Abstract: A device and method are described herein relating to a wrist implant guide assembly having a radial guide and a carpal guide. The radial guide may include a radial guide body having a patient-specific surface for matingly contacting a radial bone of a patient, and a radial guide wire aperture configured to direct a guide wire into a radial bone of the patient. The carpal guide may include a carpal guide body having a patient-specific surface for matingly contacting a capitate bone and a hamate bone of the patient, and a carpal guide wire aperture configured to direct a guide wire into a capitate bone of the patient.

Abstract: The present invention provides a Cas9 platform to facilitate single-site nuclease gene editing precision within a human genome. For example, a Cas9 nuclease/DNA-targeting unit (Cas9-DTU) fusion protein precisely delivers a Cas9/sgRNA complex to a specific target site within the genome for subsequent sgRNA-dependent cleavage of an adjacent target sequence. Alternatively, attenuating Cas9 binding using mutations to the a protospacer adjacent motif (PAM) recognition domain makes Cas9 target site recognition dependent on the associated DTU, all while retaining Cas9's sgRNA-mediated DNA cleavage fidelity. Cas9-DTU fusion proteins have improved target site binding precision, greater nuclease activity, and a broader sequence targeting range than standard Cas9 systems. Existing Cas9 or sgRNA variants (e.g., truncated sgRNAs (tru-gRNAs), nickases and FokI fusions) are compatible with these improvements to further reduce off-target cleavage.

Abstract: An intramedullary fixation assembly for bone fixation includes a first construct. The first construct includes a first tapered screw member fixated into a subchondral bone. The first tapered screw member is aligned along a first longitudinal axis and has a first head portion comprising a first aperture and a first shaft extending from the first head portion. Moreover, the first longitudinal axis of the first tapered screw member is aligned substantially parallel to an articular surface of a bone. The first construct also includes a first lag screw member aligned along a second longitudinal axis. The first lag screw member has a first bulbous portion and a second shaft extending from the first bulbous portion, wherein the first lag screw member is coupled to the first tapered screw member, and further wherein the second longitudinal axis of the first lag screw member is aligned generally along the length of the bone.

Abstract: An intramedullary fixation assembly for bone fixation includes a first construct. The first construct includes a first tapered screw member fixated into a subchondral bone. The first tapered screw member is aligned along a first longitudinal axis and has a first head portion comprising a first aperture and a first shaft extending from the first head portion. Moreover, the first longitudinal axis of the first tapered screw member is aligned substantially parallel to an articular surface of a bone. The first construct also includes a first lag screw member aligned along a second longitudinal axis. The first lag screw member has a first bulbous portion and a second shaft extending from the first bulbous portion, wherein the first lag screw member is coupled to the first tapered screw member, and further wherein the second longitudinal axis of the first lag screw member is aligned generally along the length of the bone.

Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.