Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises an actuator and a fluid chamber having a restricted outlet. The actuator is adapted to urge fluid from the fluid chamber through the restricted outlet. The feedback mechanism also has an indicator that is adapted to provide feedback to the user after a predetermined volume of fluid has passed from the fluid chamber through the restricted outlet during use of the injection device.

Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises an actuator and a fluid chamber having a restricted outlet. The actuator is adapted to urge fluid from the fluid chamber through the restricted outlet. The feedback mechanism also has an indicator that is adapted to provide feedback to the user after a predetermined volume of fluid has passed from the fluid chamber through the restricted outlet during use of the injection device.

Abstract: The present invention relates to dosage units of oral films for the administration of active pharmaceutical ingredients (API), such as analgesics, relaxants, anxiolytics, sedatives, hypnotics, narcotics, anesthetics and/or other API with peripheral and/or central nervous effects, in particular for use in the treatment of pain, metabolic disorders and diseases of the central nervous system (CNS). More particular the invention relates to dosage units of oral films comprising relaxants, anxiolytics, sedatives, hypnotics, narcotics, anesthetics and/or analgesics prone to misuse and abuse, such as overdosing. More particular, the invention relates to dosage units of oral films comprising propofol. In a further aspect, the invention relates to dosage units of oral films comprising propofol for use in the treatment of a subject suffering from migraine.

Abstract: A medicament delivery device comprising: a main body arranged to receive a medicament cartridge sealed with a penetrable barrier; a needle carrier carrying a needle; a cap removably coupled to the needle carrier, a pre-stressed spring connected to the needle carrier and to the main body, wherein the pre-stressed spring is held by an activation element coupled to the cap, wherein the activation element is arranged to release the spring when the cap is pulled in a distal direction from the device, thereby causing the needle carrier to move axially in a proximal direction.

Abstract: An assembly nest for transporting a tubular sub assembly of a drug delivery device on an automated production line, in which the tubular sub assembly includes a tubular body and a cap that is wider than the tubular body. The assembly nest includes a base against which a sub assembly of a drug delivery device is mountable to orientate said sub assembly in a predetermined position; and locking mechanism having a resilient member to urge the locking mechanism into one of: an unlocked position, in which a sub assembly of a drug delivery device can be mounted to the base; or a locked position, in which the locking mechanism engages a mounted sub assembly to retain it in its predetermined position on the base.

Abstract: A medicament delivery device comprising: a main body arranged to receive a medicament cartridge sealed with a penetrable barrier; a needle carrier carrying a needle; a cap removably coupled to the needle carrier, a pre-stressed spring connected to the needle carrier and to the main body, wherein the pre-stressed spring is held by an activation element coupled to the cap, wherein the activation element is arranged to release the spring when the cap is pulled in a distal direction from the device, thereby causing the needle carrier to move axially in a proximal direction.

Abstract: A medicament injection device comprising: a main body configured to receive a medicament cartridge, a needle sleeve axially movable with respect to the main body, a needle holder holding a needle, and a displacement element coupled to the needle holder and disengageably coupled to the needle sleeve; wherein, upon axial displacement of the needle sleeve by a predefined distance in a proximal direction, the needle carrier and needle are displaced axially in a proximal direction.

Abstract: A signal processor for providing one or more processed audio signals on the basis of one or more input audio signals is configured to estimate coefficients of an autoregressive reverberation model using the input audio signals and the delayed noise-reduced reverberant signals obtained using a noise reduction. The signal processor is configured to provide noise-reduced reverberant signals using the input audio signals and the estimated coefficients of the autoregressive reverberation model. The signal processor is configured to derive noise-reduced and reverberation-reduced output signals using the noise-reduced reverberant signals and the estimated coefficients of the autoregressive reverberation model. A method and a computer program include a similar functionality.

Abstract: A medicament injection device is provided. The device includes a main body configured to receive a medicament cartridge sealed with a penetrable holder. The device can further include a needle holder holding a needle, a needle sleeve arranged to be axially movable with respect to the main body, and a retainer coupled to the needle holder and to the needle sleeve. The retainer can be axially movable with respect to the main body along the main axis of the device. Upon displacement of the needle sleeve and the retainer by a predefined distance towards a proximal end of the main body, the needle holder and the needle can be displaced axially towards the proximal end of the main body and decouple from the retainer. The needle sleeve can be configured to disengage from the needle holder upon displacement of the needle sleeve.

Abstract: A signal processor for providing one or more processed audio signals on the basis of one or more input audio signals is configured to estimate coefficients of an autoregressive reverberation model using the input audio signals and the delayed noise-reduced reverberant signals obtained using a noise reduction. The signal processor is configured to provide noise-reduced reverberant signals using the input audio signals and the estimated coefficients of the autoregressive reverberation model. The signal processor is configured to derive noise-reduced and reverberation-reduced output signals using the noise-reduced reverberant signals and the estimated coefficients of the autoregressive reverberation model. A method and a computer program include a similar functionality.

Abstract: The disclosure relates to a drug delivery device for dispensing a liquid drug through a needle with a proximal and a distal needle tip, comprising a body, a needle holder holding the needle relative to the body, a cartridge holder holding a cartridge comprising the liquid drug sealed with a septum on a distal end and with a movable stopper on a proximal end, and a cap adapted to cover at least the distal needle tip of the needle, wherein the cartridge holder is movable relative to the body from a retracted position towards an advanced position, thereby piercing the proximal needle tipthrough the septum, characterized in that the cap is releasably engaged with the cartridge holder, wherein the cap is released from the cartridge holder in its advanced position.

Abstract: The present disclosure relates to an apparatus for the position determination of a cylinder piston located in a cylinder liner, said apparatus comprising: a port for coupling an electrical signal into or out of the interior of the cylinder liner, wherein a signal coupled into the interior of the cylinder liner interacts with the cylinder piston. The present disclosure is characterized by a unit for determining the position of the cylinder piston which is connected to the port and which is configured to determine the position of the cylinder piston in the cylinder liner with the aid of a vectorial measurement of a signal decoupled from the cylinder liner.

Abstract: An assembly nest for transporting a tubular sub assembly of a drug delivery device on an automated production line, in which the tubular sub assembly includes a tubular body and a cap that is wider than the tubular body. The assembly nest includes a base against which a sub assembly of a drug delivery device is mountable to orientate said sub assembly in a predetermined position; and locking mechanism having a resilient member to urge the locking mechanism into one of: an unlocked position, in which a sub assembly of a drug delivery device can be mounted to the base; or a locked position, in which the locking mechanism engages a mounted sub assembly to retain it in its predetermined position on the base.

Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises an actuator and a fluid chamber having a restricted outlet. The actuator is adapted to urge fluid from the fluid chamber through the restricted outlet. The feedback mechanism also has an indicator that is adapted to provide feedback to the user after a predetermined volume of fluid has passed from the fluid chamber through the restricted outlet during use of the injection device.

Abstract: A filter for generating an audio output signal includes a plurality of audio output signal samples based on two or more input microphone signals. The audio output signal and the two or more input microphone signals are represented in a time-frequency domain, wherein each of the plurality of audio output signal samples is assigned to a time-frequency bin of a plurality of time-frequency bins. The filter includes a weights generator being adapted to receive, for each of the plurality of time-frequency bins, direction-of-arrival information and weighting information. Moreover, the filter includes an output signal generator for generating the audio output signal.

Abstract: A medicament injection device comprising: a main body configured to receive a medicament cartridge, a needle sleeve axially movable with respect to the main body, a needle holder holding a needle, and a displacement element coupled to the needle holder and disengageably coupled to the needle sleeve; wherein, upon axial displacement of the needle sleeve by a predefined distance in a proximal direction, the needle carrier and needle are displaced axially in a proximal direction.

Abstract: A medicament delivery device comprising: a main body arranged to receive a medicament cartridge sealed with a penetrable barrier; a needle carrier carrying a needle; a cap removably coupled to the needle carrier, a pre-stressed spring connected to the needle carrier and to the main body, wherein the pre-stressed spring is held by an activation element coupled to the cap, wherein the activation element is arranged to release the spring when the cap is pulled in a distal direction from the device, thereby causing the needle carrier to move axially in a proximal direction.

Abstract: A medicament injection device comprising: a main body configured to receive a medicament cartridge sealed with a penetrable barrier, a needle holder holding a needle, a needle sleeve arranged around at least a portion of the needle holder and needle, and arranged to be axially movable with respect to the main body; and a retainer coupled to the needle holder and to the needle sleeve and axially movable with respect to the main body along the main axis of the device; wherein the retainer is coupled to the needle holder so that, upon displacement of the needle sleeve and the retainer by a predefined distance towards a proximal end of the main body, the needle holder and needle are displaced axially towards the proximal end of the main body and decouple from the retainer; and wherein the needle sleeve is configured to disengage from the needle holder upon axial displacement of the needle sleeve in the proximal direction beyond the predefined distance.

Abstract: The disclosure relates to a drug delivery device for dispensing a liquid drug through a needle with a proximal and a distal needle tip, comprising a body, a needle holder holding the needle relative to the body, a cartridge holder holding a cartridge comprising the liquid drug sealed with a septum on a distal end and with a movable stopper on a proximal end, and a cap adapted to cover at least the distal needle tip of the needle, wherein the cartridge holder is movable relative to the body from a retracted position towards an advanced position, thereby piercing the proximal needle tipthrough the septum, characterized in that the cap is releasably engaged with the cartridge holder, wherein the cap is released from the cartridge holder in its advanced position.

Abstract: The invention relates to a method for determining the piston position of a hydraulic or pneumatic piston cylinder unit, wherein the cylinder jacket and the piston form an electrical conducting path and the piston position is determined with the aid of the inductive and/or resistive properties of the conducting path that is formed. In addition, the invention relates to a piston cylinder unit having a measuring device for carrying out such a method.