Abstract: Provided herein are methods of treating myositis using an effective amount of a human neonatal Fc receptor (FcRn) antagonist. FcRn antagonists for use in the treatment of myositis and for use in the manufacture of a medicament for the treatment of myositis are also provided herein.

Abstract: Provided herein are methods, apparatuses, computer program products, and systems for a manufacturing data analysis system assistant. One method can include receiving, by an agent of a manufacturing data analysis system and from a user interface of the manufacturing data analysis system, an input related to manufacturing data; generating, by the agent, a prompt input based on context information related to the manufacturing data and a task identified for the input; providing, by the agent, the prompt input to a large language model (LLM); receiving, by the agent and from the LLM, a response that is based on the prompt input; and providing, by the agent, the response for display in the user interface.

Abstract: The present invention relates to methods of treating a disease or condition associated with the presence or formation of galectin-10 crystals, wherein the method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a Fab fragment that binds to galectin-10, wherein the composition is administered as an aerosol. Also included within the invention are pharmaceutical compositions comprising a Fab fragment that binds to galectin-10, and nebulizers comprising said pharmaceutical compositions. The pharmaceutical compositions may be useful for treating a disease or condition associated with the presence or formation of galectin-10 crystals, such as asthma or cystic fibrosis.

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6). In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments are particularly useful for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).

Abstract: A power semiconductor component for voltage limiting includes a rear-side base zone electrically contacted with a rear-side electrode and a front-side base zone electrically contacted with a front-side electrode. At least one switch-on structure is embedded at least into one of the rear-side base zone and the front-side base zone and is electrically contacted by the electrode contacting the embedding base zone. At least one triggering structure is provided as a breakdown structure of a first type, present between the front-side and rear-side electrodes. At least one further triggering structure is provided as a breakdown structure of a second type, present between the front-side and rear-side electrodes. The front-side and rear-side electrodes are each electrically conductively pressure-contacted by an electrically conductive contact plate at least one of which functions as a heat sink for dissipating heat generated in the semiconductor body.

Abstract: Disclosed is a battery cell including an electrode, a housing, a cell interior inside the housing, a temperature sensor, and a heat-conducting part which differs from the electrode, is entirely or partially disposed inside the housing of the battery cell, and is thermally connected to the temperature sensor.

Abstract: A semiconductor device includes a semiconductor body having opposite first and second surfaces, a gate region, and an active region arranged adjacent to the gate region in a horizontal direction. A first emitter, a first base, and a second base are arranged consecutively between the second and first surfaces in a vertical direction. A front-facing emitter is arranged in the active region and extends in the vertical direction from the first surface to the second base. Short-circuit regions extend from the first surface through the front-facing emitter to the second base. The active region has, in the horizontal direction, a first edge region adjacent to the gate region, a failure region adjacent to the first edge region, and a second edge region adjacent to the failure region. An average density of the short-circuit regions in the failure region is lower than in both edge regions.

Abstract: The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6). In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments are particularly useful for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).

Abstract: A method, in a server, for exchanging cryptographic keys for quantum-secure communication between the server and a client. The method includes: receiving a request message for a secure communication channel from a client, including at least one quantum-secure public ephemeral key and a first secret text; decapsulating the first secret text with a decapsulation function using a quantum-secure secret static key of the server, including generating a first secret; encapsulating the quantum-secure public ephemeral key with an encapsulation function including generating a second secret text and a second shared secret; encapsulating a quantum-secure public static key of the client using the encapsulation function, including generating a third secret text and a third shared secret; generating symmetric keys using at least the first, second, and third secrets; and sending a response message to the client, including the second and third secret texts.

Abstract: A power semiconductor component for voltage limiting includes a rear-side base zone electrically contacted with a rear-side electrode and a front-side base zone electrically contacted with a front-side electrode. At least one switch-on structure is embedded at least into one of the rear-side base zone and the front-side base zone and is electrically contacted by the electrode contacting the embedding base zone. At least one triggering structure is provided as a breakdown structure of a first type, present between the front-side and rear-side electrodes. At least one further triggering structure is provided as a breakdown structure of a second type, present between the front-side and rear-side electrodes. The front-side and rear-side electrodes are each electrically conductively pressure-contacted by an electrically conductive contact plate at least one of which functions as a heat sink for dissipating heat generated in the semiconductor body.

Abstract: A pod has an inner volume in which beverage ingredients are stored and in which a beverage is produced when water is introduced inside. The pod includes a body where water is introduced and a closing lid where the beverage is dispensed. The pod is made of a biodegradable material. The body has a three-dimensional shape. The body can be made of a multilayer material including a paper layer and a plastic sealing layer with a tensile value at break preferably between 2% and 20%. The body also can be made of a monolayer material consisting of plastic with a tensile value at break in the range between 2% and 1000%. The closing lid is flat and made of a material having a puncture resistance value between 3 N/15 mm and 10 N/15 mm for an elongation between 1.5 mm and 3 mm.

Abstract: A fluid channel for a power semiconductor module includes a die carrier configured to carry a plurality of semiconductor dies on a first side, a plurality of cooling elements arranged on a second side of the die carrier opposite the first side, and a channel wall arranged opposite the second side of the die carrier and forming a cavity. The cooling elements are arranged in the cavity. The cooling elements are attached to the die carrier at attachment points. A majority of the attachment points are positioned vertically in alignment with positions of the semiconductor dies.

Abstract: The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6). In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments are particularly useful for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).

Abstract: The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6). In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments are particularly useful for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).

Abstract: A fluid channel for a power semiconductor module includes a die carrier configured to carry a plurality of semiconductor dies on a first side, a plurality of cooling elements arranged on a second side of the die carrier opposite the first side, and a channel wall arranged opposite the second side of the die carrier and forming a cavity. The cooling elements are arranged in the cavity. The cooling elements are attached to the die carrier at attachment points. A majority of the attachment points are positioned vertically in alignment with positions of the semiconductor dies.

Abstract: A high-voltage battery for a motor vehicle has at least one battery cell for storing electrical energy and at least one temperature sensor, by which a temperature of the battery cell can be detected. The temperature sensor is arranged within the battery cell.

Abstract: The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6). In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments are particularly useful for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).

Abstract: Disclosed is a battery cell including an electrode, a housing, a cell interior inside the housing, a temperature sensor, and a heat-conducting part which differs from the electrode, is entirely or partially disposed inside the housing of the battery cell, and is thermally connected to the temperature sensor.