Publication number: 20040176296
Abstract: Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
Type:
Application
Filed:
March 22, 2004
Publication date:
September 9, 2004
Applicant:
Millennium Pharmaceuticals, Inc.
Inventors:
Douglas A. Holtzman, Sean A. McCarthy, Kyle J. MacBeth, Samantha J. Busfield, Yang Pan, David White, Mehran M. Khodadoust, Wei Gu
Publication number: 20030082677
Abstract: Novel EDIRF, MTR-1, LSP-1, TAP-1, and PA-I polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length EDIRF, MTR-1, LSP-1, TAP-1, and PA-I proteins, the invention further provides isolated EDIRF, MTR-1, LSP-1, TAP-1, and PA-I fusion proteins, antigenic peptides and anti-EDIRF, MTR-1, LSP-1, TAP-1, and PA-I antibodies. The invention also provides EDIRF, MTR-1, LSP-1, TAP-1, and PA-I nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an EDIRF, MTR-1, LSP-1, TAP-1, and PA-I gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
Type:
Application
Filed:
January 30, 2001
Publication date:
May 1, 2003
Inventors:
Douglas A. Holtzman, Yang Pan, Sean A. McCarthy, David P. Gearing
Publication number: 20020072089
Abstract: Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti- ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
Type:
Application
Filed:
February 13, 2001
Publication date:
June 13, 2002
Inventors:
Douglas A. Holtzman, Sean A. McCarthy, Kyle J. MacBeth, Samantha J. Busfield, Yang Pan, David White, Mehran M. Khodadoust, Wei Gu