Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic coronavirus proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.

Abstract: Aspects of this disclosure relate to various systems and methods for use in a regulated industry and using an SEC qualified stablecoin as a store of value and medium of exchange on a blockchain-based transaction network. The system includes a stablecoin blockchain system with a stablecoin blockchain framework, a stablecoin ecosystem, and a stablecoin blockchain transaction network. The stablecoin blockchain system facilitates transactions between stablecoin blockchain participants within the stablecoin ecosystem. The stablecoin ecosystem conducts transactions across a stablecoin blockchain transaction network and a distributed blockchain ledger.

Abstract: According to one aspect, an electric toothbrush may include a handle, a brush head, a rechargeable battery, an electric motor, and a pair of electrical contacts. The handle may have a first end region and a second end region defining a longitudinal axis therebetween, the handle defining a volume from the first end region to the second end region. The brush head may include bristles, the brush head releasably securable to the first end region of the handle. The rechargeable battery may be in the volume. The electric motor may be at least partially disposed in the volume, the electric motor in electrical communication with the rechargeable battery, the electric motor in mechanical communication with the brush head. The pair of electrical contacts may be in electrical communication with the rechargeable battery, and the pair of electrical contacts axially and radially spaced from one another, relative to the longitudinal axis.

Abstract: This invention is a specially designed and shaped liquid storage tank that attaches directly to the lift arms of the skid steer or track loader. The storage tank holds a portion of the weight of the liquid in the storage tank directly over the tank treads or caterpillar tracks of the skid steer thereby greatly improving the stability of the skid steer to allow successful navigation of very rugged terrain even with a full load of liquid in the storage tank. At least thirty percent of the storage capacity of the storage tank is positioned behind the attachment plate or quick attachment plate of the skid steer or track loader. The invention may include a hydraulic water pump which can be used to spray water from the storage tank to fight wildfires. The invention may include a hydraulic power generator. The invention may include a fuel pump.

Abstract: The invention relates to packaged lyophilized agents. In particular, the present invention relates to compact lyophilized agents that are packaged in flexible containers, and systems for their manufacture and use.

Abstract: Methods and systems for electrolyte regeneration are provided, which regenerate a spent alkaline electrolyte (SE) comprising dissolved aluminum hydrates from an aluminum-air battery, by electrolysis, to precipitate aluminum tri-hydroxide (ATH) and form regenerated alkaline electrolyte, and adding a same-cation salt to an anolyte used in the electrolysis to supplant a corresponding electrolyte cation. The regeneration may be carried out continuously and further comprise mixing the SE and the same-cation salt in a salt tank configured to deliver the anolyte, removing the regenerated alkaline electrolyte from a catholyte tank configured to deliver the catholyte, and filtering the ATH from a solution delivered from the salt tank to the anolyte. Optionally, the salt may be a buffering salt, and in some cases chemical reactions may be used to enhance the regeneration by electrolysis.

Abstract: There is disclosed a photography housing (10) for a portable electronic device (56) having an image sensor (58). The housing has first (12) and second (14) housing components defining at least a partial enclosure for receiving a portable electronic device, the first and second housing components being movably connected to one another, such that an internal dimension of the at least partial enclosure can be altered to releasably fit a dimension of the portable electronic device (56) inserted therein. The housing (10) comprises a user input device (22, 24, 26, 28) for controlling the operation of the image sensor (58) during use of the photography housing. The housing may provide a professional photography housing for a mobile telephone, e.g. providing ergonomic shutter control and photographic function selection via wireless communication with the mobile telephone.

Abstract: Disclosed herein are compounds useful for modulating the mu-opioid receptor (“MOR”) and/or delta-opioid receptor (“DOR”), and methods of using these compounds to treat diseases and conditions, such as pain. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.

Abstract: Systems and methods for evaluating structural integrity by predicting failure and corresponding consequences for different components in a respective structure using geospatial data for criteria related to the structure components and multiple weights assigned to each respective criterion. The integrity of the structure is maintained by inspecting, repairing and/or replacing one or more components in the structure based on the predicted structural failure and its corresponding consequence.

Abstract: The present disclosure describes a method to treat conditions, including cancer, using compounds that can target resistant cancer cells. The compounds of the invention can decrease the rate of proliferation of drug-resistant cancer cells, such as glioma, lung cancer, and uterine sarcoma.

Abstract: Systems and methods are described to enable automation of service discovery records, such as domain name system (DNS) records, based on rules. An administrator of a hosted server, such as a virtual machine instance, may submit a rule to a rule-based DNS resolution system for generating DNS records to assist in discover of the hosted server. The rule may include criteria specifying servers to which the rule applies, as well as criteria for generating a domain name to associate with the server within a DNS record. The rule-based DNS resolution system can integrate with a hosting system providing the hosted server to obtain configuration information of the hosted server and generate DNS records in accordance with the rule. Rules may also be utilized to automate other aspects of the rule-based DNS resolution system, such as health checking and load balancing.

Abstract: There is disclosed a photography housing (10) for a portable electronic device (56) having an image sensor (58). The housing has first (12) and second (14) housing components defining at least a partial enclosure for receiving a portable electronic device, the first and second housing components being movably connected to one another, such that an internal dimension of the at least partial enclosure can be altered to releasably fit a dimension of the portable electronic device (56) inserted therein. The housing (10) comprises a user input device (22, 24, 26, 28) for controlling the operation of the image sensor (58) during use of the photography housing. The housing may provide a professional photography housing for a mobile telephone, e.g. providing ergonomic shutter control and photographic function selection via wireless communication with the mobile telephone.

Abstract: Systems and methods are described to enable integrating operation of a service record system with operation of an automatically scaled service hosting system. The service hosting system can maintain a set of servers to provide a network-accessible service, and the service record system can maintain records identifying the set of servers as endpoints for the service. The service hosting system can further modify the number of servers within the set based, for example, on demand. When the service hosting system intends to remove a server from the set, it may notify the service record system. The service record system, in turn, can determine whether any valid records are predicted to exist that identify the to-be-removed server as an endpoint for the service. If such records are predicted to exist, removal of the server can be delayed until those records expire, to prevent errors resulting from client reliance on those records.

Abstract: Systems and methods are described to enable integrating operation of a service record system with operation of a hosting system. The service hosting system can maintain a set of servers to provide a network-accessible service, and the service record system can maintain records identifying the set of servers as endpoints for the service. The service record system can periodically transmit health check data to servers within the set, to verify their health status. When the service record system determines that a server is unhealthy, it can notify the hosting system. If the hosting system removes the server from the pool, it can notify the service record system, so that the service record system can halt further health checking of the server.

Abstract: A service is described that makes it easy and cost-effective to configure network traffic flowing to multiple endpoints. Enterprises and developers can easily manage the way that end-users are routed to applications running in different geographic regions. Customers can route traffic based on multiple criteria in a customer policy. Customers can manage large-scale, multi-region applications, increase application availability, and minimize latency to end-users. The service can consider the state of end-users, such as their geography, their network, and their latency to different geographic regions. The service can also consider the state of the customer's applications, such as the load on the application, the application's health, the cost of using that application (e.g., resource costs), resource states (e.g., disk throughput), resource location, customer-provided endpoint cost parameters, etc.