Abstract: An apparatus for making a spunbond nonwoven laminate having a plurality of spunbond nonwoven layers has a row extending in a travel direction of two, three, or four spinning beams each emitting a multiplicity of multicomponent crimped continuous filaments with the filaments of each beam having a degree of crimp different from that of the filaments of each of the other beams. Respective extruders supply each beam with the components of the respective filaments and respective supply units feed each of the extruders with the respective components. The rate at which the components are supplied to the extruders is adjusted for varying the proportions of the components in each filament. A conveyor extends in the direction below the beams and receives the filaments as respective layers from the respective beams.

Abstract: Described herein are polyhydric alcohols having more than two hydroxyl groups in polyamide compositions including at least one polyamide to increase the weld seam strength after thermal aging of shaped articles produced from the polyamide composition by injection molding. During the injection molding, at least two flow fronts of the polyamide composition collide and form at least one weld seam.

Abstract: An endoscopic system (10) comprises an actuator (12) at a distal end (14) of the system (10), a manually operable actuating unit (18) at a proximal end (16) of the system (10), for actuating the actuator (12) and choosing an actuator force (F) by means of which the actuator (12) is intended to act on an object (20), the actuating unit (18) being displaceable between a start position and an end position, an actuator motor (24) designed to drive the actuator (12), and a control unit (30) designed to drive the actuator motor (24) initially on the basis of a position sensor (38) without exceeding a limit value (FTH) and then on the basis of a force sensor (40). Further, a method for driving an actuator (12) of an endoscopic system (10) is disclosed.

Abstract: The present invention concerns antigen binding proteins specifically binding melanoma associated antigen A (MAGE-A) protein-derived antigens. The invention in particular provides antigen binding proteins which specifically bind to the MAGE-A antigenic peptide comprising or consisting of SEQ ID NO: 1 in a complex with a major histocombatibility (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said MAGE-A peptide/MHC complex. The antigen binding proteins of the invention are of use for the diagnosis, treatment and prevention of MAGE-A expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: Disclosed is a polyamide composition including 30% to 99.9% by weight of a polyamide mixture as component A). Component A) includes aliphatic polyamide A1) and aliphatic copolyamide or terpolyamide A2). The weight ratio of A1) to A2) is 55:45 to 95:5. The polyamide composition also includes 0% to 60% by weight of glass fibers as component B), 0% to 2% by weight of nigrosin as component C), 0.1% to 10% by weight of at least one polyhydric alcohol including more than two hydroxyl groups and a number-average molecular weight (Mn) of less than 2000 as component D), 0% to 20% by weight of further additives as component E). The reported amounts sum to 100% by weight based on the total composition.

Abstract: The present invention concerns antigen binding proteins directed against PRAME protein-derived antigens. The invention in particular provides antigen binding proteins which are specific for the tumor expressed antigen PRAME, wherein the tumor antigen comprises or consists of SEQ ID NO: 50 and is in a complex with a major histocompatibility complex (MHC) protein. The antigen binding proteins of the invention contain, in particular, the complementary determining regions (CDRs) of novel engineered T cell receptors (TCRs) that specifically bind to said PRAME peptide. The antigen binding proteins of the invention are for use in the diagnosis, treatment and prevention of PRAME expressing cancerous diseases. Further provided are nucleic acids encoding the antigen binding proteins of the invention, vectors comprising said nucleic acids, recombinant cells expressing the antigen binding proteins and pharmaceutical compositions comprising the antigen binding proteins of the invention.

Abstract: The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: The invention relates to a medical instrument having an elongated shaft, a movable tool at a distal end of the shaft, a handle with a movable grip part at a proximal end of the shaft, and a force transmission element which can be moved in the longitudinal direction of the instrument and is operatively connected to the movable grip part and to the tool such that an actuation of the movable grip part is converted into a movement of the tool. The instrument has a spring assembly that is arranged on the handle and has at least one leg spring, which has at least one winding and two legs, and a pin, wherein the at least one winding extends about the pin. When the movable grip part is actuated, a force is applied to at least one of the legs of the leg spring, said force reducing the friction between the winding and the pin such that the leg spring can be rotated about the pin and the force transmission element and the tool can be moved.

Abstract: Methods for managing transmission resource conflicts, particularly for cellular networks utilised unlicensed resources. Mobile devices may be configured using higher layer signalling to respond to RTS signals if the transmission resources are available.

Abstract: A method of configuring a UE operating in a cellular communications system for discontinuous reception includes the steps of receiving or configuring a plurality of discontinuous reception configurations at the UE, selecting at least one of the discontinuous reception configurations for use by the UE, and operating the UE according to the at least one selected discontinuous reception configuration.

Abstract: A flexibly deformable chain that includes connectors for electrical contacting. Each of the connectors can include a first component in which electrically conductive contacts can be retained. The first component can be made from a fire-retardant plastic. Additionally, a second component can allow mechanical connection of each of the connectors in the flexibly deformable chain. The second component can have an ignition point which is lower than an ignition point of the first component and the second component can have an elasticity which is greater than an elasticity of the first component.

Abstract: A sequence of paging indication messages is transmitted, whereby each message indicates which UEs should decode subsequent signals. Each paging indication message may refer to a further paging indication message or to a paging message. The paging indication messages may be reference signal based or DCI based.

Abstract: For transmission of tracking reference signals in a cellular network a periodic set of transmission occasions is defined. A window is also defined in relation to at least one paging occasion, wherein the base station does not transmit tracking reference signals outside of the window. The base station also transmits an indication of active transmission occasions within the window and only transmits tracking reference signals in active transmission occasions.

Abstract: A connector for electrical contacting that includes a body configured to mechanically retain at least one electrically conductive contact, which is accessible on an exit side of the body for electrically contacting at least one other electrical contact. The body is constructed from at least two different components, with a first component of the at least two different components at least substantially forming the exit side and being made from a fire-retardant plastic, and a second component of the at least two different components having an ignition point which is lower than an ignition point of the first component of the at least two components, and the second component of the at least two different components having an elasticity which is greater than an elasticity of the first component of the at least two different components.

Abstract: A method of transmitting a wake-up signal from a base station to a user equipment (UE) in a cellular communications system is disclosed. The base station is configured to transmit a plurality of beams. The method includes transmitting a burst of wake up signals, and the burst of wake up signals includes at least one wake up signal transmitted on each beam.

Abstract: The invention relates to a medical instrument having an elongated shaft, a movable tool at a distal end of the shaft, a handle with a movable grip part at a proximal end of the shaft, and a force transmission element which can be moved in the longitudinal direction of the instrument and is operatively connected to the movable grip part and to the tool such that an actuation of the movable grip part is converted into a movement of the tool. The instrument has a spring assembly that is arranged on the handle and has at least one leg spring, which has at least one winding and two legs, and a pin, wherein the at least one winding extends about the pin. When the movable grip part is actuated, a force is applied to at least one of the legs of the leg spring, said force reducing the friction between the winding and the pin such that the leg spring can be rotated about the pin and the force transmission element and the tool can be moved.

Abstract: Disclosed herein is a thermoplastic molding composition, including: a) 30 to 99.85 wt % of at least one thermoplastic polyamide as component A; b) 0.1 to 10 wt % of at least one polyhydric alcohol having more than 6 hydroxyl groups, and having a number average molecular weight Mn of more than 2000 g/mol as component B; c) 0.05 to 3 wt % of at least one sterically hindered phenol antioxidant as component C; d) 0 to 3 wt % of at least one polycarboxylic compound having more than 3 carboxylic acid groups and/or carboxylate groups, and having a number average molecular weight Mn of more than 300 g/mol as component D; e) 0 to 50 wt % of at least one fibrous and/or particulate filler as component E; and f) 0 to 25 wt % of further additives as component F; where the total of wt % of components A to F is 100 wt %.

Abstract: Described herein is a thermoplastic molding composition, including 30 to 99.8 wt % of at least one thermoplastic polyamide as component A; 0.001 to 5 wt % of at least one polyethylenimine homo-or copolymer as component B; 0.1 to 2.0 wt % of at least one condensation product of secondary aryl amines and aliphatic aldehydes, aliphatic ketones, or mixtures thereof, or a combination of at least one secondary aryl amine and the at least one condensation product as component C; 0 to 3 wt % of at least one lubricant as component D; 0 to 50 wt % of at least one fibrous and/or particulate filler as component E; and 0 to 25 wt % of further additives as component F, where a total of wt % of components A to F is 100 wt %, which is free from copper.

Abstract: A dishwasher includes a memory unit for storing a number of washing programs, a control device configured to carry out a washing program from the number of washing programs; and a communication unit configured to retrieve a specific washing program from an external device in accordance with a status information relating to an external household appliance, and to store the retrieved specific washing program in the memory unit, said control device carrying out the stored specific washing program.

Abstract: Disclosed herein is a thermoplastic molding composition which includes A) from 10 to 99.9% by weight of a thermoplastic polyamide, B) from 0.1 to 20% by weight of at least one hyperbranched polyester having an acid number in the range of from 10 to 700 mg KOH/g and a hydroxyl number in the range of from 0 to 550 mg KOH/g, C) from 0 to 50% by weight of fibrous or particulate fillers, and D) from 0 to 45% by weight of further additives, where the total of the percentages by weight of components A) to D) is 100% by weight.