Abstract: Apparatuses for controlling gas flow are important components for delivering process gases for semiconductor fabrication. These apparatuses for controlling gas flow frequently rely on effectively sealed flow restrictors which can eliminate leakage of process gas around the flow restrictors. In one embodiment, a seal for a flow restrictor is disclosed, the seal comprising a plastic cylinder which is shrink fit onto a sealing portion of the flow restrictor. In another embodiment, a seal for a flow restrictor is disclosed, the seal having a first sealing ring with a flow aperture, a flow restrictor installed into the flow aperture.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: The following relates generally to systems and methods of trans-esophageal echocardiography (TEE) automation. Some aspects relate to a TEE probe with ultrasonic transducers on a distal end of the TEE probe. In some implementations, if a target is in a field of view (FOV) of the ultrasonic transducers, an electronic beam steering of the probe is adjusted; if the target is at an edge of the FOV, both the electronic beam steering and mechanical joints of the probe are adjusted; and if the target is not in the FOV, only the mechanical joints of the probe are adjusted.

Abstract: Various embodiments of the present disclosure encompass manipulative endoscopic guidance device employing an endoscopic viewing controller (20) for controlling a display of an endoscopic view (11) of an anatomical structure, and a manipulative guidance controller (30) for controlling a display of one or more guided manipulation anchors (50-52) within the display of the endoscopic view (11) of the anatomical structure. A guided manipulation anchor (50-52) is representative of a location marking and/or a motion directive of a guided manipulation of the anatomical structure (e.g., grasping, pulling, pushing, sliding, reorienting, tilting, removing, or repositioning of the anatomical structure).

Abstract: A medical instrument includes a first device (108) including shape-sensed flexible instrument, a second device (102) disposed over the first device and a third device (109) disposed over the first device and a portion of the second device. The second and third devices include a geometric relationship such that a position of the second device and the third device is determined from shape sensing information of the first device and the geometric relationship.

Abstract: A medical imaging element support unit is for use in fixing a medical imaging element (26) releasably against a region of skin of a subject. The includes a support body (14), having a base for engaging with skin of a subject in use and having a coupling means (22) for releasably coupling the medical imaging element (26) to the support body in use. A pneumatic positioning mechanism facilitates adjustment of a position of the medical imaging element relative to the support body, this being fluidly supplied by an air pump mechanism. The same air pump mechanism facilitates releasable fixation of the support body (14) to the skin, through creation of a configurable suction force at the skin engagement surface.

Abstract: A method and transmission system for amplifying and providing navigation signals. The system comprises a splitter circuit configured to receive a plurality of radio frequency (RF) signals oscillating at at least two different frequencies f1 and f2. The splitter circuit is further configured to split and forward the RF signals having the f1 frequency to a first bandpass filter and the RF signals having the f2 frequency to a second bandpass filter. The system further comprises a first tunable amplifier configured to receive the RF signals from the first bandpass filter. The system further comprises a second tunable amplifier configured to receive the RF signals from the second bandpass filter at substantially the same time as the first tunable amplifier's receipt of the RF signals from the first bandpass filter. The first tunable amplifier is further configured to amplify its RF signals across a first band centered around the frequency f1.

Abstract: A direct digital synthesis transmitter that uses a programmable digital circuit to generate a digital signal representing at least one radio frequency signal, the generated signal is filtered, amplified by an amplifier, and provided to a transmission antenna without upconversion. The transmitter generating the digital signal at a desired output frequency range such that a frequency upconverter is not needed to produce signals in the desired radio frequency range.

Abstract: A spacer supports first and second panes of an insulating unit wherein the spacer also compressively supports a third inner pane between the first and second panes. The spacer defines a channel that receives the outer perimeter edge of the third pane. The spacer on either side of a channel neck is deformed when the third pane is inserted into the channel. The resiliency of the spacer material causes the spacer material on both sides of the channel neck to compressively engage the third pane of glass. The spacer thus holds the inner spacer without the need for an adhesive disposed in the channel. This configuration closes the channel against the pane preventing the internal surface of the channel from being viewed which provides a desirable appearance to the inner portion of the insulating glass unit.

Abstract: Yeast strains and fermentation process for producing D-lactic acid and L-lactic acid are disclosed with higher titer, higher yield, shorter time, lower pH, and higher average specific productivity.

Abstract: The present disclosure provides a sensor cleaning system that cleans one or more sensors of an autonomous vehicle. Each sensor can have one or more corresponding sensor cleaning units that are configured to clean such sensor using a fluid (e.g., a gas or a liquid). Thus, the sensor cleaning system can include both a gas cleaning system and a liquid cleaning system. According to one aspect, the sensor cleaning system can provide individualized cleaning of the autonomous vehicle sensors. According to another aspect, a liquid cleaning system can be pressurized or otherwise powered by the gas cleaning system or other gas system.

Abstract: A system and method to identify a digital representation of a first musical composition including a set of musical blocks. A set of parameters associated with video content are identified. In accordance with one or more rules, one or more of the set of musical blocks of the first musical composition are modified based on the set of parameters to generate a derivative musical composition corresponding to the video content. An audio file including the derivative musical composition corresponding to the video content is generated.

Abstract: The present invention relates generally to the field of image processing. In particular, the present invention relates to a system and method for implementing a virtual fitting room that will provide an actual analysis of how a garment will fit a customer, and which will provide a realistic visual representation of the garment's fit on the customer.

Abstract: A robotic acoustic probe for application with an interventional device (60). The robotic acoustic probe employs an acoustic probe (20) including a imaging platform (21) having a device insertion port (22) defining a device insertion port entry (23) and device insertion port exit (24), and further including an acoustic transducer array (25) are disposed relative the device insertion port exit (24). The robotic acoustic probe further employs a robotic instrument guide (40) including a base (41) mounted to the imaging platform (21) relative to the device insertion port entry (23), and an end-effector (45) coupled to the base (41) and transitionable between a plurality of poses relative to a remote-center-of-motion (49). The end-effector (45) defines an interventional device axis (48) extending through the device insertion port (22), and the remote-center-of-motion (49) is located on the interventional device axis (48) adjacent the device insertion port exit (24).

Abstract: Apparatuses for controlling gas flow are important components for delivering process gases for semiconductor fabrication. These apparatuses for controlling gas flow frequently rely on flow restrictors which can provide a known flow impedance of the process gas. In one embodiment, a flow restrictor is disclosed, the flow restrictor constructed of a plurality of layers, one or more of the layers having a flow passage therein that extends from a first aperture at a first end of the flow restrictor to a second aperture at a second end of the flow restrictor.

Abstract: A system and method for determining the position of a non-shape-sensed guidewire (102) and for visualizing the guidewire. The system includes a shape-sensed catheter (104) having a lumen (103) that is configured to receive the non-shape-sensed guidewire. A measurement module (122) is configured to measure a distance that the non-shape-sensed guidewire moves. The measurement module may receive signals from a sensor (124) associated with a measurement assembly that is configured to receive at least a portion of the non-shape-sensed guidewire and/or the shape-sensed catheter. A location module (126) is configured to determine a position of the non-shape-sensed guidewire. The system is configured to generate a virtual image (101) of the guidewire, including a portion of the non-shape-sensed guidewire that does not extend along a shape-sensing optical fiber.

Abstract: The present invention discloses a genetically engineered Kluyveromyces sp. yeast strain that is capable of producing lactic acid from carbon source selected from glucose, fructose, sucrose or a mixture thereof wherein the genetically engineered yeast comprises at least one heterologous DNA cassette that confers production of a protein functioning as a fructose importer. The genetically engineered yeast strain according to this invention has an improvement of fructose utilization and use fructose as a faster rate than conventional strain, allowing for shorter fermentation times and improved economics.

Abstract: A protective assembly for use during laparoscopic surgery, the assembly comprising: a thin membrane formed from non-toxic material, the membrane being sufficiently thin and maneuverable to be passed through a cannula of a trocar; a flexible connector extending from the thin membrane; and an insertable shaft dimensioned to be passed through the cannula wherein a distal portion of the shaft is anchored to the flexible connector.

Abstract: A gas flow control system for delivering a plurality of gas flows. The gas flow control system has a gas flow path extending from a gas inlet to first and second gas outlets. First and second flow restrictors are operably coupled to the gas flow path. First and second valves are operably coupled to the gas flow path such that when both first and second valves are in a fully open state, flows of gas from the first and second gas outlets are split according to the impedances of the first and second flow restrictors.