Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of recombinant proteins expressed in host cells.

Abstract: In one aspect of the present disclosure, a catheter includes an elongate shaft, first and second tip segments, and a hydrogel. The elongate shaft has a proximal end and a distal end defining a longitudinal axis. Each of the first and second tip segments includes a proximal portion and a distal portion, the proximal portion of each of the first and second tip segments coupled to the distal end of the elongate shaft. The hydrogel is disposed along a movable portion of the first tip segment. The movable portion of the first tip segment is movable relative to the longitudinal axis under a force of volumetric expansion of the hydrogel.

Abstract: A medical catheter includes an elongate member and an insert. The elongate member has proximal and distal end portions and defines a longitudinal axis through the proximal and distal end portions. The elongate member includes a wall at least partially defining a longitudinal lumen and defining a side opening extending radially from an outer surface of the wall to the longitudinal lumen. The insert is at least partially disposed within the side opening and at least partially defines an insert passage in fluid communication with the longitudinal lumen. The elongate member includes a first material defining the side opening and the insert includes a second material different from the first material.

Abstract: The present invention relates to methods of selecting and developing a chemically defined media (“CDM”) for use in the manufacture of biological products. In particular, the present invention is directed to screening methods to determine cell culture technique media supplement blends with enhanced performance characteristics. The present invention is also directed to identifying CDM supplement blends that demonstrate significant increases in harvest titer and/or viable cell density.

Abstract: The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.

Abstract: The present invention relates to methods of selecting and developing a chemically defined media (“CDM”) for use in the manufacture of biological products. In particular, the present invention is directed to screening methods to determine cell culture technique media supplement blends with enhanced performance characteristics. The present invention is also directed to identifying CDM supplement blends that demonstrate significant increases in harvest titer and/or viable cell density.

Abstract: An apparatus for cutting medical tubes includes a frame having first and second members. Each of the first and second members has a tube support mount to assist in supporting a medical tube. The first and second members are adapted for relative movement between a first position for facilitating positioning of the medical tube proximal the tube supporting mounts and a second position for capturing the medical tube within the tube supporting mounts. A cutting element is mounted to the frame. The cutting element is moveable through a cutting plane and independent of the relative movement of the first and second members to sever the medical tube captured within the tube support mounts when in the second position of the first and second members. A manual member may be operatively connected to the cutting element and actuable through manual manipulation of a health care professional to move the cutting element.

Abstract: The present invention is directed to ball joint assemblies, end link and motor vehicles including such items. Such ball joint assemblies may include a ball stud having a spherical surface to be received by a ball socket, a threaded portion having a specific thread diameter for being received by a corresponding fastener. The ball stud may further include a wrench flat having a deck height for receiving a tool to restrain the ball stud, correspondingly sized to the specific thread diameter.