Abstract: The present invention relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R1—R16, n and p are defined herein. The novel nitrogen-linked benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth, such as cancer, in patients.

Abstract: A system for automatically handling components to be assembled onto a product on an assembly line includes a carriage that is movable to and between a first, retracted position spaced from the assembly line, and a second position displaced from the retracted position in a direction toward the assembly line. A manipulator on the carriage supports a component mounting tool configured to receive and support at least one component for assembly to the product. The manipulator may be arranged in a first orientation when the carriage is in the first position, and may be pivoted to a second orientation when the carriage is in the second position, such that a component on the component mounting tool is supported in a pose for processing when the carriage is in the first position, and is supported in a pose for joining to the product when the carriage is in the second position.

Abstract: A computer-implemented method conveys information within a virtual environment to a person wearing a virtual reality (VR) headset in a real-world environment. The method includes determining a visual routine for the person to view in the virtual world, the routine comprising a series of images, including triangles, wherein a triangle has a defined perimeter and apex, the visual routine lasting a predetermined time. Presenting, based on the determining, a first triangle to the person in the virtual world; and generating a virtual graphical mark at a prescribed location about the defined perimeter of the first triangle within the virtual world, the virtual graphical mark on the defined perimeter being visible to the person, a relative position of the virtual graphical mark with respect to the apex conveying information relating to an aspect of the visual routine.

Abstract: A torsional damping system includes a housing having an interior space. An inertia ring is located in the interior space, and a torsion fluid is located between the inertia ring and the housing. The inertia ring is rotatably installed relative to the housing. As the housing oscillates, the inertia ring damps at least a portion of the oscillation. The torsional damping system may be included in a downhole tool or bottomhole assembly, and used to damp oscillations along a drill string or along the bottomhole assembly, including between a downhole motor and a cutting tool.

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Abstract: The application relates to a coating composition that combines fouling release and/or ice release performance with flexibility and durability. The coating composition comprises a polyurea component and a polysiloxane component. The polyurea component comprises an isocyanate component, an amine-functional resin and an aliphatic copolymer. The corresponding method for coating a substrate is also addressed.

Abstract: A welding device may include a weld head. A welding device may include a positive welding electrode connected to the weld head. A welding device may include a positive electromagnetic actuator connected to the positive welding electrode. A welding device may include a positive position sensor configured to detect a position of the positive welding electrode. A welding device may include a positive force sensor configured to detect a force applied by the positive welding electrode. A welding device may include a negative welding electrode connected to the weld head. A welding device may include a negative electromagnetic actuator connected to the negative welding electrode. A welding device may include a negative position sensor configured to detect a position of the negative welding electrode. A welding device may include a negative force sensor configured to detect a force applied by the negative welding electrode.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: A smart workstation for manufacturing or repairing an article that requires heat to cure material is disclosed. The smart workstation comprises one or more distribution boxes. Each of the distribution boxes are connected to one or more cure heaters configured to cure an article at a configurable temperature for a configurable time duration. The smart workstation includes one or more programmable control systems configured to control the temperature of the time duration. Parameters of curing, including the temperature and the time duration, can be configured on a human machine interface (HMI) that is connected to the programmable control systems.

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS G12D and/or KRAS G12C inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: Systems and methods are disclosed for tracking, via a blockchain registry, carbon credits in goods produced from materials with sequestered carbon. Materials with sequestered carbon may be produced by reacting greenhouse gases with air and other reagents and catalysts (including biological organisms). Following production of a batch of material with sequestered carbon, a blockchain entry may be recorded with production details and details of carbon-credits earned during production. The carbon-sequestering material may later be converted into products, each of which may have a unique product identifier. A blockchain entry may be recorded with the unique product identifiers such that an owner of a unit of product can obtain, from the blockchain registry, a verified amount of carbon-credit associated with that unit.

Abstract: A system for automatically handling components to be assembled onto a product on an assembly line includes a carriage that is movable to and between a first, retracted position spaced from the assembly line, and a second position displaced from the retracted position in a direction toward the assembly line. A manipulator on the carriage supports a component mounting tool configured to receive and support at least one component for assembly to the product. The manipulator may be arranged in a first orientation when the carriage is in the first position, and may be pivoted to a second orientation when the carriage is in the second position, such that a component on the component mounting tool is supported in a pose for processing when the carriage is in the first position, and is supported in a pose for joining to the product when the carriage is in the second position.

Abstract: The present specification generally relates to a composition for the manufacture of bio-degradable, bio-compostable, ocean degradable, biocompatible articles that contain a bio-based thermoplastic component. In particular, it has been found, in accordance with the practice of this invention, that marked improvement in tensile strength, toughness and elongation of polyhydroxyalkanoate (PHA) can be achieved by dispersing in the PHA an amorphous PHA and then optionally coupling the dispersed amorphous PHA. The polyhydroxyalkanoate/amorphous polyhydroxyalkanoate blends of the present invention comprise from 70-97.5 percent by weight of the PHA, from 2.5-30 percent by weight of the amorphous PHA can be used to produce a wide array of articles.

Abstract: The invention comprises an ovenable packaging structure having an integral one-way valve. The laminate structure comprises an outer layer having a cut line which defines a flap that is separable from the outer layer, wherein the outer layer is adhered to an inner layer having a cut line which is offset from the outer cut line and defines a portion that is separable from the inner layer along the inner cut line and defines an opening into the packaging structure. The adhesive between the layers comprises, in an embodiment, a channel of pressure sensitive adhesive which surrounds both the outer cut line and the inner cut line, wherein the channel of pressure sensitive adhesive defines the perimeter of at least one adhesive-free valve chamber within said channel. The valve chamber comprises at least a portion of the outer cut line and the inner cut line.

Abstract: A system includes an exhaust diffuser system for a heat recovery steam generator (HRSG). The system includes an inlet portion, a diffuser portion axially extending from the inlet portion, and an outlet portion fluidly coupled to an axial distal end of the diffuser portion, wherein an outlet extent of the outlet portion is greater than an inlet extent of the inlet portion. The diffuser portion includes a plurality of wall portions, and the plurality of wall portions is incrementally angled relative to an axial extent extending from the inlet portion to the outlet portion. The system may further include a gas turbine engine coupled to the inlet portion and the HRSG.

Abstract: The present disclosure provides a method of manufacturing an electrode using a continuous coating line for applying an electrode coating layer on a substrate surface of a substrate, the continuous coating line comprising a coating apparatus comprising a coating head and a coating fluid supply system, and at least one oven comprising a heating element, and a substrate carrier for carrying the substrate, the method comprising continuously carrying the substrate through the continuous coating line using the substrate carrier; continuously applying a battery electrode slurry composition from the coating head to the substrate surface to form a wet coated substrate, wherein the battery electrode slurry composition is continuously fed into the coating head by the coating fluid supply system; and heating the wet coated substrate in the oven to form a dried coating on the substrate.

Abstract: A recyclable structure and methods of recycling are provided herein. A recyclable structure for use in packaging comprises a paper layer, and a polymeric film layer. An adhesive layer adhesively joins the paper layer and the polymeric layer. The adhesive layer comprises an acrylic or a urethane adhesive. The recyclable structure 85% by subjecting the structure to mechanical stresses and repulping. The adhesive layer has a greater affinity for the polymeric film layer than the paper layer. Upon repulping the adhesive layer is mostly separated from the fibers within the paper layer.

Abstract: A method for detecting a gene fusion includes amplifying a nucleic acid sample in the presence of primer pool to produce a plurality of amplicons. The primer pool includes primers targeting a plurality of exon-exon junctions of a driver gene. The amplicons correspond to the exon-exon junctions. The amplicons are sequenced and aligned to a reference sequence. The number of reads corresponding to each amplicon is normalized to give a normalized read count. A baseline correction is applied to the normalized read counts for the amplicons to form corrected read counts. A binary segmentation score is calculated for each corrected read count. A predicted breakpoint for the gene fusion is determined based on the amplicon index corresponding to the maximum absolute binary segmentation score. Gene fusion events may be detected in a partner agnostic manner, i.e. without prior knowledge of the specific fusion partner genes or specific breakpoint information.