Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: The present disclosure generally relates to method and apparatus for preventing coke formation in reactor vapor feed nozzle of a fractionator column of a fluid catalytic cracking unit. One or more baffles are positioned within the fractionator column to prevent effluent vapor that is directed by the reactor vapor feed nozzle into the feed zone from flowing back into the reactor vapor feed nozzle. The reactor vapor feed nozzle itself, or an internal nozzle coupled to the reactor vapor feed nozzle, may extend at least partially into the feed zone to similarly act as a baffle.

Abstract: A resealable closure for a container in which package integrity is indicated by a structure which connects the closure to a remaining portion of the container which must be broken in order to gain access to the contents of the container for a first time. The package integrity feature, in one form, includes a structure associated with the closure, wherein upon opening the closure for a first time, the structure stretches, increasing a length of the structure until the structure eventually breaks, leaving one or both residual ends of the broken structure rippled or curved upward from the remainder of the container. In one alternative form, the structure is associated with a pull tab of the sealing panel, which comprises the closure, whereby either the structure must be broken first, prior to pulling back the sealing panel, or while pulling back the sealing panel for a first time, the structure breaks, prior to gaining access to the contents therein.

Abstract: A system and method for selectively securing data from unauthorized access on a client device storing a plurality of data types with reference to an authorization level indicated in a command. A command is received at a client device comprising an authorization level indicator. Based on at least one predefined rule, which may be implemented in an IT policy stored at the client device, each of the plurality of data types to be secured is determined, and then the data corresponding to those types is secured. The data may be secured by encrypting and/or deleting the data at the client device. The predefined rules associated with each authorization level may be configured by a user or administrator having an authorization level that exceeds the associated authorization level.

Abstract: The invention comprises a package for reactive materials comprising a panel defining a first end, a second end opposite the first end, and at least two side edges. The panel comprises at least one film layer, an adhesive adjacent the film layer, wherein the adhesive is pattern applied such that it is disposed within an interior region of the film layer and wherein a perimeter of the film layer is adhesive-free adjacent each of the first end, second end, and side edges, and a release liner comprising a substrate layer and a cured silicone layer. The release liner is adhered to the film layer via the adhesive, the substrate layer of the release liner is disposed adjacent the film layer, and a perimeter of the release liner is smaller than the perimeter of the film structure. In an embodiment, the panel comprises a tubular body and the side edges are sealed together to form a fin seal, the first end is sealed closed to form an end seal, and the second end is sealed closed to form an end seal.

Abstract: The invention includes a child resistant package having a first panel and at least two second panels joined to the first panel. The first and second panels are in different planes, in an embodiment. The package includes a peelable flap portion covering an access point into the package, wherein the peelable flap portion has at least one tab continuous therewith. The at least one tab is disposed on one of the second panels and the access point is disposed in the first panel. In an embodiment, at least one decoy tab is also disposed on one of the second panels.

Abstract: Disclosed in some examples are methods including selecting a first plurality of single gene mutants from a pool of possible single gene mutants of an organism. The first plurality of single gene mutants is less than a number of possible single mutants. A computer processor is used to iteratively select a second plurality of single gene mutants by selecting single gene mutants from the pool of possible single gene mutants that increases a sum of products of similarities between the first plurality of single gene mutants and corresponding functional relationships. The second plurality of single gene mutants is larger in number than the first plurality of single gene mutants, and wherein the second plurality of single gene mutants is less than the number of possible single gene mutants of the organism. A set of genes is outputted comprising the first and second pluralities of single gene mutants.

Abstract: A method for generating GUIs for condition monitoring is provided and includes maintaining a machine model configuration associating measurement points of a first machine component with first data sources. A generated GUI includes a first portion displaying a list of machines including the first machine and a second machine, and a second portion including visualization of first machine components, including outputs of the first data sources. In response to user selection, the first component visualization is copied from the second GUI portion. The first GUI portion is updated to add the first component as a second component of the second machine. The copied visualization is pasted within the second GUI portion corresponding to the second component. Respective second data sources of the second component measurement points are identified, and the second GUI portion corresponding to the second component can be updated to display the output of the second data sources.

Abstract: A heat exchanger includes a casing configured to direct a working fluid therethrough, and at least one heat exchanger (HE) section in the casing. Each HE section includes a pair of spaced supports. The spaced supports include: an upstream support and a downstream support with at least one of them including a coolant carrying body configured to direct a coolant therethrough. A first cross-support couples to and extends between respective upstream and downstream supports; and at least one second cross-support couples to and extends between the respective upstream and downstream supports. Cross-supports are vertically distanced from adjacent cross-supports. A plurality of tube positioners coupled to each cross-support position a plurality of heat exchange tubes extending across a working fluid path through the casing. The tube positioners and the cooling of the cross-supports allows ferritic material to be used for once-through, duct-fired HRSGs.

Abstract: A computer-implemented method for automatic configuring of a network of interconnected nodes to handle electronic data traffic comprises the steps of receiving a request to transfer a block of data from a source data storage device of the network to a destination data storage device, determining a status for each data storage device and a plurality of data transmission devices, determining paths through the network from the source data storage device to the destination data storage device based upon the status of the devices, sending a prioritized configuration to each subset of data transmission devices to establish the paths from the source data storage device to the destination data storage device, sending a signal to the source data storage device to transfer the block of data to the destination data storage device, and returning the data transmission devices to a default configuration after the block of data has been transferred.

Abstract: A method of fabricating an integrated circuit (IC) includes forming a dielectric layer on a substrate having a plurality of the IC. A thin-film resistor (TFR) layer is deposited on the dielectric layer, and an underlayer (UL) including carbon is formed on the TFR layer. A hard mask layer including silicon is formed on the UL. Masked etching of the hard mask layer transfers a pattern of a photoresist layer onto the hard mask layer to form a hard mask layer pattern. Masked etching of the UL transfers the hard mask layer pattern onto the UL to form a UL pattern. Masked etching of the TFR layer transfers the UL pattern onto the TFR layer to form a TFR layer pattern including a matched pair of TFRs. The matched pair of TFRs are generally included in circuitry configured together for implementing at least one function.

Abstract: A method of manipulating thermoplastic film to create integrated features and particularly relates to an improved method of manufacturing a packaging bag that is reclosable after initial opening. Multiple sections of thermoplastic film are layered on top of themselves to form a multi-layer portion of the thermoplastic film. The multi-layer portion may then be conglomerated into a unitary thicker portion of the film that can then be shaped into a closure strip. In order to form a bag, a second such closure strip may be made. The two closure strips are then aligned and the remaining open portions of the bag are then sealed such that the closure strips form a reclosable opening that may be opened and closed repeatedly.

Abstract: A structure is described for forming a wrapper, e.g., for print media, where the structure includes lines of weakness for facilitating a user's tearing of the wrapper to access the contents. The lines of weakness may include a first line of weakness that extends along a fold line of an envelope fold forming one of the front or rear or right sides of the wrapped package, as well as a second line of weakness that extends substantially perpendicularly to the respective longitudinal fold lines and a third line of weakness that extends between the first line of weakness and the second line of weakness and is disposed at a non-zero angle with respect to each. In this way, a tear initiated near the first line of weakness and may be propagated along the other lines of weakness to create an opening for accessing the product.

Abstract: Systems are provided for the arrangement of decoupled electric and acoustic modules for a transducer array of an ultrasound probe. In one embodiment, the decoupled modules are independently coupled to a flex interconnect, apart from one another, allowing for electric communication between all modules through the flex interconnect. As one example, an ultrasound transducer array for an ultrasound probe comprises an acoustic backing, a flex interconnect coupled to the backing at a first surface of the flex interconnect, a matrix acoustic array coupled to a second surface of the flex interconnect, the second surface opposite the first surface, and an electric module coupled to the second surface of the flex interconnect at a location spaced away from where the matrix acoustic array is coupled to the flex interconnect.

Abstract: The invention comprises a package for reactive materials comprising a panel defining a first end, a second end opposite the first end, and at least two side edges. The panel comprises at least one film layer, an adhesive adjacent the film layer, wherein the adhesive is pattern applied such that it is disposed within an interior region of the film layer and wherein a perimeter of the film layer is adhesive-free adjacent each of the first end, second end, and side edges, and a release liner comprising a substrate layer and a cured silicone layer. The release liner is adhered to the film layer via the adhesive, the substrate layer of the release liner is disposed adjacent the film layer, and a perimeter of the release liner is smaller than the perimeter of the film structure. In an embodiment, the panel comprises a tubular body and the side edges are sealed together to form a fin seal, the first end is sealed closed to form an end seal, and the second end is sealed closed to form an end seal.

Abstract: The present invention relates to novel variants of human BMP7 protein. The invention embodies vectors and host cells for the propagation of nucleic acid sequences encoding said proteins and the production thereof. Also disclosed are methods for the treatment of cancer, cartilage damage and degeneration, pain associated with osteoarthritis, or bone healing.

Abstract: Formation of a sterile connection includes inserting a first aseptic coupling device into a second aseptic coupling device, removing a first membrane from the first aseptic coupling device and a second membrane from the second aseptic coupling device, and rotating a locking clip on the first aseptic coupling device to compress a first seal member of the first aseptic coupling device with a second seal member of the second aseptic coupling device to form a sterile fluid passageway.

Abstract: In some examples, an integrated circuit comprises a substrate; a first metal layer and a second metal layer positioned above the substrate; a first composite dielectric layer located on the first metal layer, wherein the first composite dielectric layer comprises a first anti-reflective coating; a second composite dielectric layer positioned on the second metal layer, wherein the second composite dielectric layer comprises a second anti-reflective coating; and a capacitor metal layer disposed over the first composite dielectric layer.

Abstract: A fiber optic assembly is provided including a body defining a fiber routing volume, a plurality of fiber optic components disposed in a front side of the body, and a plurality of optical filters disposed within the volume. The plurality of optical filters enable at least twenty four (24) dense wavelength division multiplexing (DWDM) channels.

Abstract: A tensioning control device having a first motor that applies a torque to a first end of a substrate in a first direction and a second motor that applies a torque to a second end of the substrate in a second direction that is generally opposite the first direction is disclosed. In this manner, the first motor and the second motor apply torque to the substrate in opposing directions, thereby placing the substrate in tension. In one embodiment, the first motor applies a torque to the first end of the substrate that is equal to the torque applied to the second end of the substrate by the second motor. By placing the substrate in tension in this manner, an actuator is able to incrementally move the substrate in a forward direction and a backward direction independent of the tension applied to the substrate.