Abstract: Novel CDKL5 enzyme variants are provided, as well as fusion proteins comprising full-length CDKL5 polypeptides or CDKL5 variants. Such fusion proteins can include cell-penetrating polypeptides and optionally comprising a leader signal polypeptide and/or tags. Also provided are methods of producing such CDKL5 variants and fusion proteins, as well as pharmaceutical compositions, methods of treatment, and uses of such recombinant proteins.

Abstract: Described herein are dosing regimens and kits for the treatment and/or prevention of lysosomal storage disorders such as Gaucher disease. Also described are dosing regimens and kits for the treatment and/or prevention of degenerative disorders of the central nervous system, such as the synucleinopathies Parkinson's disease or Lewy Body Dementia.

Abstract: An intravascular catheter site pad is provided for thermal exchange (e.g. cooling) adjacent to a catheter introduction site (e.g. a catheter for the administration of a chemotherapeutic agent). The pad includes an opening defined by an opening edge that may be positioned about the catheter introduction site. The pad may further include a fluid containing layer and an inlet port and an outlet port for circulating fluid (e.g. cooled fluid) through the pad. The pad may be fluidly interconnected to a fluid conditioning unit to circulate fluid through the pad under negative pressure. The pad, system and an associated method may be employed to reduce tissue damage at an IV catheter introduction site.

Abstract: Described herein are dosing regimens and kits for the treatment and/or prevention of lysosomal storage disorders such as Gaucher disease. Also described are dosing regimens and kits for the treatment and/or prevention of degenerative disorders of the central nervous system, such as the synucleinopathies Parkinson's disease or Lewy Body Dementia.

Abstract: Embodiments include systems and methods for assisting with financial planning. In one embodiment, a financial planning system generates a convenient user interface that displays a variety of financial information in an easy to understand format. In one embodiment, a financial planning system aggregates data from multiple sources and displays the data in a manner that is useful for financial planning, such as debt, retirement, and budget planning. In another embodiment, the financial planning system promotes financial services and products.

Abstract: Child development educational displays are disclosed. The educational apparatus disclosed herein may be mobile and may include one or more three dimensional interactive educational aides demonstrating an aspect of child development to a user. An educational apparatus may be located within the trailer of a truck, or may be located within a tent, or other moveable, structure. The structure may have two or more areas wherein each area contains materials which teach a user about one of a plurality of stages of baby or childhood development.