Abstract: A computational evidence platform extracts clinical concepts from medical evidence sources and creates a knowledge graph of elemental factors, investigations and therapeutic interventions (drug and nondrug therapies) all linked to medical conditions. Condition-dependent properties are stored between medical condition nodes and these factor, investigation and therapeutic intervention nodes. The knowledge graph is queried using natural language from a user interface, API or AI agent with contextual patient data or without. A document indexer creates elemental nodes from a document and a document node and stores these in the knowledge graph. A patient state is determined by extracting factors, investigations and therapies from a patient chart. Next-best actions per condition are determined by identifying factors, investigations and therapies not yet performed. Next-best actions across conditions are determined by assuming that therapies not present are now present in a patient chart.

Abstract: A computational platform includes a clinical knowledge graph having medical condition nodes to which are linked factor nodes and investigation nodes. Medical guideline nodes linked to a medical condition represent a computational guideline. Observation nodes and laboratory test nodes within the guideline link to factor nodes or investigation nodes. Therapy ingredient nodes represent drugs with a guideline. A patient is diagnosed or treated by traversing the guideline nodes associated with a particular condition. Probabilities annotated upon edges facilitate predicting a future patient state. Use cases include queries from a clinician, an insurance claims database, or an LLM, generation of FHIR value sets, and generation of executable CQL for a medical guideline. The knowledge graph receives a medical query, executes it and outputs a result. A medical condition ontology with factors and investigations connects to an ontology representing a computational medical guideline.

Abstract: A computational platform includes a clinical knowledge graph having medical condition nodes to which are linked factor nodes and investigation nodes. Medical guideline nodes linked to a medical condition represent a computational guideline. Observation nodes and laboratory test nodes within the guideline link to factor nodes or investigation nodes. Therapy ingredient nodes represent drugs with a guideline. A patient is diagnosed or treated by traversing the guideline nodes associated with a particular condition. Probabilities annotated upon edges facilitate predicting a future patient state. Use cases include queries from a clinician, an insurance claims database, or an LLM, generation of FHIR value sets, and generation of executable CQL for a medical guideline. The knowledge graph receives a medical query, executes it and outputs a result. A medical condition ontology with factors and investigations connects to an ontology representing a computational medical guideline.

Abstract: A computational platform includes a clinical knowledge graph having medical condition nodes to which are linked factor nodes and investigation nodes. Medical guideline nodes linked to a medical condition represent a computational guideline. Observation nodes and laboratory test nodes within the guideline link to factor nodes or investigation nodes. Therapy ingredient nodes represent drugs with a guideline. A patient is diagnosed or treated by traversing the guideline nodes associated with a particular condition. Probabilities annotated upon edges facilitate predicting a future patient state. Use cases include queries from a clinician, an insurance claims database, or an LLM, generation of FHIR value sets, and generation of executable CQL for a medical guideline. The knowledge graph receives a medical query, executes it and outputs a result. A medical condition ontology with factors and investigations connects to an ontology representing a computational medical guideline.

Abstract: A cooling system, such as a cooling vest, includes a cooling panel having a cooling panel body having a front wall, a rear wall, and an interior space between the front wall and the rear wall. A cooling member is positionable within the interior space of the cooling panel body, such as by being removably insertable thereinto. The cooling panel includes a conduction surface adapted to directly or indirectly contact an individual, such as a wearer, wherein the conduction surface is cooled by the cooling member in the interior space. Optionally, a fan can blow air chilled by the cooling member towards the individual so the individual can also experience convection cooling.

Abstract: A computational platform includes a clinical knowledge graph having medical condition nodes to which are linked factor nodes and investigation nodes. Medical guideline nodes linked to a medical condition represent a computational guideline. Observation nodes and laboratory test nodes within the guideline link to factor nodes or investigation nodes. Therapy ingredient nodes represent drugs with a guideline. A patient is diagnosed or treated by traversing the guideline nodes associated with a particular condition. Probabilities annotated upon edges facilitate predicting a future patient state. Use cases include queries from a clinician, an insurance claims database, or an LLM, generation of FHIR value sets, and generation of executable CQL for a medical guideline. The knowledge graph receives a medical query, executes it and outputs a result. A medical condition ontology with factors and investigations connects to an ontology representing a computational medical guideline.

Abstract: A computational platform includes a clinical knowledge graph having medical condition nodes to which are linked factor nodes and investigation nodes. Medical guideline nodes linked to a medical condition represent a computational guideline. Observation nodes and laboratory test nodes within the guideline link to factor nodes or investigation nodes. Therapy ingredient nodes represent drugs with a guideline. A patient is diagnosed or treated by traversing the guideline nodes associated with a particular condition. Probabilities annotated upon edges facilitate predicting a future patient state. Use cases include queries from a clinician, an insurance claims database, or an LLM, generation of FHIR value sets, and generation of executable CQL for a medical guideline. The knowledge graph receives a medical query, executes it and outputs a result. A medical condition ontology with factors and investigations connects to an ontology representing a computational medical guideline.

Abstract: A spinal traction/decompression therapy treatment can be performed using a therapeutic spa bath. The therapeutic spa bath can comprise a bathtub body having a central reservoir which can be filled with water. The bathtub body can include a floor, a backrest, a headrest, an upstanding sidewall, and a pair of leg cover shelves extending over the floor. A plurality of water jet nozzles can be mounted to the backrest, the headrest, the floor, and the leg cover shelves and a water pump can be operably coupled to the water jet nozzles by one or more conduits. In operation, the water pump provides pressurized water to the water jet nozzles for generating massaging water jets within the reservoir which provide the spa bath user with a hydromassage and gently pull the spa bath user's torso and head in opposite directions for providing a gentle spinal traction/decompression therapy treatment.

Abstract: A cooling system, such as a cooling vest, includes a cooling panel having a cooling panel body having a front wall, a rear wall, and an interior space between the front wall and the rear wall. A cooling member is positionable within the interior space of the cooling panel body, such as by being removably insertable thereinto. The cooling panel includes a conduction surface adapted to directly or indirectly contact an individual, such as a wearer, wherein the conduction surface is cooled by the cooling member in the interior space. Optionally, a fan can blow air chilled by the cooling member towards the individual so the individual can also experience convection cooling.

Abstract: A portable air cooler is provided that includes an openable top that provides access to a chest interior. The chest body also has as air inlet in the chest body through which ambient air can flow into the chest interior, an air outlet in the chest body through which air from the chest interior can flow out of the chest interior, and a fan operable to cause ambient air to flow into the chest interior through the air inlet and to cause air from the chest interior to flow out the air outlet. A chilling member is positionable in the chest interior to define an airflow pathway from the air inlet to the air outlet, wherein when the fan is operated, air is caused to flow from the air inlet through the airflow pathway to the air outlet, and wherein the chilling member comprises a heat exchange facilitating structure that chills air flowing through the airflow pathway so that the air at the air outlet is a lower temperature than the ambient air.

Abstract: Assemblies, systems, and methods for inspecting vehicles are disclosed. An assembly can comprise one or more cameras, one or more light sources s, and a housing configured to attach to a railway. The one or more cameras can be configured to capture images in a generally vertical direction and can be located below a top surface of one or more ties of a railway when the inspection assembly is attached to the railway. The housing can comprise a base a base configured to at least partially support the one or more cameras and the one or more light sources and a shroud sloped downwardly in a direction extending away from the one or more cameras.

Abstract: Assemblies, systems, and methods for inspecting vehicles are disclosed. An assembly can comprise a first angled camera, a second angled camera, an upright camera, lights, and a housing configured to attach to a railway. The first angled camera can be oriented at least partially in a generally vertical direction and at least partially in a first horizontal direction, and directed to a first target region from a first viewpoint. The second angled camera can be oriented at least partially in the generally vertical direction and at least partially in a second horizontal direction, and directed to a second target region from a second viewpoint. The upright camera can be oriented substantially in a vertical direction, and configured to capture images of a third target region from a third viewpoint.

Abstract: Provided herein are polypeptides, compositions comprising the polypeptides and methods for genome editing and gene regulation (e.g., activation and/or repression) using the polypeptides or the compositions comprising the polypeptides, such as, DNA binding domains derived from the genus of Ralstonia. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a TALE protein, such as, a Xanthomonas TALE protein. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a DNA binding protein derived from bacteria of the genus Ralstonia.

Abstract: An inspection assembly can comprise a first camera, a second camera, one or more lights, and a housing. The first camera can be angled at least partially in a vertical direction and at least partially in a horizontal direction to thereby be configured to capture images of a target region in a three-dimensional space from a first viewpoint. The second camera can be positioned apart from the first camera, angled at least partially in the vertical direction and at least partially in the horizontal direction, and directed to the target region from a second viewpoint that is different from the first viewpoint. The housing can comprise a base and a shroud and can be configured to attach to one or more rail ties and to at least partially envelop the first camera and the second camera.

Abstract: Assemblies, systems, and methods for inspecting vehicles are disclosed. An assembly can comprise a first angled camera, a second angled camera, an upright camera, lights, and a housing configured to attach to a railway between opposing rails. The first angled camera can be oriented at least partially in a vertical direction and at least partially in a first horizontal direction, and directed to a first target region from a first viewpoint. The second angled camera can be oriented at least partially in the vertical direction and at least partially in a second horizontal direction that is substantially opposite the first horizontal direction, and directed to a second target region from a second viewpoint. The upright camera can be oriented substantially in a vertical direction, and configured to capture images of a third target region from a third viewpoint.

Abstract: An inspection assembly can comprise a first camera, a second camera, one or more lights, and a housing. The first camera can be angled at least partially in a vertical direction and at least partially in a horizontal direction to thereby be configured to capture images of a target region in a three-dimensional space from a first viewpoint. The second camera can be positioned apart from the first camera, angled at least partially in the vertical direction and at least partially in the horizontal direction, and directed to the target region from a second viewpoint that is different from the first viewpoint. The housing can comprise a base and a shroud and can be configured to attach to one or more rail ties and to at least partially envelop the first camera and the second camera.

Abstract: Provided herein are polypeptides, compositions comprising the polypeptides and methods for genome editing and gene regulation (e.g., activation and/or repression) using the polypeptides or the compositions comprising the polypeptides, such as, DNA binding domains derived from the genus of Ralstonia. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a TALE protein, such as, a Xanthomonas TALE protein. Also disclosed are DNA binding proteins that include a fragment of N-cap sequence of a DNA binding protein derived from bacteria of the genus Ralstonia.

Abstract: An inspection assembly can comprise a first camera, a second camera, one or more lights, and a housing. The first camera can be angled at least partially in a vertical direction and at least partially in a horizontal direction to thereby be configured to capture images of a target region in a three-dimensional space from a first viewpoint. The second camera can be positioned apart from the first camera, angled at least partially in the vertical direction and at least partially in the horizontal direction, and directed to the target region from a second viewpoint that is different from the first viewpoint. The housing can comprise a base and a shroud and can be configured to attach to one or more rail ties and to at least partially envelop the first camera and the second camera.

Abstract: Assemblies, systems, and methods for inspecting vehicles are disclosed. An assembly can comprise a first angled camera, a second angled camera, an upright camera, lights, and a housing configured to attach to a railway between opposing rails. The first angled camera can be oriented at least partially in a vertical direction and at least partially in a first horizontal direction, and directed to a first target region from a first viewpoint. The second angled camera can be oriented at least partially in the vertical direction and at least partially in a second horizontal direction that is substantially opposite the first horizontal direction, and directed to a second target region from a second viewpoint. The upright camera can be oriented substantially in a vertical direction, and configured to capture images of a third target region from a third viewpoint.

Abstract: Railcar inspection systems, methods, and apparatuses are disclosed, including a railcar inspection portal. The railcar inspection portal includes a physical structure positioned around a railroad track, and through which a railcar can travel. The railcar inspection portal can include wheel detection sensors along the railroad track for detecting the presence of a railcar passing over the sensors. The sensors can transmit signals, corresponding to railcars passing over the sensors, to computing devices for determining railcar speeds. The railcar inspection portal can include imaging devices configured to capture images and readings of railcars passing through the inspection portal. Based on a determined speed corresponding to a passing railcar, the computing devices can control the imaging devices to capture specific areas or components of the passing railcar, or individual cars thereon.