Abstract: An optical system for increasing contrast of pulsed laser radiation includes a first polarization setting optical unit for setting an elliptical polarization state of the pulsed laser radiation, and a multipass cell having at least two opposing mirrors. The pulsed laser radiation passes the multipass cell with formation of a plurality of intermediate focus zones. The multipass cell is filled with a gas having an optical nonlinearity that causes an intensity-dependent rotation of an alignment of the elliptical polarization state of the pulsed laser radiation, such that the multipass cell outputs beam portions having differently aligned elliptical polarization states on account of the intensity-dependent rotation. The optical system further includes an optical beam splitting system for splitting the beam portions having differently aligned elliptical polarization states.

Abstract: The present invention relates to an anti-CTLA4 conjugate or a pharmaceutically acceptable salt thereof, wherein said conjugate comprises a plurality of anti-CTLA4 moieties -D covalently conjugated via at least one moiety -L1-L2- to a polymeric moiety Z, wherein -L1- is covalently and reversibly conjugated to -D and -L2- is covalently conjugated to Z and wherein -L1- is a linker moiety and -L2- is a chemical bond or a spacer moiety; and related aspects.

Abstract: An apparatus for forming glass tubes is provided. The apparatus includes a Danner-pipe, a heating device, and a heating chamber having the Danner-pipe and the heating device arranged therein. The Danner-pipe is inclined with respect to a horizontal plane by a Danner-angle. The heating device is inclined with respect to the horizontal plane by a heating-angle. The Danner-angle and/or the heating angle are in a range of 1° to 45°.

Abstract: An optical arrangement spectrally broadens laser pulses for nonlinear pulse compression. The optical arrangement has: a broadening section that is configured to guide a laser pulse repeatedly through at least one nonlinear broadening element. The nonlinear broadening element has a dispersion property that is selected such that the dispersion property compensates any self-focusing of the laser pulse in the nonlinear broadening element.

Abstract: Digital character animation automated generation techniques are described that are implemented by an animation generation system via a computing device. These techniques enable the animation generation system to generate an animation of a digital character automatically and without user intervention responsive to a user input of a target action such that the digital character is capable of performing a complex set of actions in a precise and realistic manner within an environment contained within digital content, e.g., an animation as part of a digital video.

Abstract: The present invention relates to a conjugate or its pharmaceutically acceptable salt, wherein said conjugate is water-in-soluble and comprises a carrier moiety Z to which one or more moieties -L2-L1-D are conjugated, wherein each -L2- is individually a chemical bond or a spacer moiety; each -L1- is individually a linker moiety to which -D is reversibly and covalently conjugated; and each -D is individually a pattern recognition receptor agonist. It further relates to pharmaceutical compositions comprising such conjugate and to their use in the treatment of cell-proliferation disorders; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA is administered by intra-tissue administration, and wherein the protein levels of at least one cytokine selected from the group consisting of IL-6, CCL2 and EL-10 in plasma has a more than 10-fold lower maximum protein level within 24 hours compared to an equivalent molar dose of the corresponding free PRRA upon intra/tissue administration; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) or its pharmaceutically acceptable salt or a pharmaceutical composition comprising such water-insoluble controlled-release PRRA or its pharmaceutical acceptable salt for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA, its pharmaceutically acceptable salt or the pharmaceutical composition is administered by intra-tissue administration, and wherein such intra-tissue administration results in local inflammation; and to related aspects.

Abstract: The present invention relates to a water-insoluble controlled-release pattern recognition receptor agonist (“PRRA”) or its pharmaceutically acceptable salt or a pharmaceutical composition comprising such water-insoluble controlled-release PRRA or its pharmaceutical acceptable salt for use in the treatment of a cell-proliferation disorder, wherein the water-insoluble controlled-release PRRA, its pharmaceutically acceptable salt or the pharmaceutical composition is administered by intra-tissue administration, and wherein at least 25% of the amount of PRRA remains local in such tissue 3 days after administration; and to related aspects.

Abstract: Digital character animation automated generation techniques are described that are implemented by an animation generation system via a computing device. These techniques enable the animation generation system to generate an animation of a digital character automatically and without user intervention responsive to a user input of a target action such that the digital character is capable of performing a complex set of actions in a precise and realistic manner within an environment contained within digital content, e.g., an animation as part of a digital video.

Abstract: The present invention relates to conjugates comprising crosslinked hyaluronic acid to which a plurality of drug moieties are covalently and reversibly conjugated, wherein the hyaluronic acid exhibits a certain degree of modification and comprises degradable crosslinked moieties. It also relates to their use as medicaments and their use in the diagnosis, prevention and treatment of diseases.

Abstract: The present invention relates to conjugates comprising backbone moieties that are crosslinked via particular crosslinker moieties to which a plurality of drug moieties are covalently and reversibly conjugated. It also relates to their use as medicaments and their use in the diagnosis, prevention and treatment of diseases.

Abstract: The present invention relates among other aspects to a conjugate or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said conjugate or its pharmaceutically acceptable salt for use in a method of preventing or treating an infection, wherein said conjugate is water-insoluble and comprises a polymeric moiety —Z to which a plurality of moieties -L2-X0D-L1-D are covalently conjugated, wherein each -D is independently an antibiotic moiety; each -L1- is independently a linker moiety to which -D is covalently and reversibly conjugated; each —X0D— is independently absent or a linkage and each -L2- is independently either a chemical bond or a spacer moiety.

Abstract: The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.

Abstract: A method for unloading a payload at a loading station includes selecting the payload to be unloaded from different payloads and registering a total target quantity of the selected payload to be unloaded at the loading station as a target quantity unit, a current total quantity of the selected payload that has already been unloaded at the loading station as an actual quantity unit, a number of already performed unloading procedures corresponding to a quantity of the selected payload that has already been unloaded at the loading station, or a difference between the target quantity unit and the actual quantity unit.

Abstract: A method for tipping out a cargo load from a reception unit includes providing the reception unit on a lifting device of a work machine, performing a tipping out process of a mass of cargo load from the reception unit, detecting a predetermined residual mass of the cargo load remaining in the reception unit, detecting a predetermined loading mass tipped out during the tipping step, and completing the tipping out process as a function of the predetermined residual mass or the predetermined loading mass.

Abstract: The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a VEGF neutralizing prodrug, which comprises a VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions.

Abstract: The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Abstract: The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.

Abstract: The present invention relates to compounds comprising a protecting group moiety-tag moiety conjugate, a method of purification and monoconjugates obtained from such method of purification.