Abstract: An example medical device includes a vascular device, such as a catheter, and an anti-thrombogenic coating on a surface of the vascular device, such as a surface likely to contact blood. The anti-thrombogenic coating includes one or more peptides configured to interact with fibrinogen in the blood, such as a first type of peptides configured to bind to fibrinogen a second type of peptides configured to inhibit conversion of fibrinogen to fibrin. The anti-thrombogenic coating also includes a polymer, such as a hydrocolloid polymer, a tunable polyethylene glycol (PEG), or other controlled release polymer configured to control release of the one or more peptides and maintain a concentration of the peptides at the surface of the anti-thrombogenic coating above a minimum inhibitory concentration, thereby inhibiting thrombin formation on the intravascular medical device.

Abstract: An example catheter assembly includes a first catheter body portion defining a first lumen and a plurality of sidewall openings open to the lumen and configured to at least one of introduce fluid into a patient or remove fluid from the patient. The catheter assembly further includes a second catheter body portion defining a second lumen, a first cuff proximal to a distal end of the first catheter body portion, a second cuff distal to a proximal end of the second catheter body portion, and a connector configured to mechanically connect the first and second catheter body portions between the first and second cuffs and to fluidically connect the first and second lumens. A distance between the first and second cuffs is modifiable by at least modifying one of a length of the first catheter body portion or a length of the second catheter body portion.

Abstract: In some examples, a catheter assembly includes a catheter including an elongated catheter body defining a lumen, a first cuff and a second cuff. The first cuff includes a first cuff body comprising a material configured to promote epidermal tissue growth around or within the first cuff and an adhesive configured to adhere the first cuff body to an outer surface of the elongated catheter body at a first cuff position selectable by a user. The second cuff includes a second cuff body comprising the material configured to promote epidermal tissue growth around or within the second cuff body and an adhesive configured to adhere the second cuff body to the outer surface of the elongated catheter body at a second cuff position selectable by the user. A distance between the first and second cuff positions is customizable by the user based on a patient.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices and methods to guide delivery devices and instruments. Exemplary instrument guides, including for endoscopes as delivery devices for cryogen delivery catheters and to guide cryogen decompression tubes as instruments, and methods for use of such instrument guides for use in body lumens at treatment sites, are disclosed.

Abstract: A medical implant includes a primary tubular member having a first end and a second end and defining a primary longitudinal axis and a primary lumen. The primary tubular member is disposed in an arterial-venous connection. The medical implant also includes a baffle disposed transversely to the primary longitudinal axis within the primary lumen. The baffle defines at least one aperture therethrough.

Abstract: The present disclosure relates generally to the field of cryotherapy. In particular, the present disclosure relates to cryotherapy systems that ensure egress of cryogen gas delivered within a patient's body during cryotherapy procedures and, more particularly, sensors for use with cryotherapy systems that include delivery catheters wherein the systems ensure that egress of cryogen gas from the patient's body is possible whenever the catheter is operating.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: Provided is a manner of determining a performance indicator score for an entity. A method includes identifying a set of result indicators that contribute to a target result for a defined process. The set of result indicators include a first result indicator, a second result indicator, and a third result indicator. The method also includes determining a first score for the first result indicator, a second score for the second result indicator, and a third score for the third result indicator. Further, the method includes applying a first weight to the first score, a second weight to the second score, and a third weight to the third score. A master performance indicator score is determined based on a combination of the first score, the second score, and the third score as a function of the first weight, the second weight, and the third weight.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices and methods to guide delivery devices and instruments. Exemplary instrument guides, including for endoscopes as delivery devices for cryogen delivery catheters and to guide cryogen decompression tubes as instruments, and methods for use of such instrument guides for use in body lumens at treatment sites, are disclosed.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: The present disclosure relates generally to the field of cryotherapy. In particular, the present disclosure relates to cryotherapy systems that ensure egress of cryogen gas delivered within a patient's body during cryotherapy procedures and, more particularly, sensors for use with cryotherapy systems that include delivery catheters wherein the systems ensure that egress of cryogen gas from the patient's body is possible whenever the catheter is operating.

Abstract: The present disclosure relates generally to the field of cryotherapy. In particular, the present disclosure relates to catheter sleeves for cryotherapy systems that inhibit and remove build-up and backflow of undesired material in the working channel of endoscopes during cryotherapy treatments.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.

Abstract: The present invention provides methods for increasing cell culture performance through the use of chemically defined feed media (CDFM). In particular, the present invention provides methods for the use of surfactants as supplements to CDFM to allow for higher concentrations of media components and thereby result in increased cell culture performance.

Abstract: The present invention relates to the field of protein production and, in particular, to methods and compositions for modulating the glycosylation of recombinant proteins expressed in host cells using cell culture media supplemented with cobalt.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.