Abstract: A method for unloading a payload at a loading station includes selecting the payload to be unloaded from different payloads and registering a total target quantity of the selected payload to be unloaded at the loading station as a target quantity unit, a current total quantity of the selected payload that has already been unloaded at the loading station as an actual quantity unit, a number of already performed unloading procedures corresponding to a quantity of the selected payload that has already been unloaded at the loading station, or a difference between the target quantity unit and the actual quantity unit.

Abstract: A method for tipping out a cargo load from a reception unit includes providing the reception unit on a lifting device of a work machine, performing a tipping out process of a mass of cargo load from the reception unit, detecting a predetermined residual mass of the cargo load remaining in the reception unit, detecting a predetermined loading mass tipped out during the tipping step, and completing the tipping out process as a function of the predetermined residual mass or the predetermined loading mass.

Abstract: The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.

Abstract: An apparatus for forming glass tubes is provided. The apparatus includes a Danner-pipe, a heating device, and a heating chamber having the Danner-pipe and the heating device arranged therein. The Danner-pipe is inclined with respect to a horizontal plane by a Danner-angle. The heating device is inclined with respect to the horizontal plane by a heating-angle. The Danner-angle and/or the heating angle are in a range of 1° to 45°.

Abstract: An optical arrangement spectrally broadens laser pulses for nonlinear pulse compression. The optical arrangement has: a broadening section that is configured to guide a laser pulse repeatedly through at least one nonlinear broadening element. The nonlinear broadening element has a dispersion property that is selected such that the dispersion property compensates any self-focusing of the laser pulse in the nonlinear broadening element.

Abstract: The present invention relates to a process for the irradiation of a water-insoluble conjugate comprising a polymer Z to which a plurality of moieties -L2-L1-D is covalently conjugated or of a water-insoluble complex comprising a plurality of releasably and non-covalently bound drug molecules D-H or D-OH embedded in a polymer Z?, wherein the process comprises the steps of (a) providing said conjugate or complex; and (b) exposing the conjugate or complex to ionizing radiation; wherein each -L2- is independently a chemical bond or is a spacer moiety; each -L1- is independently a linker moiety covalently and reversibly attached to -D; and each -D is independently a drug moiety.

Abstract: The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.

Abstract: A system is described that receives a query model of a query that includes one or more query commands. The query model includes a command model that corresponds to at least query command of the one or more query commands. The system uses the command model to generate an interactive action model summary and causes a user interface to display the query and the interactive action model summary in a query actions panel. A modification to the query in the user interface causes an update to the query actions panel and a modification to the action model summary causes an update to the at least one query command of the query.

Abstract: A laser system includes a laser radiation source for providing pulsed laser radiation, and an optical system that includes a first polarization setting optical unit configured to set a circular polarization state of the pulsed laser radiation and a multipass cell having at least two mirrors. The pulsed laser radiation passes through the multipass cell with formation of a plurality of intermediate focus zones. The multipass cell is filled with a filling gas that has an optical nonlinearity and causes a spectral broadening of the pulsed laser radiation in the intermediate focus zones. A pressure of the filling gas is set in a pressure range so that there is an ionization behavior of the filling gas in a form of multiphoton ionization. Focus diameters of the intermediate focus zones are set such that the pulsed laser radiation passes through the multipass cell without ionization of the filling gas.

Abstract: An optical system for increasing contrast of pulsed laser radiation includes a first polarization setting optical unit for setting an elliptical polarization state of the pulsed laser radiation, and a multipass cell having at least two opposing mirrors. The pulsed laser radiation passes the multipass cell with formation of a plurality of intermediate focus zones. The multipass cell is filled with a gas having an optical nonlinearity that causes an intensity-dependent rotation of an alignment of the elliptical polarization state of the pulsed laser radiation, such that the multipass cell outputs beam portions having differently aligned elliptical polarization states on account of the intensity-dependent rotation. The optical system further includes an optical beam splitting system for splitting the beam portions having differently aligned elliptical polarization states.

Abstract: The present invention relates to an anti-CTLA4 conjugate or a pharmaceutically acceptable salt thereof, wherein said conjugate comprises a plurality of anti-CTLA4 moieties -D covalently conjugated via at least one moiety -L1-L2- to a polymeric moiety Z, wherein -L1- is covalently and reversibly conjugated to -D and -L2- is covalently conjugated to Z and wherein -L1- is a linker moiety and -L2- is a chemical bond or a spacer moiety; and related aspects.

Abstract: An apparatus for forming glass tubes is provided. The apparatus includes a Danner-pipe, a heating device, and a heating chamber having the Danner-pipe and the heating device arranged therein. The Danner-pipe is inclined with respect to a horizontal plane by a Danner-angle. The heating device is inclined with respect to the horizontal plane by a heating-angle. The Danner-angle and/or the heating angle are in a range of 1° to 45°.

Abstract: An optical arrangement spectrally broadens laser pulses for nonlinear pulse compression. The optical arrangement has: a broadening section that is configured to guide a laser pulse repeatedly through at least one nonlinear broadening element. The nonlinear broadening element has a dispersion property that is selected such that the dispersion property compensates any self-focusing of the laser pulse in the nonlinear broadening element.

Abstract: The present invention relates to a conjugate or its pharmaceutically acceptable salt, wherein said conjugate is water-in-soluble and comprises a carrier moiety Z to which one or more moieties -L2-L1-D are conjugated, wherein each -L2- is individually a chemical bond or a spacer moiety; each -L1- is individually a linker moiety to which -D is reversibly and covalently conjugated; and each -D is individually a pattern recognition receptor agonist. It further relates to pharmaceutical compositions comprising such conjugate and to their use in the treatment of cell-proliferation disorders; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA is administered by intra-tissue administration, and wherein the protein levels of at least one cytokine selected from the group consisting of IL-6, CCL2 and EL-10 in plasma has a more than 10-fold lower maximum protein level within 24 hours compared to an equivalent molar dose of the corresponding free PRRA upon intra/tissue administration; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) or its pharmaceutically acceptable salt or a pharmaceutical composition comprising such water-insoluble controlled-release PRRA or its pharmaceutical acceptable salt for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA, its pharmaceutically acceptable salt or the pharmaceutical composition is administered by intra-tissue administration, and wherein such intra-tissue administration results in local inflammation; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) or its pharmaceutically acceptable salt or a pharmaceutical composition comprising such water-insoluble controlled-release PRRA or its pharmaceutical acceptable salt for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA, its pharmaceutically acceptable salt or the pharmaceutical composition is administered by intra-tissue administration, and wherein at least 25% of the amount of PRRA remains local in such tissue 3 days after administration; and to related aspects.