.). Signal cancellation can be performed on extremely broadband signals providing high levels of cancellation, enabling a full-duplex RF transceiver. Furthermore, the present invention optionally includes an external signal canceller for cancelling unknown interference such as jamming.

Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Abstract: Provided herein are engineered hMPV F proteins. In some aspects, the engineered F proteins exhibit enhanced conformational stability and/or antigenicity. Methods are also provided for use of the engineered F proteins as diagnostics, in screening platforms, and/or in vaccine compositions.

Abstract: An opto-electronic device comprising a nucleation inhibiting coating (NIC) disposed on a surface of the device in a first portion of a lateral aspect thereof; and a conductive coating disposed on a surface of the device in a second portion of the lateral aspect thereof; wherein an initial sticking probability of the conductive coating is substantially less for the NIC than for the surface in the first portion, such that the first portion is substantially devoid of the conductive coating; and wherein the NIC comprises a compound having a formula such as that illustrated by the following formula:

Abstract: Devices and methods are provided to overdrive or underdrive a display panel to account for display pixel hysteresis due to several frames of pixel history. An electronic device may include an electronic display and processing circuitry. The electronic display includes a number of display pixels. The processing circuitry may generate image data for the display pixels. The processing circuitry may receive a current frame value of the image data targeted for a first display pixel and, based at least in part on the current frame value and a pixel history of the first display pixel—may indicate a gray level for a number of previous frames—generate a compensated value by which to drive the first pixel to overcome pixel hysteresis to reach the desired luminance at an initial response.

Abstract: Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase: wherein R1 is —NHR1a; R1a is —H or —C(O)CH(R1b)NHR1c; and R1b is selected from —H, —(C1-C4) alkyl and CH2OR1d and R1c is —H; or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring; and R1d is H or —CH3.

Abstract: A component for a vehicle interior may comprise a light guide to allow light transmission from a light source for a user interface, and a cover to cover the light guide. The user interface may be presented at the cover. The cover may comprise a depression in an inner surface of the cover and the light guide may comprise a projection comprising a light-transmissive resin fit within the depression. The projection may comprise an icon to be presented at the user interface when illuminated, and to be hidden by the cover when not illuminated. The user interface may comprise a light display and an input device connected to a sensor. The icon may comprise an image. The cover thickness may be greater than the projection height. The component may comprise a steering wheel, console, floor console, center console, instrument panel, door panel, dashboard, display, armrest, or cockpit.

Abstract: According to an aspect of the disclosure, a glass manufacturing system includes a hot-end subsystem, including: a submerged combustion melter that melts feedstock to produce molten glass; a stiller that receives the molten glass from the submerged combustion melter and that includes a stilling tank to still the molten glass and that is configured to control outflow of the stilled molten glass to effectively decouple viscosity of the molten glass from the flow rate of the molten glass and thereby control finer molten glass levels; and a finer that is mechanically decoupled from the stiller, and that receives and fines the stilled molten glass to produce fined molten glass. Many other aspects of the system are also disclosed and claimed.