Abstract: A medical implant includes a primary tubular member having a first end and a second end and defining a primary longitudinal axis and a primary lumen. The primary tubular member is disposed in an arterial-venous connection. The medical implant also includes a baffle disposed transversely to the primary longitudinal axis within the primary lumen. The baffle defines at least one aperture therethrough.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: A performance indicator score can be determined for a software development process. A set of elements representing performance attributes of a software development process, such as quality and availability, can be determined. Scores for each element of the set of elements can be computed and aggregated into a single overall score. Further, an adjustment can be determined and applied to scores based on time or an expected event. The overall score can then be conveyed for display on a display device. Some thresholds can also be employed to evaluate the scores, including the overall score, and alerts can be triggered based on the thresholds.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: A medical implant includes a primary tubular member having a first end and a second end and defining a primary longitudinal axis and a primary lumen. The primary tubular member is disposed in an arterial-venous connection. The medical implant also includes a baffle disposed transversely to the primary longitudinal axis within the primary lumen. The baffle defines at least one aperture therethrough.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: Provided is a manner of determining a performance indicator score for an entity. A method includes identifying a set of result indicators that contribute to a target result for a defined process. The set of result indicators include a first result indicator, a second result indicator, and a third result indicator. The method also includes determining a first score for the first result indicator, a second score for the second result indicator, and a third score for the third result indicator. Further, the method includes applying a first weight to the first score, a second weight to the second score, and a third weight to the third score. A master performance indicator score is determined based on a combination of the first score, the second score, and the third score as a function of the first weight, the second weight, and the third weight.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.

Abstract: The present invention provides methods for increasing cell culture performance through the use of chemically defined feed media (CDFM). In particular, the present invention provides methods for the use of surfactants as supplements to CDFM to allow for higher concentrations of media components and thereby result in increased cell culture performance.

Abstract: The present invention relates to the field of protein production and, in particular, to methods and compositions for modulating the glycosylation of recombinant proteins expressed in host cells using cell culture media supplemented with cobalt.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.

Abstract: In one aspect of the present disclosure, a catheter includes an elongate shaft, first and second tip segments, and a hydrogel. The elongate shaft has a proximal end and a distal end defining a longitudinal axis. Each of the first and second tip segments includes a proximal portion and a distal portion, the proximal portion of each of the first and second tip segments coupled to the distal end of the elongate shaft. The hydrogel is disposed along a movable portion of the first tip segment. The movable portion of the first tip segment is movable relative to the longitudinal axis under a force of volumetric expansion of the hydrogel.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: The present invention relates to methods of selecting and developing a chemically defined media (“CDM”) for use in the manufacture of biological products. In particular, the present invention is directed to screening methods to determine cell culture technique media supplement blends with enhanced performance characteristics. The present invention is also directed to identifying CDM supplement blends that demonstrate significant increases in harvest titer and/or viable cell density.