Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting FLT3 on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.

Abstract: Disclosed herein are MEMS devices and systems and methods of manufacturing or operating the MEMS devices and systems. In some embodiments, the MEMS devices and systems are used in imaging applications.

Abstract: Multi-specific binding proteins that bind NKG2D receptor, CD 16, and FLT3 are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of autoimmune disease or cancer.

Abstract: Compounds useful as linker-payload compounds are disclosed. The compounds have the following Structure (I): as a stereoisomer, enantiomer or tautomer thereof or a mixture thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X1, X2, X3, X4, X5, R4a, and R4b are as defined herein. Additional compounds, conjugates, methods of preparation, pharmaceutical compositions, and methods of treatment related to conjugates of compounds of Structure (I) and a targeting moiety, or binding fragment thereof, are also provided.

Abstract: A system, method, and apparatus for decentralized authentication and sale of a product is provided that, in some embodiments, comprises a distributed ledger, a first computing device associated with at least one real-world product owner, and a second computing device associated with a buyer. The distributed ledger generates and links a digital product identifier to at least one real-world product, wherein the digital product identifier is physically affixed to the at least one real-world product. The first computing device stores at least one owner digital wallet, receive at least one unit of currency, and transfer the digital product identifier. The second computing device stores at least one buyer digital wallet, transfers the at least one unit of currency, and receives the digital product identifier. The distributed ledger also determines one or more spatial parameters and generates and transmits a spatial output responsive to a spatial output request.

Abstract: The invention discloses a semiconductor multi-station processing chamber. Each of the multiple station includes a downward concave accommodation defined by walls and receives a pedestal therein. The pedestal and the walls define a first gap. A showerhead plate mounted on an upper lid above the pedestal to define a processing region. A second gap for supply swiping gas is defined between the showerhead plate and the upper lid. An isolation member is liftable between the downward concave accommodation and the showerhead plate to optionally encircle a processing region defined by the pedestal and the showerhead plate or to retract back into the downward concave accommodation. Such that, when the isolation member surrounds and encircles the processing region, the station is able to be structurally isolated from its neighboring one station.

Abstract: An electronic device is provided, including a substrate, a conductive element, and an insulating layer. The conductive element is disposed on the substrate. The conductive element includes a first layer, a second layer, and a third layer. The second layer is disposed on the first layer. The third layer is disposed on the second layer. The insulating layer is disposed on the conductive element. A thickness of the second layer is greater than a thickness of the first layer, and the thickness of the second layer is greater than a thickness of the third layer. There is a gap between the insulating layer and the conductive element.

Abstract: An electronic device is provided and includes a wiring structure including a conductive wiring and an insulating layer. The conductive wiring is disposed on a substrate and has a top side and two side walls opposite to each other. The insulating layer wraps around the conductive wiring at least through the top side and two side walls, wherein there is a gap between the insulating layer and at least one of the two side walls. The conductive wiring includes a first layer, a second layer and a third layer, the second layer is disposed between the first layer and the third layer, and the first layer is disposed between the second layer and the substrate. A thickness of the second layer is greater than a thickness of the first layer, and the thickness of the second layer is greater than a thickness of the third layer.

Abstract: An electronic device is provided and includes a wiring structure including a conductive wiring and an insulating layer. The conductive wiring is disposed on a substrate and has a top side and two side walls opposite to each other. The insulating layer wraps around the conductive wiring at least through the top side and two side walls, wherein there is a gap between the insulating layer and at least one of the two side walls. The conductive wiring includes a first layer, a second layer and a third layer, the second layer is disposed between the first layer and the third layer, and the first layer is disposed between the second layer and the substrate. A thickness of the second layer is greater than a thickness of the first layer, and the thickness of the second layer is greater than a thickness of the third layer.

Abstract: A wiring structure is provided, including a conductive wiring and an insulating layer. The conductive wiring is disposed on a substrate and has a top side, a bottom side and two side walls opposite to each other. The insulating layer which wraps around the conductive wiring at least through the top side and two side walls, wherein there is a gap between the insulating layer and at least one of the two side walls.

Abstract: A wiring structure is provided, including a conductive wiring and an insulating layer. The conductive wiring is disposed on a substrate and has a top side, a bottom side and two side walls opposite to each other. The insulating layer which wraps around the conductive wiring at least through the top side and two side walls, wherein there is a gap between the insulating layer and at least one of the two side walls.

Abstract: A video management storage system for cloud storage is disclosed. The storage system comprises at least one video camera configured to record video, a recording gateway coupled to the cloud storage and the at least one video camera configured to store the record video in a first folder, wherein the recording gateway includes a video management storage archiver configured to perform a file to many object conversion of the record video from the first folder to a second folder and retains a meta-data object mapping file of the file to many object conversion before transferring the many objects to the cloud storage.

Abstract: Systems, methods, and computer readable media to improve the operation of display systems are disclosed. In general, techniques are disclosed for dynamically adjusting backlight elements based on image content. More particularly, a backlight element's intensity may be targeted for boosting (i.e., increasing) based on content of the backlight element's corresponding image region, where after a check may be made to determine if the proposed increase is likely to risk generation of a halo. If the proposed intensity increase would risk a halo, the backlight element's proposed intensity may be dimmed. Repeating the boost/dim cycle in an iterative fashion permits an image to be displayed with brighter highlights and deeper blacks.