Abstract: In some embodiments, data from multiple vehicle-based natural gas leak detection survey runs are used by computer-implemented machine learning systems to generate a list of natural gas leaks ranked by hazard level. A risk model embodies training data having known hazard levels, and is used to classify newly-discovered leaks. Hazard levels may be expressed by continuous variables, and/or probabilities that a given leak fits within a predefined category of hazard (e.g. Grades 1-3). Each leak is represented by a cluster of leak indications (peaks) originating from a common leak source. Hazard-predictive features may include maximum, minimum, mean, and/or median CH4/amplitude of aggregated leak indications; estimated leak flow rate, determined from an average of leak indications in a cluster; likelihood of leak being natural gas based on other indicator data (e.g. ethane concentration); probability the leak was detected on a given pass; and estimated distance to leak source.

Abstract: The present disclosure relates to an apparatus and method for a load handling system such that direction change of a transporting device is more easily and quickly realised. A transporting device includes an omnidirectional driving unit, and is arranged to transport a container, the container being stored in a facility. The facility is arranged to store the container in a plurality of stacks, a plurality of pathways being arranged in cells so as to form a grid-like structure above the stacks, the transporting device being arranged to operate on the grid-like structure and to be driven in a first direction and/or second direction.

Abstract: The present invention provides a transporting device for a storage system which maximises storage capacity of the storage system whilst remaining scalable and avoiding overheads. The transporting device includes a frame having a Z-direction track and a tray for supporting the container. The tray includes an X-direction movement unit arranged to move the container in an X-direction, a Y-direction movement unit arranged to move the container in a Y-direction and a Z-direction movement unit arranged to move the tray in a Z-direction by way of interaction with the Z-direction track. The transporting device can include a frame having a Z-direction track and a first movement unit arranged to move the container in an X-direction and/or a Z-direction by with the Z-direction track. A second movement unit is arranged to move the container in a Y-direction and/or a Z-direction.

Abstract: The present disclosure generally relates to polynucleotides and AAV vectors that provide for the expression of ALD protein in target (e.g., neurons or glial) cells when administered to subjects in need thereof. The present disclosure further relates to compositions comprising such a polynucleotide or vector. These polynucleotides, vectors, and compositions may be used for the treatment and prevention of ALD or AMN in subjects in need thereof.

Abstract: The present disclosure generally relates to polynucleotides and AAV vectors that provide for the expression of ALD protein in target (e.g., neurons or glial) cells when administered to subjects in need thereof. The present disclosure further relates to compositions comprising such a polynucleotide or vector. These polynucleotides, vectors, and compositions may be used for the treatment and prevention of ALD or AMN in subjects in need thereof.

Abstract: A flow rate control method for solicited data communications includes receiving, at a first node of a communications network, a request-to-send (RTS) signal from a second node of the communications network, the RTS signal indicating a size of a solicited data transmission of the second node, determining, by the first node, whether a rate-limiting counter is above zero, wherein the rate-limiting counter is programmed to increase at a programmed rate and in response to the rate-limiting counter being above zero, scheduling, by the first node, a clear-to-send (CTS) signal to be sent from the first node to the second node over the communications network, and subtracting, by the first node, a value corresponding to the size of the solicited data transmission of the second node from the rate-limiting counter.

Abstract: The present disclosure relates to an apparatus and method for a load handling system such that direction change of a transporting device is more easily and quickly realised. A transporting device includes an omnidirectional driving unit, and is arranged to transport a container, the container being stored in a facility. The facility is arranged to store the container in a plurality of stacks, a plurality of pathways being arranged in cells so as to form a grid-like structure above the stacks, the transporting device being arranged to operate on the grid-like structure and to be driven in a first direction and/or second direction.

Abstract: A form for constructing a foundation for batter’s and catcher’s boxes and supporting a home plate in a support structure of a synthetic turf field for playing baseball or softball includes a hollow frame comprising an open upper surface and an open lower surface, the hollow frame sized to extend under the batter’s and catcher’s boxes, and a home plate frame supportable by the hollow frame, the home plate frame having a cavity for receiving the home plate.

Abstract: Compositions for CDKL5 gene therapy are provided, as well as recombinant CDKL5 proteins. Such CDKL5 gene therapy compositions and/or recombinant CDKL5 proteins may incorporate cell-penetrating polypeptides and/or leader signal polypeptides. Also provided are methods of producing such gene therapy compositions and recombinant CDKL5 proteins, as well as pharmaceutical compositions, methods of treatment, and uses of the gene therapy compositions and recombinant CDKL5 proteins.

Abstract: The present disclosure generally relates to polynucleotides and AAV vectors that provide for the expression of ALD protein in target (e.g., neurons or glial) cells when administered to subjects in need thereof. The present disclosure further relates to compositions comprising such a polynucleotide or vector. These polynucleotides, vectors, and compositions may be used for the treatment and prevention of ALD or AMN in subjects in need thereof.

Abstract: The present disclosure relates to an apparatus and method for a load handling system such that direction change of a transporting device is more easily and quickly realised. A transporting device includes an omnidirectional driving unit, and is arranged to transport a container, the container being stored in a facility. The facility is arranged to store the container in a plurality of stacks, a plurality of pathways being arranged in cells so as to form a grid-like structure above the stacks, the transporting device being arranged to operate on the grid-like structure and to be driven in a first direction and/or second direction.

Abstract: The present disclosure provides an improved cogwheel permitting enhanced meshing of cogwheels when operating perpendicularly. Exemplary embodiments introduce a multi-cogwheel design with specific dimensions and tooth profiles to permit perpendicular engagement of cogwheels whilst permitting translation of such cogwheels.

Abstract: A storage system as disclosed can maximize storage capacity whilst remaining scalable. A transporting device is arranged to form a cluster with a reconfigurable physical topology. A transporting device can cooperate with a portion of a surface, and with at least one other transporting device in a cluster with a reconfigurable physical topology. An item receiving space and a relocating unit permit relocation of the transporting device within the cluster by way of interaction with the portion of the surface.

Abstract: The present disclosure generally relates to polynucleotides and AAV vectors that provide for the expression of ALD protein in target (e.g., neurons or glial) cells when administered to subjects in need thereof. The present disclosure further relates to compositions comprising such a polynucleotide or vector. These polynucleotides, vectors, and compositions may be used for the treatment and prevention of ALD or AMN in subjects in need thereof.

Abstract: There is provided a container maneuvering apparatus arranged to provide an interface between a container-conveying system and a container-storage system. More specifically, there is disclosed a container maneuvering apparatus arranged to load/unload a container into/from a carriage. Optionally, the carriage is a Magway carriage. The carriage can be made stationary before loading/unloading the container by the container-conveying system. The carriage and container can match velocities so that both are moving, but at the same velocity, whilst loading/unloading operations are performed by the container maneuvering apparatus.

Abstract: Disclosed herein are compositions and formulations containing a TAT?-CDKL5 fusion protein. Also disclosed are methods of producing a TAT?-CDKL5 fusion protein from vectors containing a TAT?-CDKL5 cDNA and methods of transducing cells with the vectors containing a TAT?-CDKL5 cDNA and the TAT?-CDKL5 fusion protein. Also disclosed are uses of TAT?-CDKL5 fusion proteins for treating CDKL5 deficiencies by systemic or intravenous administration of the fusion proteins.

Abstract: The present disclosure relates to an apparatus and method for a load handling system such that direction change of a transporting device is more easily and quickly realised. A transporting device includes an omnidirectional driving unit, and is arranged to transport a container, the container being stored in a facility. The facility is arranged to store the container in a plurality of stacks, a plurality of pathways being arranged in cells so as to form a grid-like structure above the stacks, the transporting device being arranged to operate on the grid-like structure and to be driven in a first direction and/or second direction.

Abstract: A storage system as disclosed can maximize storage capacity whilst remaining scalable. A transporting device is arranged to form a cluster with a reconfigurable physical topology. A transporting device can cooperate with a portion of a surface, and with at least one other transporting device in a cluster with a reconfigurable physical topology. An item receiving space and a relocating unit permit relocation of the transporting device within the cluster by way of interaction with the portion of the surface.

Abstract: Novel CDKL5 enzyme variants are provided, as well as fusion proteins comprising full-length CDKL5 polypeptides or CDKL5 variants. Such fusion proteins can include cell-penetrating polypeptides and optionally comprising a leader signal polypeptide and/or tags. Also provided are methods of producing such CDKL5 variants and fusion proteins, as well as pharmaceutical compositions, methods of treatment, and uses of such recombinant proteins.