Abstract: Disclosed herein are compounds useful for modulating the mu-opioid receptor (“MOR”) and/or delta-opioid receptor (“DOR”), and methods of using these compounds to treat diseases and conditions, such as pain. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.

Abstract: Described is a submersible floor or deck deployable in swimming pools and spas. The floor and seat panels are assembled and deployed in the basin or pool. The floor is mounted to a scaffolding and can be moved reversibly by a water pump or a hydraulic actuator between a lowered state substantially parallel to a floor of the pool and a raised state that is substantially flat and horizontal at a level substantially even with a top edge of the pool or spa. One version uses water flow from an existing or conventional water pump to circulate water that impinges on a paddlewheel that, in turn, drives one or more vertically mounted screws. The screws provide the vertical motive force to the floor.

Abstract: A vehicle mounted securing system is described. A rack is secured to the vehicle. Oblong slots formed in the rack provide a variety of locations at which to secure items to the racks. Brackets, strap mounts and the like are easily and removably attached to the rack by specially shaped disks or pucks which fit within the contours of a slot. Items may be secured by one or more bracket-puck combinations inside or outside of the vehicle.

Abstract: The present disclosure describes a method to treat conditions, including cancer, using compounds that can target resistant cancer cells. The compounds of the invention can decrease the rate of proliferation of drug-resistant cancer cells, such as glioma, lung cancer, and uterine sarcoma.

Abstract: A charging device for use with a power storage device includes a housing, a power conduit configured to deliver current to the power storage device, and a cable reel assembly coupled to the housing and to the power conduit. The cable reel assembly is configured to permit extension of a portion of said power conduit from said housing and to retract the portion of said power conduit into said housing.

Abstract: A vehicle mounted securing system is described. A rack is secured to the vehicle. Oblong slots formed in the rack provide a variety of locations at which to secure items to the racks. Brackets, strap mounts and the like are easily and removably attached to the rack by specially shaped disks or pucks which fit within the contours of a slot. Items may be secured by one or more bracket-puck combinations inside or outside of the vehicle.

Abstract: A deal management system is described which comprises a database storing first users' sell specifications and second users' buy specifications. Each sell specification comprises a locked portion and a non-locked portion of data. A matching module searches the non-locked portions using a searching specification, and a networking module sends an unlock request to a first user associated with a matching sell specification and provides the locked portion to a second user associated with the matched searching specification in response to receiving an unlock permission from the first user. A flow management module manages tasks associated with a specification acceptance process, and is responsive to a positive selection of a matched specification by a first user and a second user, and provides a graphical user interface for managing the tasks until the first and second users accept each other's buy and sell specifications and a deal regarding those specifications is completed.

Abstract: This invention is directed to a portable foaming apparatus for a handheld fire suppression system having a container holding a foaming agent, water and a pressurized gas, a foam generating assembly having a snorkel, a gas re-directional opening defined in the foam generating assembly allowing gas to enter the re-directional opening from the container; a nozzle in fluid communication with the gas re-directional opening and included in the foam generating assembly downstream of the snorkel so that gas entering the re-directional opening is inserted in the foam generating assembly downstream the snorkel; and, an outlet defined in the housing ejecting foam produced from the foaming agent and the gas when a foam nozzle attached to the foam generating assembly is actuated.

Abstract: A fire suppression apparatus and method of generating foam are provided in which a foam-forming liquid is introduced under high velocity and pressure into a mixing manifold through a plurality of jets, and a non-combustible gas is introduced under high velocity and pressure into the center of the mixing manifold, downstream of the jets and in the direction of flow of the foam-forming liquid. The foam generated in the mixing manifold is discharged through a hose and nozzle connected to the mixing manifold. The apparatus may be a self-contained unit, supported on a frame, with its own supply of foam-forming liquid and non-combustible gas.

Abstract: A charging device for use with a power storage device includes a housing, a power conduit configured to deliver current to the power storage device, and a cable reel assembly coupled to the housing and to the power conduit. The cable reel assembly is configured to permit extension of a portion of said power conduit from said housing and to retract the portion of said power conduit into said housing.

Abstract: This invention is directed to a foam generating apparatus having a mixing chamber housing inside a tank; a fluid injection head inside the mixing chamber housing for receiving the foaming agent traveling along an initial flow direction; a flow spoiler included in the fluid injection head for changing the initial flow direction of the foaming agent entering the fluid injection head; a first mixing chamber; a plurality of fluid ports included in the fluid injection head allowing foaming agent to exit the fluid injection head and enter the first mixing chamber thereby creating an intermediate foam in the first mixing chamber; a gas port allowing pressurized gas to mix with the intermediate foam generating output foam.

Abstract: A fire suppression apparatus and method of generating foam are provided in which a foam-forming liquid is introduced under high velocity and pressure into a mixing manifold through a plurality of jets, and a non-combustible gas is introduced under high velocity and pressure into the center of the mixing manifold, downstream of the jets and in the direction of flow of the foam-forming liquid. The foam generated in the mixing manifold is discharged through a hose and nozzle connected to the mixing manifold. The apparatus may be a self-contained unit, supported on a frame, with its own supply of foam-forming liquid and non-combustible gas.

Abstract: This invention is directed to a portable foaming apparatus for a handheld fire suppression system having a container holding a foaming agent, water and a pressurized gas, a foam generating assembly having a snorkel, a gas re-directional opening defined in the foam generating assembly allowing gas to enter the re-directional opening from the container; a nozzle in fluid communication with the gas re-directional opening and included in the foam generating assembly downstream of the snorkel so that gas entering the re-directional opening is inserted in the foam generating assembly downstream the snorkel; and, an outlet defined in the housing ejecting foam produced from the foaming agent and the gas when a foam nozzle attached to the foam generating assembly is actuated.